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Results for "

CRBN ligand 12

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-148290
    KTX-951

    		PROTACs IRAK Cancer
    KTX-951 is an orally active IRAK4 and IMiD (Ikaros/Aiolos) substrates PROTAC degrader (Kd = 3.5 nM). KTX-951 has DC50s of 13 nM, 14 nM and 13 nM for IRAK4, Ikaros and Aiolos, respectively. KTX-951 has IC50 of 35 nM for OCl-Ly10 CTG. KTX-951 has antitumor activity.(Pink: IRAK4 ligand-12 (HY-48932); Black: Linker (HY-W382009); Blue: CRBN Ligand Pomalidomide (HY-10984)) .
    KTX-951
  • HY-170058
    CRBN ligand-12

    		Ligands for E3 Ligase E1/E2/E3 Enzyme Cancer
    CRBN ligand-12 (Compound 9) is a CRBN-type E3 ubiquitin ligase ligand. CRBN ligand-12 can be used to prepare PROTACs .
    CRBN ligand-12
  • HY-182085
    E3 Ligase Ligand-linker Conjugate 227

    		E3 Ligase Ligand-Linker Conjugates Cancer
    E3 Ligase Ligand-Linker Conjugate 227 is an E3 ligase ligand-linker conjugate containing CRBN ligand-1 (HY-150799) and a linker (HY-W262798). E3 Ligase Ligand-linker Conjugate 227 can be linked to the target protein ligand BRD9 ligand-12 (HY-182084) to form a PROTAC molecule, XYD270 (HY-182082) .
    E3 Ligase Ligand-linker Conjugate 227

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