207572-69-8
207572-69-8
Chemical Structure
SB-203186 hydrochloride
- CAS No.: 207572-69-8
- Formula:C16H21ClN2O2
- Molecular Weight:308.80
IUPAC Name: 2-(piperidin-1-yl)ethyl 1H-indole-3-carboxylate hydrochloride
InChIKey: LYMBEMCUJNDSBZ-UHFFFAOYSA-N
SMILES: O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3.Cl
Biological Activity: SB-203186 hydrochloride is a potent, selective and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SB-203186 hydrochloride | 99.94% | SB-203186 hydrochloride is a potent, selective and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively. | ||||||||||||||||||||
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References
- [1]. S G Parker, et al. Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):28-35. [Content Brief]
- [2]. Tohru Komada, et al. Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach. Biol Pharm Bull. 2007 Mar;30(3):508-13. [Content Brief]
- [3]. P G McLean, et al. 5-HT4 receptor antagonist affinities of SB207710, SB205008, and SB203186 in the human colon, rat oesophagus, and guinea-pig ileum peristaltic reflex. Naunyn Schmiedebergs Arch Pharmacol. 1995 Aug;352(2):132-40. [Content Brief]
