27 Results for "

CBR1

" in MedChemExpress (MCE) Product Catalog:
Products (27)

27 Results for "CBR1" in MCE Product Catalog:

  • Isoforms Recommended:
34
34 Publications Verification
Cat. No.: HY-N0148
CAS No.: 153-18-4
Synonyms: Rutoside; Quercetin 3-O-rutinoside
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress [1] .
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12
12 Cited Publications
Cat. No.: HY-13930
CAS No.: 22688-79-5
Purity:  99.96%
Synonyms: Quercetin 3-O-glucuronide; Quercetin 3-glucuronide
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor. Miquelianin is permeable to the blood-brain barrier [1] .
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4
4 Cited Publications
Cat. No.: HY-N2609
CAS No.: 2196-14-7
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production [1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM [1].
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1
1 Cited Publications
Cat. No.: HY-N0148R
CAS No.: 153-18-4
Synonyms: Rutoside (Standard); Quercetin 3-O-rutinoside (Standard)
Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress [1] .
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Cat. No.: HY-156694
CAS No.: 833481-77-9
Purity:  99.92%
Hydroxy-PP-Me is a selective CBR1 inhibitor with an IC50 of 759 nM. Hydroxy-PP-Me can inhibit serum starvation-induced apoptosis. Hydroxy-PP-Me can enhance the cytotoxic effects of Daunorubicin (HY-13062A) and As2O3 on tumor cells. Hydroxy-PP-Me can be used in the research of cancer such as leukemia [1] .
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Cat. No.: HY-N0566
CAS No.: 85999-40-2
Synonyms: Anemosapogenin
23-Hydroxybetulinic acid (Anemosapogenin) is an orally active triterpenoid with broad-spectrum anticancer activity. 23-Hydroxybetulinic acid reduces the levels of Bcl-2 and survivin, elevates the level of Bax, promotes the cleavage/activation of caspase-3 and caspase-9, and induces apoptosis via the endogenous mitochondrial pathway involving cytochrome C release and mitochondrial membrane potential disruption. 23-Hydroxybetulinic acid arrests the cell cycle at S and G1 phases, inhibits cancer cell proliferation, blocks the MAPK signaling pathway, regulates MMP2, and induces autophagic apoptosis by upregulating beclin-1. 23-Hydroxybetulinic acid inhibits the activity and efflux function of P-gp, increases the intracellular accumulation of chemotherapeutic drugs, and synergistically enhances cytotoxicity with Doxorubicin (HY-15142). 23-Hydroxybetulinic acid inhibits the phosphorylation and nuclear translocation of STAT6, blocks M2 macrophage polarization, and reduces M2 macrophage-mediated apoptosis resistance of colon cancer cells. 23-Hydroxybetulinic acid can be used in related studies on chronic myeloid leukemia, hepatocellular carcinoma, sarcoma 180, multidrug-resistant breast cancer, leukemia, Doxorubicin-induced cardiotoxicity, and colorectal cancer [1] .
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Cat. No.: HY-157445
CAS No.: 891101-69-2
Target:  

NADPH Oxidase

Research Areas:  

Metabolic Disease

CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC50 value of 0.034 μM [1].
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Cat. No.: HY-155587
CAS No.: 833481-60-0
Purity:  99.66%
Target:  

Carbonyl Reductase Src

Research Areas:  

Cancer

Hydroxy-PP is a potent carbonyl reductase 1 (CBR1) inhibitor with an IC50 value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC50 value of 5 nM [1].
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Cat. No.: HY-121710
CAS No.: 23869-24-1
Purity:  97.02%
Synonyms: 7-Monohydroxyethylrutoside
Target:  

Carbonyl Reductase

Research Areas:  

Cardiovascular Disease

MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner [1].
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Cat. No.: HY-RS18341
Research Areas:  

Others

Cbr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cbr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-157448
CAS No.: 3028977-01-4
Target:  

Apoptosis

Research Areas:  

Cancer

CBR1-IN-6 (compound 1a) is a CBR1 inhibitor with chemosensitizing and cardioprotective activities [1].
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Cat. No.: HY-157449
CAS No.: 1798284-62-4
Target:  

Others

Research Areas:  

Cancer

CBR1-IN-5 (compound 13o) is a potent inhibitor of CBR1 with an IC50 of 0.1 μM [1].
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Cat. No.: HY-RS02004
Research Areas:  

Others

CBR1 Human Pre-designed siRNA Set A contains three designed siRNAs for CBR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS24820
Research Areas:  

Others

Cbr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cbr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-157451
CAS No.: 1119826-35-5
Target:  

Carbonyl Reductase

Research Areas:  

Cancer

CBR1-IN-7 (Compound JV-2) is a human CBR1 inhibitor (IC50=8 μM). CBR1-IN-7 can be used in cancer research [1].
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Cat. No.: HY-157447
CAS No.: 1798284-64-6
Target:  

Carbonyl Reductase

Research Areas:  

Cancer

CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC50=0.09 μM). CBR1-IN-4 can be used in cancer research [1].
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Cat. No.: HY-W744549
CAS No.: 116-58-5
Synonyms: 20β-DHF
20β-Dihydrocortisol (20β-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583). 20β-Dihydrocortisol is a weak endogenous agonist of the glucocorticoid receptor (GR). 20β-Dihydrocortisol can be converted from Hydrocortisone via CBR1 catalysis, a process dependent on NADPH. 20β-Dihydrocortisol can be used for the study of obesity [1].
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Cat. No.: HY-157450
CAS No.: 1119826-36-6
Target:  

NADPH Oxidase

Research Areas:  

Cancer

YF-Mo1 (compound 9) is a CBR1 inhibitor with an IC50 value of 1.1 μM [1].
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Cat. No.: HY-N2609R
CAS No.: 2196-14-7
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production [1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM [1].
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Cat. No.: HY-157452
CAS No.: 1137720-39-8
Target:  

Carbonyl Reductase

Research Areas:  

Cancer

(8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC50 of 0.21 μM [1].
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