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Isoforms Recommended:	CBR1

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CBR1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amyloid-β (2) Androgen Receptor (1) Apoptosis (6) Autophagy (3) Bcl-2 Family (1) c-Myc (1) Carbonyl Reductase (5) Caspase (1) CCR (2) COX (2) Drug Metabolite (1) Endogenous Metabolite (4) ERK (1) Glucocorticoid Receptor (1) HIF/HIF Prolyl-Hydroxylase (1) MMP (1) mTOR (1) NADPH Oxidase (3) NF-κB (2) p38 MAPK (1) PDK-1 (1) PI3K (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Small Interfering RNA (siRNA) (3) Src (1) Survivin (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (1) Endocrinology (2) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0148

Rutin Maximum Cited Publications 30 Publications Verification Rutoside; Quercetin 3-O-rutinoside	Amyloid-β Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress ^[1] .

HY-13930

Miquelianin 10+ Cited Publications Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Endogenous Metabolite	Neurological Disease Cancer
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a *CBR1* inhibitor. Miquelianin is permeable to the blood-brain barrier ^[1] .

HY-N2609

7,4'-Dihydroxyflavone 4 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and *CBR1* inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production ^[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM ^[1].

HY-N0148R

Rutin (Standard) Rutoside (Standard); Quercetin 3-O-rutinoside (Standard)	Reference Standards Amyloid-β Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress ^[1] .

HY-156694

Hydroxy-PP-Me	Apoptosis NADPH Oxidase Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Hydroxy-PP-Me is a selective *CBR1* inhibitor with an IC₅₀ of 759 nM. Hydroxy-PP-Me can inhibit serum starvation-induced apoptosis. Hydroxy-PP-Me can enhance the cytotoxic effects of Daunorubicin (HY-13062A) and As₂O₃ on tumor cells. Hydroxy-PP-Me can be used in the research of cancer such as leukemia ^[1] .

HY-N0566

23-Hydroxybetulinic acid Anemosapogenin	Apoptosis Autophagy Bcl-2 Family Caspase Survivin p38 MAPK MMP	Cancer
23-Hydroxybetulinic acid (Anemosapogenin) is an orally active triterpenoid with broad-spectrum anticancer activity. 23-Hydroxybetulinic acid reduces the levels of Bcl-2 and survivin, elevates the level of Bax, promotes the cleavage/activation of caspase-3 and caspase-9, and induces apoptosis via the endogenous mitochondrial pathway involving cytochrome C release and mitochondrial membrane potential disruption. 23-Hydroxybetulinic acid arrests the cell cycle at S and G1 phases, inhibits cancer cell proliferation, blocks the MAPK signaling pathway, regulates MMP2, and induces autophagic apoptosis by upregulating beclin-1. 23-Hydroxybetulinic acid inhibits the activity and efflux function of P-gp, increases the intracellular accumulation of chemotherapeutic drugs, and synergistically enhances cytotoxicity with Doxorubicin (HY-15142). 23-Hydroxybetulinic acid inhibits the phosphorylation and nuclear translocation of STAT6, blocks M2 macrophage polarization, and reduces M2 macrophage-mediated apoptosis resistance of colon cancer cells. 23-Hydroxybetulinic acid can be used in related studies on chronic myeloid leukemia, hepatocellular carcinoma, sarcoma 180, multidrug-resistant breast cancer, leukemia, Doxorubicin-induced cardiotoxicity, and colorectal cancer ^[1] .

HY-157445

CBR1-IN-3	NADPH Oxidase	Metabolic Disease
CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC₅₀ value of 0.034 μM ^[1].

HY-155587

Hydroxy-PP	Carbonyl Reductase Src	Cancer
Hydroxy-PP is a potent carbonyl reductase 1 (CBR1) inhibitor with an IC₅₀ value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC₅₀ value of 5 nM ^[1].

HY-121710

MonoHER 7-Monohydroxyethylrutoside	Carbonyl Reductase	Cardiovascular Disease
MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner ^[1].

HY-RS18341

Cbr1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cbr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cbr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cbr1 Mouse Pre-designed siRNA Set A Cbr1 Mouse Pre-designed siRNA Set A

HY-157448

CBR1-IN-6	Apoptosis	Cancer
CBR1-IN-6 (compound 1a) is a *CBR1* inhibitor with chemosensitizing and cardioprotective activities ^[1].

HY-157449

CBR1-IN-5	Others	Cancer
CBR1-IN-5 (compound 13o) is a potent inhibitor of *CBR1* with an IC₅₀ of 0.1 μM ^[1].

HY-RS02004

CBR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CBR1 Human Pre-designed siRNA Set A contains three designed siRNAs for CBR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CBR1 Human Pre-designed siRNA Set A CBR1 Human Pre-designed siRNA Set A

HY-RS24820

Cbr1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cbr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cbr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cbr1 Rat Pre-designed siRNA Set A Cbr1 Rat Pre-designed siRNA Set A

HY-157451

CBR1-IN-7	Carbonyl Reductase	Cancer
CBR1-IN-7 (Compound JV-2) is a human *CBR1* inhibitor (IC₅₀=8 μM). CBR1-IN-7 can be used in cancer research ^[1].

HY-157447

CBR1-IN-4	Carbonyl Reductase	Cancer
CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC₅₀=0.09 μM). CBR1-IN-4 can be used in cancer research ^[1].

HY-W744549

20β-Dihydrocortisol 20β-DHF	Glucocorticoid Receptor Drug Metabolite	Metabolic Disease
20β-Dihydrocortisol (20β-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583). 20β-Dihydrocortisol is a weak endogenous agonist of the glucocorticoid receptor (GR). 20β-Dihydrocortisol can be converted from Hydrocortisone via CBR1 catalysis, a process dependent on NADPH. 20β-Dihydrocortisol can be used for the study of obesity ^[1].

HY-157450

YF-Mo1	NADPH Oxidase	Cancer
YF-Mo1 (compound 9) is a *CBR1* inhibitor with an IC₅₀ value of 1.1 μM ^[1].

HY-N2609R

7,4'-Dihydroxyflavone (Standard)	COX Reference Standards CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production ^[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM ^[1].

HY-157452

(8S)-Methyl zearalenone	Carbonyl Reductase	Cancer
(8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC₅₀ of 0.21 μM ^[1].

HY-13930R

Miquelianin (Standard) Quercetin 3-O-glucuronide (Standard); Quercetin 3-glucuronide (Standard)	Reference Standards Endogenous Metabolite	Cancer
Miquelianin (Standard) is the analytical standard of Miquelianin. This product is intended for research and analytical applications. Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.

HY-157444

5,3',4',3'',4'',5''-6-O-Ethyl-EGCG	HIF/HIF Prolyl-Hydroxylase	Cancer
5,3',4',3'',4'',5''-6-O-Ethyl-EGCG (Y6) is a potent adjuvant obtained by optimization of the structure of EGCG. 5,3',4',3'',4'',5''-6-O-Ethyl-EGCG (Y6) decreases the expression of *HIF-1α* and *CBR1* at both the mRNA and protein levels ^[1].

HY-181670

WH23	Androgen Receptor c-Myc Akt mTOR ERK PDK-1 PI3K Apoptosis	Metabolic Disease Cancer
WH23 is a dehydrogenase/reductase SDR family member 11 (DHRS11) inhibitor with IC₅₀ values of 0.037 μM. WH23 binds to DHRS11, forming a hydrogen bond with the enzyme’s His210 residue. WH23 suppresses androgen receptor mRNA and protein expression, reduces c-Myc expression, and inhibits cancer cell proliferation. WH23 inhibits PI3K/AKT signaling by reducing phosphorylation of *PDK1, AKT, mTOR, and ERK. WH23 enhances Capivasertib (HY-15431)-induced cytotoxicity and apoptosis*. WH23 can be used for the research of luminal androgen receptor-positive triple-negative breast cancer ^[1].

Rutin Maximum Cited Publications 30 Publications Verification Rutoside; Quercetin 3-O-rutinoside	Flavonols Classification of Application Fields Plants Flavonoids other families Leguminosae Sunscreen Phenols Polyphenols Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress ^[1] .

Miquelianin 10+ Cited Publications Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a *CBR1* inhibitor. Miquelianin is permeable to the blood-brain barrier ^[1] .

7,4'-Dihydroxyflavone 4 Publications Verification	Flavonoids Classification of Application Fields Flavones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Endocrinology Source Classification	COX CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and *CBR1* inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production ^[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM ^[1].

Rutin (Standard) Rutoside (Standard); Quercetin 3-O-rutinoside (Standard)	Flavonols Structural Classification Flavonoids other families Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	Reference Standards Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress ^[1] .

23-Hydroxybetulinic acid Anemosapogenin	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis Autophagy Bcl-2 Family Caspase Survivin p38 MAPK MMP
23-Hydroxybetulinic acid (Anemosapogenin) is an orally active triterpenoid with broad-spectrum anticancer activity. 23-Hydroxybetulinic acid reduces the levels of Bcl-2 and survivin, elevates the level of Bax, promotes the cleavage/activation of caspase-3 and caspase-9, and induces apoptosis via the endogenous mitochondrial pathway involving cytochrome C release and mitochondrial membrane potential disruption. 23-Hydroxybetulinic acid arrests the cell cycle at S and G1 phases, inhibits cancer cell proliferation, blocks the MAPK signaling pathway, regulates MMP2, and induces autophagic apoptosis by upregulating beclin-1. 23-Hydroxybetulinic acid inhibits the activity and efflux function of P-gp, increases the intracellular accumulation of chemotherapeutic drugs, and synergistically enhances cytotoxicity with Doxorubicin (HY-15142). 23-Hydroxybetulinic acid inhibits the phosphorylation and nuclear translocation of STAT6, blocks M2 macrophage polarization, and reduces M2 macrophage-mediated apoptosis resistance of colon cancer cells. 23-Hydroxybetulinic acid can be used in related studies on chronic myeloid leukemia, hepatocellular carcinoma, sarcoma 180, multidrug-resistant breast cancer, leukemia, Doxorubicin-induced cardiotoxicity, and colorectal cancer ^[1] .

20β-Dihydrocortisol 20β-DHF	Structural Classification Endogenous metabolite Steroids Source Classification	Glucocorticoid Receptor Drug Metabolite
20β-Dihydrocortisol (20β-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583). 20β-Dihydrocortisol is a weak endogenous agonist of the glucocorticoid receptor (GR). 20β-Dihydrocortisol can be converted from Hydrocortisone via CBR1 catalysis, a process dependent on NADPH. 20β-Dihydrocortisol can be used for the study of obesity ^[1].

7,4'-Dihydroxyflavone (Standard)	Structural Classification Flavonoids Flavones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	COX Reference Standards CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production ^[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM ^[1].

Miquelianin (Standard) Quercetin 3-O-glucuronide (Standard); Quercetin 3-glucuronide (Standard)	Flavonols Structural Classification Flavonoids Microorganisms other families Phenols Polyphenols Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Miquelianin (Standard) is the analytical standard of Miquelianin. This product is intended for research and analytical applications. Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72272

	CBR1 Protein, Human (P.pastoris, His) Carbonyl Reductase 1; SDR21C1	Human	P. pastoris
	CBR1 is an NADPH-dependent reductase with broad substrate specificity and plays a key role in the reduction of various carbonyl compounds, including quinones, prostaglandins, menadione, and xenobiotics. Crucially, CBR1 converts the anthracyclines doxorubicin and daunorubicin into their cardiotoxic forms doxorubicin and daunorubicin. CBR1 Protein, Human (P.pastoris, His) is the recombinant human-derived CBR1 protein, expressed by P. pastoris , with N-6*His labeled tag.

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Host:	Mouse (3)
Reactivity:	Human (3)
Application:	ICC/IF (3) WB (3)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

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HY-P85567

	CBR1 Antibody (YA5259) 15 hydroxyprostaglandin dehydrogenase [NADP ]; 15-hydroxyprostaglandin dehydrogenase [NADP ]; Carbonyl reductase [NADPH] 1; CBR 1; CBR1; CBR1_HUMAN; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9 ketoreductase; Prostaglandin 9-ketoreductase; Prostaglandin E; 2; 9 reductase; Prostaglandin-E; 2; 9-reductase; SDR21C1.	WB, ICC/IF	Human
	CBR1 Antibody (YA5259) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CBR1.

HY-P80590

	CBR1 Antibody (YA810) 15 hydroxyprostaglandin dehydrogenase [NADP ]; 15-hydroxyprostaglandin dehydrogenase [NADP ]; Carbonyl reductase [NADPH] 1; CBR 1; CBR1; CBR1_HUMAN; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9 ketoreduc	WB, ICC/IF	Human
	CBR1 Antibody (YA810) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CBR1.

HY-P80590A

	CBR1 Antibody (YA810)(PBS only) 15 hydroxyprostaglandin dehydrogenase [NADP ]; 15-hydroxyprostaglandin dehydrogenase [NADP ]; Carbonyl reductase [NADPH] 1; CBR 1; CBR1; CBR1_HUMAN; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9 ketoreduc	WB, ICC/IF	Human
	CBR1 Antibody (YA810) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CBR1.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cbr1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cbr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cbr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

CBR1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CBR1 Human Pre-designed siRNA Set A contains three designed siRNAs for CBR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cbr1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cbr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cbr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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