20β-Dihydrocortisol (Synonyms: 20β-DHF)

Cat. No.: HY-W744549: Data Sheet
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20β-Dihydrocortisol (20β-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583). 20β-Dihydrocortisol is a weak endogenous agonist of the glucocorticoid receptor (GR). 20β-Dihydrocortisol can be converted from Hydrocortisone via CBR1 catalysis, a process dependent on NADPH. 20β-Dihydrocortisol can be used for the study of obesity.

For research use only. We do not sell to patients.

20β-Dihydrocortisol Chemical Structure

CAS No. : 116-58-5

Size	Stock	Quantity
5 mg	Get quote 3 - 4 Weeks 6 - 7 Weeks 7 - 8 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 3 - 4 Weeks 6 - 7 Weeks 7 - 8 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
25 mg	Get quote 3 - 4 Weeks 6 - 7 Weeks 7 - 8 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of 20β-Dihydrocortisol:

20α-Dihydrocortisol In-stock

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Description

In Vivo

Pharmacological inhibition of CBR1 in diet-induced obesity in mice results in more marked glucose intolerance with evidence for enhanced hepatic GR signaling. These findings suggest that CBR1 generating 20β-dihydrocortisol is a novel pathway modulating GR activation and providing enzymatic protection against excessive GR activation in obesity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

364.48

Formula

C₂₁H₃₂O₅

CAS No.

116-58-5

Appearance

Solid

Color

White to off-white

SMILES

O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@@]4([C@H](O)CO)O)=C1

Structure Classification

Steroids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Data Sheet (271 KB) SDS (254 KB) Handling Instructions (2659 KB)

References

[1]. Morgan RA, et al. Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity. Sci Rep. 2017 Sep 6;7(1):10633. [Content Brief]

20β-Dihydrocortisol Related Classifications

Metabolic Disease

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

20β-Dihydrocortisol116-58-520β-DHFGlucocorticoid ReceptorDrug MetaboliteMetabolite of Hydrocortisoneglucocorticoid receptorNADPHCBR1obesityInhibitorinhibitorinhibit

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