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By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Akt (2) Amyloid-β (1) Apoptosis (2) Biochemical Assay Reagents (1) Cannabinoid Receptor (2) Cholecystokinin Receptor (2) Endogenous Metabolite (4) Endothelin Receptor (1) GABA Receptor (2) GLP Receptor (1) Integrin (1) Isotope-Labeled Compounds (1) Melatonin Receptor (1) Myosin (1) Natriuretic Peptide Receptor (NPR) (1) Neurokinin Receptor (5) Neurotensin Receptor (2) NO Synthase (1) Phosphodiesterase (PDE) (1) PI3K (2) Prostaglandin Receptor (3) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (10) Endocrinology (1) Infection (2) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (16)

By Targets:

5-HT Receptor (1)

Adrenergic Receptor (1)

Akt (2)

Amyloid-β (1)

Apoptosis (2)

Biochemical Assay Reagents (1)

Cannabinoid Receptor (2)

Cholecystokinin Receptor (2)

Endogenous Metabolite (4)

Endothelin Receptor (1)

GABA Receptor (2)

GLP Receptor (1)

Integrin (1)

Isotope-Labeled Compounds (1)

Melatonin Receptor (1)

Myosin (1)

Natriuretic Peptide Receptor (NPR) (1)

Neurokinin Receptor (5)

Neurotensin Receptor (2)

NO Synthase (1)

Phosphodiesterase (PDE) (1)

PI3K (2)

Prostaglandin Receptor (3)

Reactive Oxygen Species (ROS) (1)

By Research Areas:

Cancer (2)

Cardiovascular Disease (10)

Endocrinology (1)

Infection (2)

Inflammation/Immunology (6)

Metabolic Disease (1)

Neurological Disease (16)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0093

Sincalide 4 Publications Verification Cholecystokinin octapeptide; CCK-8; SQ19844	Cholecystokinin Receptor Apoptosis PI3K Akt	Infection Cancer
Sincalide (Cholecystokinin octapeptide, CCK-8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK. Sincalide can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK .

HY-101388

AM404 2 Publications Verification	Cannabinoid Receptor	Neurological Disease
AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC₅₀ values in the low micromolar range . AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC₅₀ value of 7.4 (corresponding to an EC₅₀ of 0.04 μM). Neuroprotective Effect .

HY-P0093A

Sincalide ammonium 4 Publications Verification Cholecystokinin octapeptide ammonium; CCK-8 ammonium; SQ19844 ammonium	Cholecystokinin Receptor Apoptosis PI3K Akt	Infection Cancer
Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide ammonium can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK .

HY-114367

Delphinidin 3-rutinoside chloride 1 Publications Verification Delphinidin 3-O-rutinoside chloride	Endothelin Receptor NO Synthase Myosin GLP Receptor	Neurological Disease Metabolic Disease
Delphinidin 3-rutinoside chloride is an anthocyanin component. Delphinidin 3-rutinoside chloride is isolable from the fruits of blackcurrant Ribes nigrum L. Delphinidin 3-rutinoside chloride activates the ET_B receptor and stimulates the NO/cGMP pathway. Delphinidin 3-rutinoside chloride increases cyclic guanosine monophosphate production and reduces the phosphorylation level of Myosin regulatory light chain. Delphinidin 3-rutinoside chloride stimulates GLP-1 secretion. It significantly induces relaxation of bovine ciliary muscle strips contracted by ET-1 and inhibits ET-1-induced contraction of bovine ciliary muscle strips. Delphinidin 3-rutinoside chloride is applicable to research related to type 2 diabetes .

HY-119926

13-Hydroxylupanine Hydroxylupanine	Integrin	Cardiovascular Disease Neurological Disease
13-Hydroxylupanine (Hydroxylupanine) is the typical alkaloid profile of sweet lupins.13-Hydroxylupanine blocks ganglionic transmission, decreases cardiac contractility and contracts uterine smooth muscle .

HY-113459

Prostaglandin F1a	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Prostaglandin F1a is a compound that has the effect of contracting smooth muscle and lowering blood pressure .

HY-136500

Prostaglandin H2 PGH2	Endogenous Metabolite Amyloid-β	Neurological Disease Inflammation/Immunology
Prostaglandin H2 (PGH2) is an endothelium-derived contracting factor. Prostaglandin H2 can cause vasoconstriction. Prostaglandin H2 is the common precursor of all PGs and is produced by several cells that express cyclooxygen-ases. Prostaglandin H2 can activate PGD2 receptors CRTH2 and DP via interacting directly with the receptors and/or by giving rise to PGD2 after catalytic conversion by plasma proteins. Prostaglandin H2 can induce eosinophils migration and inhibit platelet aggregation. Prostaglandin H2 can accelerate the formation of dimers and higher oligomers of amyloid β_1-42. Prostaglandin H2 can be used for the researches of inflammation and neurological disease, such as Alzheimer disease .

HY-P1256C

JMV 449 acetate	Neurotensin Receptor	Neurological Disease
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC₅₀ of 0.15 nM for inhibition of ¹²⁵I-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-101222

SB-203186 hydrochloride	5-HT Receptor	Cardiovascular Disease Neurological Disease
SB-203186 hydrochloride is a potent, selective and competitive 5-HT₄ antagonist. SB-203186 hydrochloride antagonizes the 5-HT₄ receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pK_B values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively .

HY-P3895A

Substance P (3-11) acetate	Neurokinin Receptor	Neurological Disease
Substance P (3-11) acetate is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) acetate has contracting activities on guinea pig ileum. Substance P (3-11) acetate also promotes human monocyte chemotaxis .

HY-123801

MIDD0301 GL-II-93	GABA Receptor	Inflammation/Immunology
MIDD0301 (GL-II-93) is an orally available, active γ-aminobutyric acid type A receptor (GABA_AR) inhibitor and anti-asthmatic agent. MIDD0301 exhibits biological and immunotoxicological safety in mice and does not affect the number of circulating lymphocytes, monocytes, and granulocytes. MIDD0301 has no significant adverse immune response at repeated doses, which is better than Prednisone (HY-B0214). MIDD0301 relaxes histamine-contracted guinea pig and human airway smooth muscle and is used in the study of bronchoconstrictive diseases .

HY-P3895

Substance P (3-11)	Neurokinin Receptor	Neurological Disease
Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis .

HY-P3896

Substance P (2-11)	Neurokinin Receptor	Neurological Disease
Substance P (2-11) is a substance P (SP) fragment peptide. Substance P (2-11) has contracting activities on guinea pig ileum. Substance P (2-11) inhibits the permeation of ³H SP in BBMEC monolayers .

HY-P1256

JMV 449	Neurotensin Receptor	Neurological Disease
JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC₅₀ of 0.15 nM for inhibition of [ ¹²⁵I]-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-101303

5-MCA-NAT	Melatonin Receptor	Others
5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP .

HY-P10599

Scyliorhinin I	Neurokinin Receptor	Neurological Disease
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a K_i value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .

HY-113465A

11-trans Leukotriene E4	Endogenous Metabolite	Inflammation/Immunology
11-trans Leukotriene E4 is an isomer of Leukotriene E4 (LTE4). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 is equipotent to LTE4 in contracting guinea pig ileum .

HY-19641

AH13205	Biochemical Assay Reagents Prostaglandin Receptor	Others
AH13205 is a selective prostanoid EP₂-receptor agonist. AH13205 causes concentration-related relaxations of Carbachol (HY-B1208)-contracted trachea. AH13205 causes dose-related protection against Histamine (HY-B1204)-induced increases in respiratory rate .

HY-119926A

13-Hydroxylupanine hydrochloride Hydroxylupanine hydrochloride	Others	Cardiovascular Disease Neurological Disease
13-Hydroxylupanine Hydroxylupanine is the typical alkaloid profile of sweet lupins. 13-Hydroxylupanine Hydroxylupanine blocks ganglionic transmission, decreases cardiac contractility and contracts uterine smooth muscle .

HY-126206

Quazodine MJ-1988	Phosphodiesterase (PDE)	Cardiovascular Disease
Quazodine is a Phosphodiesterase (PDE) inhibitor. Quazodine can be used in vascular smooth muscle related research .

HY-P10279

Anaritide Human atrial natriuretic factor (102–126)	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease Others
Anaritide is a synthetic form of atrial natriuretic peptide (ANP) composed of 25 amino acids. Anaritide increases glomerular filtration rate by dilating into and contracting out the bulbar arterioles. Anaritide can be used to study the effects on patients with acute tubular necrosis, particularly in improving dialysis free survival .

HY-117717

(Rac)-SC-31391	Prostaglandin Receptor	Others
(Rac)-SC-31391, a prostaglandin analog, is a strong activator of the bladder muscle contractility that enhanced twitch responses elicited by field stimulation in the guinea pig detrusor muscle. (Rac)-SC-31391 contracts human bladder muscle through the activation of PGF_2α receptors .

HY-115381

Lipoxin A5	Endogenous Metabolite	Cardiovascular Disease
Lipoxin A5 is an eicosapentaenoic acid derived from pig white blood cells. Lipoxin A5 slowly contracted the guinea pig lung parenchymal strips with a contractile force similar to that of LXA4 and LXB4.2, but LXA5 did not have the vasodilating effect on the aortic smooth muscle shown by LXA4 and LXB4.2 .

HY-W777527

AM404-d4	Isotope-Labeled Compounds Cannabinoid Receptor	Neurological Disease
AM404-d₄ is the deuterium labeled AM404 (HY-101388). AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC₅₀ values in the low micromolar range . AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC₅₀ value of 7.4 (corresponding to an EC₅₀ of 0.04 μM). Neuroprotective Effect .

HY-161836

α2AR agonist 1	Adrenergic Receptor	Cardiovascular Disease
α2AR agonist 1 (compound S6a), a new morpholine-containing pyrimidinone, acts as an agonist of α2-adrenoceptor. α2AR agonist 1 induces a concentration-dependent relaxation on aortic ring pre-contracted with Phenylephrine (HY-B0769; pEC₅₀=6.81). α2AR agonist 1 increases NOx and NO levels in HUVECs .

HY-123801A

MIDD0301 sodium GL-II-93 sodium	GABA Receptor	Inflammation/Immunology
MIDD0301 (GL-II-93) is an orally available, active γ-aminobutyric acid type A receptor (GABA_AR) inhibitor and anti-asthmatic agent. MIDD0301 exhibits biological and immunotoxicological safety in mice and does not affect the number of circulating lymphocytes, monocytes, and granulocytes. MIDD0301 has no significant adverse immune response at repeated doses, which is better than Prednisone (HY-B0214). MIDD0301 relaxes histamine-contracted guinea pig and human airway smooth muscle and is used in the study of bronchoconstrictive diseases .

HY-P3809

[D-Pro2,D-Phe7,D-Trp9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly .

HY-116778

Prostaglandin G2	Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Prostaglandin G2 is a prostaglandin peroxide. Prostaglandin G2 acts as a precursor for thromboxane A₂ production, inducing platelet aggregation and serotonin release. Prostaglandin G2 also induces cerebral arteriole injury in anesthetized cats via the generation of reactive oxygen free radicals, triggering persistent vasodilation, reduced reactivity to hypocapnia, and endothelial damage. Prostaglandin G2 can be used in studies related to cerebral arteriole injury .

HY-N1256

Sculponeatic acid	Others	Others
Sculponeatic acid is a new A-ring contracted oleanane triterpene that can be isolated from Isodon sculponeata .

HY-171831

Leukotriene E3	Endogenous Metabolite	Inflammation/Immunology
Leukotriene E3 is a cysteinyl leukotriene metabolite derived from 5,8,11-eicosatrienoic acid (HY-108398A). Leukotriene E3 acts as a smooth-muscle-contracting mediator. Leukotriene E3 can be used for the research of allergic reactions and asthma .

HY-182613

NSC-2888		Cardiovascular Disease
NSC-2888 is a Rho kinase II (ROCK-II) inhibitor with an IC₅₀ of 8.4 nM against human targets. NSC-2888 inhibits enzymatic activity by binding to active site amino acids via hydrogen bonds and hydrophobic interactions. NSC-2888 induces relaxation of pre-contracted rat aortic strips. NSC-2888 can be used in research related to hypertension .

Cat. No.	Product Name	Target	Research Area