134-47-4
134-47-4
Chemical Structure
AMI-1 free acid
- CAS No.: 134-47-4
- Formula:C21H16N2O9S2
- Molecular Weight:504.49
IUPAC Name: 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid)
InChIKey: PCGISRHGYLRXSR-UHFFFAOYSA-N
SMILES: O=C(NC1=CC2=CC(S(=O)(O)=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)(O)=O)=CC(O)=C4C=C3
Biological Activity: AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AMI-1 free acid | 99.53% | AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding. | ||||||||||||||||||||
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AMI-1 free acid (Standard) | ≥98% | AMI-1 (free acid) (Standard) is the analytical standard of AMI-1 (free acid). This product is intended for research and analytical applications. AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding. | ||||||||||||||||||||
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References
