Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
COMT-IN-3
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "COMT-IN-3" in MCE Product Catalog:
Cat. No.: HY-W761397
CAS No.: 117568-28-2
Target:
Research Areas:
COMT-IN-3 is a competitive inhibitor of soluble catechol-O-methyltransferase (S-COMT). COMT-IN-3 coordinates with the Mg 2+ ion at the COMT active site via its catechol hydroxyl group, and its nitro group, as a strong electron-withdrawing substituent, further enhances the binding affinity. COMT-IN-3 interacts with the hydrophobic residues Trp38, Met40, and Trp143 at the back of the active site via its neutral nitrile tail, thereby competitively inhibiting COMT activity. COMT-IN-3 can be used in research related to Parkinson's disease .
Cat. No.: HY-113468AR
CAS No.: 300-48-1
Synonyms: 3-Methoxy-L-tyrosINe (Standard); 3-O-Methyl-L-DOPA (Standard)
Cat. No.: HY-W401531S
CAS No.: 1259947-39-1
Cat. No.: HY-W401531S1
CAS No.: 2714485-35-3
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
