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Cdc42-binding kinase

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標的別:	Cdc42-binding kinase (3)
研究分野別:	Cancer (3)

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Targets Recommended: Cdc42-binding kinase

製品番号	製品名	Target	研究分野	構造式

HY-111424

BDP9066 2 Publications Verification	Cdc42-binding kinase	Cancer
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC₅₀ of 64 nM for MRCKβ in SCC12 cells, K_i values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

HY-111423

BDP8900	Cdc42-binding kinase	Cancer
BDP8900 is a potent and selective inhibitor of myotonic dystrophy-related Cdc42-binding kinases (MRCKα and MRCKβ). BDP8900 reduces substrate phosphorylation, leading to morphological changes, motility inhibition and invasiveness of cancer cells .

HY-111424A

(R)-BDP9066	Cdc42-binding kinase	Cancer
(R)-BDP9066 is an isomer of BDP9066 and has lower activity compared to BDP9066. BDP9066 is a potent inhibitor of myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK). (R)-BDP9066 is derived from patent WO2019034890A1 (E118) .

Species:	Human (4)
Tag:	His (1) Tag Free (1) Strep (1) GST (3)
Source:	sf9 insect cells (1) Sf9 insect cells (3)

製品番号	Compare	製品名	Species	Source	Image

HY-P702635

	MRCKβ Protein, Human (sf9, GST) Cdc42BPB; Cdc42 binding protein kinase beta (DMPK-like); MRCKB; KIAA1124; Cdc42-binding protein kinase beta; myotonic dystrophy protein kinase-like beta; Cdc42-binding protein kinase beta (DMPK-like); EC 2.7.11.1; DMPK-like beta; MRCK beta; Myotonic dystrophy kinase-related Cdc42-binding kinase beta; Serine/threonine-protein kinase MRCK beta	Human	Sf9 insect cells
	CDC42BPB protein is a key serine/threonine protein kinase downstream of CDC42 that controls cytoskeletal dynamics and cell migration. CDC42BPB phosphorylates PPP1R12C and MYL9/MLC2, regulates actin reorganization and shapes cell dynamics. MRCKβ Protein, Human (sf9, GST) is the recombinant human-derived MRCKβ, expressed by Sf9 insect cells, with GST labeled tag.

HY-P705758

	MRCKβ Protein, Human (Active, sf9, His-StrepII-GST) Cdc42BPB; Cdc42 binding protein kinase beta (DMPK-like); MRCKB; KIAA1124; Cdc42-binding protein kinase beta; myotonic dystrophy protein kinase-like beta; Cdc42-binding protein kinase beta (DMPK-like); EC 2.7.11.1; DMPK-like beta; MRCK beta; Myotonic dystrophy kinase-related Cdc42-binding kinase beta; Serine/threonine-protein kinase MRCK beta	Human	sf9 insect cells

HY-P701817

	MRCKα Protein, Human (Active, sf9, GST) Cdc42BPA; Serine/threonine-protein kinase MRCK alpha; Cdc42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related Cdc42-binding kinase alpha; MRCK alpha; Myotonic dystrophy protein kinase-like alpha	Human	Sf9 insect cells
	The MRCKα protein is a key serine/threonine protein kinase downstream of CDC42 that coordinates cytoskeletal dynamics and cell migration. MRCKα phosphorylates PPP1R12C and MYL9/MLC2, regulating actin reorganization. MRCKα Protein, Human (sf9, GST) is the recombinant human-derived MRCKα protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P702634

	MRCKG Protein, Human (Active, sf9) Cdc42BPG; Cdc42 binding protein kinase gamma (DMPK-like); serine/threonine-protein kinase MRCK gamma; DMPK2; HSMDPKIN; kappa 200; MRCKgamma; MRCK gamma; DMPK-like gamma; Cdc42-binding protein kinase gamma; myotonic dystrophy protein kinase-like alpha; myotonic dystrophy protein kinase-like gamma; myotonic dystrophy protein kinase like protein; myotonic dystrophy kinase-related Cdc42-binding kinase gamma; MRCKG; KAPPA-200	Human	Sf9 insect cells
	MRCKG Protein, Human (sf9) is the recombinant human-derived MRCKG, expressed by Sf9 insect cells , with tag Free labeled tag. ,

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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