103425-21-4
103425-21-4
Chemical Structure
Scyliorhinin I
- CAS No.: 103425-21-4
- Formula:C59H87N13O13S
- Molecular Weight:1218.47
InChIKey: LSFZLJJVGIYLDA-SRYPMHJGSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](N)C)=O)CCCCN)=O)CC2=CC=CC=C2)=O)=O)=O)CC3=CC=CC=C3)=O
Biological Activity: Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a Ki value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum[1][2].
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Scyliorhinin I | Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a Ki value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum. | |||||||||||||||||||||
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References
- [1]. Conlon, et al. "Scyliorhinin I and II: two novel tachykinins from dogfish gut." FEBS letters 200.1 (1986): 111-116. [Content Brief]
- [2]. Stephen H, et al. "The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors." European journal of pharmacology 144.1 (1987): 109-111. [Content Brief]
