66 Results for "

Cell-permeable peptide

" in MedChemExpress (MCE) Product Catalog:
Products (66)

66 Results for "Cell-permeable peptide" in MCE Product Catalog:

19
19 Publications Verification
Cat. No.: HY-12048
CAS No.: 3895-92-9
Purity:  99.11%
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
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14
14 Cited Publications
Cat. No.: HY-100529
CAS No.: 179528-45-1
Purity:  98.57%
Target:  

Proteasome

Research Areas:  

Cancer

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective .
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11
11 Cited Publications
Cat. No.: HY-P0069
CAS No.: 1445179-97-4
Synonyms: AM-111; XG-102
Target:  

JNK

Research Areas:  

Others

D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.
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7
7 Cited Publications
Cat. No.: HY-18962
CAS No.: 20324-87-2
Research Areas:  

Cancer

AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding .
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7
7 Cited Publications
Cat. No.: HY-18962A
CAS No.: 134-47-4
Research Areas:  

Cancer

AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding .
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5
5 Cited Publications
Cat. No.: HY-P3229
CAS No.: 1071173-56-2
Target:  

NF-κB

Research Areas:  

Cancer

SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research .
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2
2 Cited Publications
Cat. No.: HY-P5985
CAS No.: 593267-11-9
Target:  

ERK

Research Areas:  

Others

mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange .
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2
2 Cited Publications
Cat. No.: HY-P0069A
Target:  

JNK

Research Areas:  

Neurological Disease

L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.
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1
1 Cited Publications
Cat. No.: HY-P4157
CAS No.: 2460055-10-9
Target:  

MDM-2/p53 Apoptosis

Research Areas:  

Metabolic Disease

FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells .
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1
1 Cited Publications
Cat. No.: HY-P2272A
Target:  

Wnt β-catenin

Research Areas:  

Cancer

NLS-StAx-h TFA is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells .
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Cat. No.: HY-P10108
Synonyms: Hxk2VBD peptide, Cell-permeable
Target:  

Hexokinase

Research Areas:  

Neurological Disease

Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .
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Cat. No.: HY-P1111
CAS No.: 222018-18-0
Target:  

Src Interleukin Related

Research Areas:  

Inflammation/Immunology

Lyn peptide inhibitor (YGYRLRRKWEEKIPNP-NH2) is a potent, cell-permeable Lyn kinase inhibitor that inhibits Lyn-coupled signaling pathways associated with the IL-5 receptor while preserving the integrity of other signals. Lyn peptide inhibitor blocks the activation of Lyn and inhibits the binding of Lyn tyrosine kinase to the βc subunit of the IL-3/GM-CSF/IL-5 receptor. Lyn peptide inhibitor can be used in the research of eosinophilic diseases such as asthma and allergy .
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Cat. No.: HY-P5960
Synonyms: PTBP1 α3-helix derived peptide P6 TFA
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

PTBP1-RNA-binding inhibitor (PTBP1 α3-helix derived peptide) P6 TFA is a cell-permeable PTBP1 inhibitor. PTBP1-RNA-binding inhibitor P6 TFA binds to the α3 helix binding site of the PTBP1 RRM1 domain, and disrupts the synergistic RNA-binding effect of the RRM1 and RRM2 domains of PTBP1. PTBP1-RNA-binding inhibitor P6 (TFA) regulates the regulatory pattern of PTBP1-related alternative splicing events, and thus exhibits anticancer potential .
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Cat. No.: HY-P10114
CAS No.: 400628-16-2
Synonyms: PpYLKTK-mts; STAT3 PI
Target:  

STAT

Research Areas:  

Cancer

STAT3-IN-24, cell-permeable (PpYLKTK-mts) is a STAT3 peptide inhibitor. STAT3-IN-24, cell-permeable inhibits recruitment of STAT3 to Jak2 and phosphorylation of Y705, thus preventing the dimerization and the nuclear translocation of STAT3 .
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Cat. No.: HY-P3245A
Target:  

Apoptosis

Research Areas:  

Cancer

HXR9 hydrochloride is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 hydrochloride antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 hydrochloride selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .
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Cat. No.: HY-16129
CAS No.: 565434-85-7
CBP-501, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser 216-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC50 values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 is used for various types of cancer .
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Cat. No.: HY-146127
CAS No.: 3069455-54-2
Target:  

MEK

Research Areas:  

Cancer

Grb2 SH2 domain inhibitor 1 is an inhibitor of the Grb2 SH2 domain with an IC50 of 0.40 μM. Grb2 SH2 domain inhibitor 1 is also a cell-permeable cyclic peptide that can enter the cytosol of mammalian cells. Grb2 SH2 domain inhibitor 1 downregulates the expression level of p-MEK. Grb2 SH2 domain inhibitor 1 can be used in the research of breast cancer .
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Cat. No.: HY-P4083
Target:  

Fluorescent Dye

Research Areas:  

Others

(Arg)9,TAMRA-labeled is a TAMRA-labeled cell permeable peptide. (Arg)9 is a cell-permeable peptide used for drug delivery .
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Cat. No.: HY-P1190
CAS No.: 610273-01-3
Target:  

JNK Apoptosis

Research Areas:  

Inflammation/Immunology

c-JUN peptide is a cell-permeable c-JUN-JNK interaction inhibitor. c-JUN peptide inhibits serum-induced c-Jun phosphorylation. c-JUN peptide induces apoptosis .
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Cat. No.: HY-P5118A
Target:  

Peptides

Research Areas:  

Neurological Disease

Tat-peptide 190-208 TFA is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 190-208 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 190-208 TFA increases axon growth and increases the number of neurites per neuron. Tat-peptide 190-208 TFA likely exhibits an axon intrinsic mechanism. Tat-peptide 190-208 TFA can be used for ischemic protection during endovascular repair for intracranial aneurysms .
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