190277-13-5
190277-13-5
Chemical Structure
5-MCA-NAT
- CAS No.: 190277-13-5
- Formula:C14H17N3O3
- Molecular Weight:275.30
IUPAC Name: methyl (3-(2-acetamidoethyl)-1H-indol-5-yl)carbamate
InChIKey: MPZVHKLZCUEJFO-UHFFFAOYSA-N
SMILES: O=C(NC1=CC2=C(NC=C2CCNC(C)=O)C=C1)OC
Biological Activity: 5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP[1][2].
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5-MCA-NAT | 5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP. | |||||||||||||||||||||
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References
- [1]. Lucchelli A, et al. Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br J Pharmacol. 1997 Aug;121(8):1775-81. [Content Brief]
- [2]. Serle JB, et al. Effect of 5-MCA-NAT, a putative melatonin MT3 receptor agonist, on intraocular pressure in glaucomatous monkey eyes. J Glaucoma. 2004 Oct;13(5):385-8. [Content Brief]
Keywords
