2714485-35-3
Chemical Structure
(R)-3-O-Methyldopa-d3 hydrochloride
- CAS No.: 2714485-35-3
- Formula:C10H11D3ClNO4
- Molecular Weight:250.69
IUPAC Name: (R)-2-amino-3-(4-hydroxy-3-(methoxy-d3)phenyl)propanoic acid hydrochloride
InChIKey: UNETXNZYVGKTSS-LZMDQPJSSA-N
SMILES: OC([C@H](N)CC1=CC(OC([2H])([2H])[2H])=C(C=C1)O)=O.Cl
Biological Activity: (R)-3-O-Methyldopa-d3 (hydrochloride) is a deuterium labeled (R)-3-O-Methyldopa, and (R)-3-O-Methyldopa is an R-enantiomer of 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of L-DOPA and dopamine[1][2].
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(R)-3-O-Methyldopa-d3 hydrochloride | (R)-3-O-Methyldopa-d3 (hydrochloride) is a deuterium labeled (R)-3-O-Methyldopa, and (R)-3-O-Methyldopa is an R-enantiomer of 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of L-DOPA and dopamine. | |||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Asanuma M, Miyazaki I. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016 Jul 25;17(1):52. [Content Brief]
Keywords
