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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Calpain-1
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Calpain-1" in MCE Product Catalog:
7
7 Publications Verification
Cat. No.: HY-19749
CAS No.: 181765-30-0
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Research Areas:
PD 151746 is a selective calpain-1 inhibitor with an IC50 of 260 nM. PD 151746 binds μ-calpain Ca 2+-binding sites, and shows selectivity over cathepsin B, papain, trypsin, thermolysin, and basal calcineurin. PD 151746 reduces Oxidized low-density lipoprotein (oxLDL)-induced cytotoxicity, apoptotic DNA fragmentation, and blocks IL-1α maturation. PD 151746 can be used for the research of atherosclerosis and psoriasis [1] .
2
2 Cited Publications
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Calpain-2-IN-1 (Formula 1A) is a isoform-specific calpain-2 inhibitor with Kis of 181 nM and 7.8 nM for calpain-1, and calpain-2, respectively. Calpain-2-IN-1 can be used for the research of neurodegenerative diseases and other diseases of synaptic function [1].
1
1 Cited Publications
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NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC50 of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI) [1].
1
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Alicapistat (ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD) [1]. Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM .
1
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Dazcapistat (BLD-2660) is an orally active small-molecule inhibitor of calpain 1, 2, and 9 (calpain 1, 2, 9). Dazcapistat reduces the expression/production level of IL-6 in injured lung tissue and alleviates fibrosis . Dazcapistat exerts anti-fibrotic effects in various animal models of fibrosis in the skin, liver and lung . Dazcapistat can be used in research related to coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis [1] .
1
Calpain-1 (pig) (μ-Calpain) is an intracellular Ca 2+-regulated cysteine protease. Calpain-1 (pig) exhibits neuroprotective effect [1] .
1
1
1 Cited Publications
Cat. No.: HY-P72113
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CAPN1; Calpain-1 Catalytic Subunit; Calpain 1; Calpain-1 Large Subunit; MuCANP; Micromolar-Calpain; CANPL1; Calpain Mu-Type; MuCL; CANP 1; CANP; Cell Proliferation-Inducing Protein 30; Cell Proliferation-Inducing Gene 30 Protein; Calpain, Large Polypeptid
Species:
Human
Source:
E. coli
Cat. No.: HY-P10073
CAS No.: 636566-40-0
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Cat. No.: HY-115753
CAS No.: 1448429-06-8
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Calpain Inhibitor-1 (compound 36) is a potent and selective cysteine protease calpain 1 (Cal1) inhibitor (IC50=100 nM; Ki=2.89 μM) [1].
Cat. No.: HY-148535
CAS No.: 145731-49-3
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Calpain Inhibitor XI is a reversible covalent inhibitor of calpain-1. Calpain Inhibitor XI can be used for the research of neurodegenerative disorders [1].
Cat. No.: HY-P72114
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CAPN1; Calpain-1 Catalytic Subunit; Calpain 1; Calpain-1 Large Subunit; MuCANP; Micromolar-Calpain; CANPL1; Calpain Mu-Type; MuCL; CANP 1; CANP; Cell Proliferation-Inducing Protein 30; Cell Proliferation-Inducing Gene 30 Protein; Calpain, Large Polypeptid
Species:
Mouse
Source:
E. coli
Synonyms: (1S,2R)-ABT-957
Target:
Research Areas:
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD) [1]. (1S,2R)-Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM .
Cat. No.: HY-109001R
CAS No.: 1254698-46-8
Synonyms: ABT-957 (Standard)
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Research Areas:
Alicapistat (Standard) is the analytical standard of Alicapistat (HY-109001). This product is intended for research and analytical applications. Alicapistat (ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD) [1]. Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
