1057 Results for "

Ca(2+)

" in MedChemExpress (MCE) Product Catalog:
Products (1057)

1057 Results for "Ca(2+)" in MCE Product Catalog:

167
MitoTEMPO hydrate
MitoTEMPO hydrate
0 Images
167 Publications Verification
Art. -Nr.: HY-125944
CAS. Nr.: 1569257-94-8
Reinheit:  98.03%
Target:  

Mitochondrial Metabolism PINK1/Parkin NOD-like Receptor (NLR) Autophagy Calcium Channel Apoptosis

Forschungsgebiete:  

Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology

MitoTEMPO hydrate is a mitochondria-targeted antioxidant . MitoTEMPO hydrate induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. MitoTEMPO hydrate regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. MitoTEMPO hydrate reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. MitoTEMPO hydrate can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke [2] .
167
Mito-TEMPO
Mito-TEMPO
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167 Publications Verification
Art. -Nr.: HY-112879
CAS. Nr.: 1334850-99-5
Reinheit:  99.19%
Target:  

Calcium Channel PINK1/Parkin Mitochondrial Metabolism Apoptosis Autophagy NOD-like Receptor (NLR)

Forschungsgebiete:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology

Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. Mito-TEMPO can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke [2] .
142
Thapsigargin
Thapsigargin
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142 Cited Publications
Art. -Nr.: HY-13433
CAS. Nr.: 67526-95-8
Reinheit:  99.87%
Category:  

Infection Terpenoids Diterpenoids Plants Umbelliferae Disease Research Fields Cancer Thapsia garganica L.

Target:  

Calcium Channel SARS-CoV Apoptosis

Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca 2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types [2] .
127
BAPTA-AM
BAPTA-AM
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127 Cited Publications
Art. -Nr.: HY-100545
CAS. Nr.: 126150-97-8
Reinheit:  99.23%
BAPTA-AM is a well-known membrane permeable Ca 2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively .
102
Yoda 1
Yoda 1
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102 Cited Publications
Art. -Nr.: HY-18723
CAS. Nr.: 448947-81-7
Target:  

Piezo Channel Akt ERK Potassium Channel

Forschungsgebiete:  

Cardiovascular Disease

Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation [2] .
72
2-Aminoethyl diphenylborinate
2-Aminoethyl diphenylborinate
0 Images
72 Cited Publications
Art. -Nr.: HY-W009724
CAS. Nr.: 524-95-8
Synonyms: 2-APB
Target:  

Calcium Channel TRP Channel CRAC Channel

Forschungsgebiete:  

Cardiovascular Disease Inflammation/Immunology

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca 2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue [2] .
68
Neomycin sulfate
Neomycin sulfate
0 Images
68 Cited Publications
Art. -Nr.: HY-B0470
CAS. Nr.: 1405-10-3
Category:  

Disease Research Antibacterial Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields

Target:  

Environmental Pollutants Antibiotic Phospholipase Bacterial

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca 2+ release, MgATP-dependent Ca 2+ uptake, and electrical excitation-evoked skeletal muscle Ca 2+ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer [2].
57
Fluo-4 AM
Fluo-4 AM
0 Images
57 Cited Publications
Art. -Nr.: HY-101896
CAS. Nr.: 273221-67-3
Fluo-4 AM is a cell-permeable Ca 2+ (calcium ion) indicator (Ex/Em = 485/526 nm) .
45
Dizocilpine
Dizocilpine
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45 Cited Publications
Art. -Nr.: HY-15084B
CAS. Nr.: 77086-21-6
Reinheit:  99.90%
Synonyms: MK-801
Target:  

iGluR

Forschungsgebiete:  

Neurological Disease

Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux [2].
40
Bicuculline methochloride
Bicuculline methochloride
0 Images
40 Cited Publications
Art. -Nr.: HY-137790
CAS. Nr.: 38641-83-7
Reinheit:  99.35%
Synonyms: (-)-Bicuculline methochloride
Target:  

GABA Receptor

Forschungsgebiete:  

Neurological Disease

Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC50 value of 3 μM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca 2+ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders [2].
38
GSK1016790A
GSK1016790A
0 Images
38 Cited Publications
Art. -Nr.: HY-19608
CAS. Nr.: 942206-85-1
Target:  

TRP Channel Calcium Channel

Forschungsgebiete:  

Cardiovascular Disease Metabolic Disease

GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca 2+ influx and elevate intracellular Ca 2+ in HEK cells [2].
38
Bicuculline
Bicuculline
0 Images
38 Cited Publications
Art. -Nr.: HY-N0219
CAS. Nr.: 485-49-4
Synonyms: (+)-Bicuculline
Category:  

Alkaloids Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae

Target:  

GABA Receptor

Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca 2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice [2] .
36
BAPTA
BAPTA
0 Images
36 Cited Publications
Art. -Nr.: HY-100168
CAS. Nr.: 85233-19-8
Reinheit:  98.10%
BAPTA is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators [2] .
36
BAPTA tetrasodium
BAPTA tetrasodium
0 Images
36 Cited Publications
Art. -Nr.: HY-100168A
CAS. Nr.: 126824-24-6
Reinheit:  99.70%
Target:  

Phospholipase

Forschungsgebiete:  

Others

BAPTA tetrasodium is a selective and cell-impermeant chelator for calcium. BAPTA tetrasodium has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators [2] .
36
BAPTA tetrapotassium
BAPTA tetrapotassium
0 Images
36 Cited Publications
Art. -Nr.: HY-100168B
CAS. Nr.: 73630-08-7
Reinheit:  99.45%
BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators [2] .
33
STO-609
STO-609
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33 Cited Publications
Art. -Nr.: HY-19805
CAS. Nr.: 52029-86-4
Target:  

CaMK AMPK Autophagy

Forschungsgebiete:  

Metabolic Disease

STO-609 is a selective and cell-permeable inhibitor of the Ca 2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.
30
NPS-2143
NPS-2143
0 Images
30 Cited Publications
Art. -Nr.: HY-10007
CAS. Nr.: 284035-33-2
Reinheit:  99.94%
Synonyms: SB-262470A
Target:  

CaSR

Forschungsgebiete:  

Metabolic Disease

NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca 2+ concentrations (IC50=43 nM) elicited by activating the Ca 2+ receptor in HEK 293 cells expressing the human Ca 2+ receptor [2].
30
NPS-2143 hydrochloride
NPS-2143 hydrochloride
0 Images
30 Cited Publications
Art. -Nr.: HY-10171
CAS. Nr.: 324523-20-8
Reinheit:  99.98%
Synonyms: SB-262470A hydrochloride
Target:  

CaSR

Forschungsgebiete:  

Metabolic Disease

NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca 2+ concentrations (IC50=43 nM) elicited by activating the Ca 2+ receptor in HEK 293 cells expressing the human Ca 2+ receptor [2].
27
Fasudil Hydrochloride
Fasudil Hydrochloride
0 Images
27 Cited Publications
Art. -Nr.: HY-10341
CAS. Nr.: 105628-07-7
Reinheit:  99.97%
Synonyms: HA-1077 Hydrochloride; AT-877 Hydrochloride
Target:  

ROCK Calcium Channel Autophagy PKA PKC HIV

Forschungsgebiete:  

Cancer

Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca 2+ channel antagonist and vasodilator [2] .
27
Fasudil
Fasudil
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27 Cited Publications
Art. -Nr.: HY-10341A
CAS. Nr.: 103745-39-7
Synonyms: HA-1077; AT877
Target:  

ROCK Calcium Channel Autophagy PKA PKC

Forschungsgebiete:  

Cancer

Fasudil (HA-1077; AT877) is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil is also a potent Ca 2+ channel antagonist and vasodilator [2] .
Assay Types