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Results for "

Dopamine Transporter

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine Receptor (21) Dopamine Transporter (53) 5-HT Receptor (18) Adenylate Cyclase (3) Adrenergic Receptor (13) Akt (1) Amyloid-β (1) Autophagy (1) Bacterial (4) Biochemical Assay Reagents (2) CDK (2) Cytochrome P450 (1) Drug Derivative (3) Drug Intermediate (1) Drug Metabolite (3) Endogenous Metabolite (1) Environmental Pollutants (1) GABA Receptor (1) GPR35 (1) Histamine Receptor (5) Histone Methyltransferase (3) HIV (1) HIV Protease (1) iGluR (1) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (10) mAChR (5) Mitochondrial Metabolism (2) Monoamine Oxidase (5) Monoamine Transporter (12) nAChR (2) NADPH Oxidase (1) Neurotensin Receptor (1) OAT (2) RAR/RXR (2) Reference Standards (17) Serotonin Transporter (37) Sigma Receptor (9) Sodium Channel (7) Trace Amine-associated Receptor (TAAR) (1) Trk Receptor (1) Tyrosine Hydroxylase (4)
By Research Areas:	Cancer (16) Cardiovascular Disease (4) Endocrinology (6) Infection (3) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (120)

By Targets:

Dopamine Receptor (21)

Dopamine Transporter (53)

5-HT Receptor (18)

Adenylate Cyclase (3)

Adrenergic Receptor (13)

Akt (1)

Amyloid-β (1)

Autophagy (1)

Bacterial (4)

Biochemical Assay Reagents (2)

CDK (2)

Cytochrome P450 (1)

Drug Derivative (3)

Drug Intermediate (1)

Drug Metabolite (3)

Endogenous Metabolite (1)

Environmental Pollutants (1)

GABA Receptor (1)

GPR35 (1)

Histamine Receptor (5)

Histone Methyltransferase (3)

HIV (1)

HIV Protease (1)

iGluR (1)

Integrin (1)

Interleukin Related (1)

Isotope-Labeled Compounds (10)

mAChR (5)

Mitochondrial Metabolism (2)

Monoamine Oxidase (5)

Monoamine Transporter (12)

nAChR (2)

NADPH Oxidase (1)

Neurotensin Receptor (1)

OAT (2)

RAR/RXR (2)

Reference Standards (17)

Serotonin Transporter (37)

Sigma Receptor (9)

Sodium Channel (7)

Trace Amine-associated Receptor (TAAR) (1)

Trk Receptor (1)

Tyrosine Hydroxylase (4)

By Research Areas:

Cancer (16)

Cardiovascular Disease (4)

Endocrinology (6)

Infection (3)

Inflammation/Immunology (3)

Metabolic Disease (4)

Neurological Disease (120)

137

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Antibodies

MPP+ iodide Maximum Cited Publications 34 Publications Verification	Mitochondrial Metabolism	Neurological Disease
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .

Vanoxerine dihydrochloride 5+ Cited Publications GBR-12909 dihydrochloride; I893 dihydrochloride	Dopamine Transporter	Neurological Disease
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (K_i=1 nM). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) binds to the target site on the dopamine transporter (DAT) .

Escitalopram 10+ Cited Publications (S)-Citalopram; (S)-(+)-Citalopram	Serotonin Transporter	Neurological Disease
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

Escitalopram oxalate 10+ Cited Publications (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate	Serotonin Transporter	Neurological Disease Cancer
Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

Atomoxetine hydrochloride 4 Publications Verification Tomoxetine hydrochloride; (R)-Tomoxetine hydrochloride; LY 139603	Adrenergic Receptor Serotonin Transporter Sodium Channel	Neurological Disease Cancer
Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with K_i values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .

Benztropine mesylate 5 Publications Verification Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate	Dopamine Receptor mAChR Histamine Receptor	Infection Neurological Disease Metabolic Disease Cancer
Benztropine mesylate (Benzatropine mesylate) is an orally active and BBB-permeable centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D₂ dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .

Desvenlafaxine O-Desmethylvenlafaxine	Environmental Pollutants Serotonin Transporter	Neurological Disease
Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC₅₀ values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

EEDQ EEDQ	Biochemical Assay Reagents 5-HT Receptor Dopamine Transporter	Neurological Disease
EEDQ is a carboxylate activator and irreversible antagonist of 5HT2c receptors. EEDQ reduces [ ³H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates (IC₅₀ = 78.3 μM). EEDQ inhibits contralateral rotation behavior .

Desvenlafaxine succinate hydrate O-Desmethylvenlafaxine succinate hydrate	Serotonin Transporter	Neurological Disease
Desvenlafaxine succinate hydrate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC₅₀ values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate hydrate shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

Dasotraline hydrochloride SEP-225289 hydrochloride	Serotonin Transporter Dopamine Transporter	Neurological Disease
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks *dopamine, norepinephrine, and serotonin* transporters with IC₅₀ values of 4, 6, and 11 nM, respectively.

GBR 12935 dihydrochloride 1 Publications Verification	Dopamine Transporter	Neurological Disease
GBR 12935 dihydrochloride is a potent, and selective dopamine reuptake inhibitor, with the binding constant (K_d) of 1.08 nM in COS-7 cells. GBR 12935 dihydrochloride stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 dihydrochloride also prevents the d-Fenfluramine-induced head-twitch response in mice .

BD-1008	Sigma Receptor	Neurological Disease
BD-1008 is a nonselective σ receptor antagonist with K_is against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 has an extremely low affinity for the D2 receptor (K_i = 1112 nM) and dopamine transporter (DAT) (K_i > 10,000 nM). BD-1008 significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 blocks the self-administration behavior of σ agonists.BD-1008 can be used for the study of addiction therapy that target the σ receptor .

Centanafadine hydrochloride EB-1020 hydrochloride	Adrenergic Receptor Dopamine Transporter Serotonin Transporter	Neurological Disease Endocrinology
Centanafadine (hydrochloride) is dual *norepinephrine (NE)/dopamine* (DA)** transporter inhibitor, also inhibits serotonin transporter, with IC₅₀s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.

Benztropine 5 Publications Verification Benzatropine; Benzotropine	Dopamine Receptor mAChR Histamine Receptor	Cancer
Benztropine (Benzatropine; Benzotropine) is an orally active and BBB-permeable centrally acting anticholinergic agent that can be used for Parkinson's disease research . Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D₂ dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .

D-Tetrahydropalmatine 1 Publications Verification	Dopamine Receptor	Metabolic Disease
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis . D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent *organic cation transporter* 1 (OCT1)** inhibitor .

AHN 1-055 hydrochloride 3 Publications Verification 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride	Dopamine Transporter	Neurological Disease
AHN 1-055 hydrochloride is a dopamine uptake inhibitor that can cross the blood-brain barrier, with an IC₅₀ of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) .

J147	Monoamine Oxidase Dopamine Transporter	Neurological Disease
J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB). J147 can inhibit monoamine oxidase B (MAO B) and the **dopamine transporter**. J147 plays an impotant role in Alzheimer’s disease (AD) .

13-Hydroxyisobakuchiol Delta3,2-Hydroxylbakuchiol	Monoamine Transporter Dopamine Transporter	Neurological Disease
13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) that can be isolated from Psoralea corylifolia (L.), is a potent selective monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC₅₀ = 0.58 μM) and norepinephrine transporter (NET) (IC₅₀ = 0.69 μM) than for the serotonin transporter (SERT) (IC₅₀ = 312.02 μM). 13-Hydroxyisobakuchiol increases the activity of intact mice and improves the decreased activity of reserpinized mice in vivo. 13-Hydroxyisobakuchiol can be used for the research of disorders such as Parkinson's disease and depression .

LH2-051	Dopamine Transporter CDK	Neurological Disease
LH2-051, a lysosome-enhancing compound (LYEC), is a brain-penetrant **dopamine transporter (DAT) inhibitor (K_i: 0.95 μM). LH2-051 inhibits DAT*-mediated dopamine* uptake with an IC₅₀ of 3.0 μM. LH2-051 promotes nuclear translocation of TFEB and lysosome biogenesis. LH2-051 improves the memory of amyloid precursor protein (APP)/Presenilin 1 (PS1) mice. LH2-051 can be used for the study of Alzheimer’s disease .

Indatraline hydrochloride Lu 19-005	Serotonin Transporter Dopamine Transporter	Neurological Disease
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis .

Vanoxerine 5+ Cited Publications GBR 12909; I893	Dopamine Transporter	Neurological Disease
Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (K_i=1 nM). Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT) .

5,7-Dimethoxyluteolin	Dopamine Transporter	Neurological Disease
5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin derivative, is a dopamine transporter (DAT) activator with an EC₅₀ of 3.417 μM .

Rimcazole dihydrochloride BW 234U dihydrochloride	Sigma Receptor Dopamine Receptor	Neurological Disease Cancer
Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the **dopamine transporter** and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer .

Escitalopram oxalate (Standard) (S)-Citalopram oxalate (Standard); (S)-(+)-Citalopram oxalate (Standard)	Reference Standards Serotonin Transporter	Neurological Disease Cancer
Escitalopram (oxalate) (Standard) is the analytical standard of Escitalopram (oxalate). This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

(-)-Isocorypalmine Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine	Dopamine Receptor	Others Neurological Disease
(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research .

Atomoxetine 4 Publications Verification Tomoxetine; (R)-Tomoxetine	Serotonin Transporter Sodium Channel	Neurological Disease Cancer
Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .

JJC8-088 dioxalate	Dopamine Transporter	Neurological Disease
JJC8-088 dioxalate is the dioxalate salt form of JJC8-088 (HY-158013). JJC8-088 dioxalate is a derivative of modafinil. JJC8-088 dioxalate is an inhibitor for **dopamine transporter (DAT**). JJC8-088 dioxalate exhibits behavioral characteristics similar to cocaine in rat models, and can be to study psychostimulant use disorders .

Radafaxine hydrochloride 1 Publications Verification (S,S)-Hydroxybupropion hydrochloride; GW-353162A; BW-306U	Monoamine Transporter	Neurological Disease
Radafaxine hydrochloride (GW-353162A) is a DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.

Nitracaine	Dopamine Receptor	Neurological Disease
Nitracaine is a structural analog of Dimethocaine (HY-121870), a local anesthetic that inhibits dopamine reuptake through the dopamine transporter .

Centanafadine EB-1020	Adrenergic Receptor Dopamine Transporter Serotonin Transporter	Neurological Disease Endocrinology
Centanafadine is dual *norepinephrine (NE)/dopamine* (DA)** transporter inhibitor, also inhibits serotonin transporter, with IC₅₀s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.

Amfonelic acid WIN-25978	Biochemical Assay Reagents	Neurological Disease
Amfonelic acid (WIN-25978) is a highly selective *dopamine* reuptake inhibitor. Amfonelic acid interferes with the in vitro neuronal uptake of norepinephrine in the iris of rats, but does not alter the concentrations of norepinephrine or dopamine in the whole mouse brain. Amfonelic acid can be used as a pharmacological tool to study the brain reward system, dopamine pathway and dopamine transporter .

(R)-Phenylpiracetam MRZ 9547	Dopamine Transporter	Neurological Disease Inflammation/Immunology
(R)-Phenylpiracetam (MRZ 9547) is a dopamine transporter (DAT) inhibitor (K_i: 14.8 μM; IC₅₀: 65.5 μM). (R)-Phenylpiracetam can be used for the research of the neurological or neuropsychiatric disorders .

SRI-31142	Dopamine Transporter	Neurological Disease
SRI-31142 is a putative, brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies using intracranial self-stimulation (ICSS), SRI-31142 did not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses. SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine .

Amitriptyline-d3 hydrochloride	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease
Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of *serotonin reuptake transporter* (SERT) and noradrenaline reuptake transporter (NET), with K_i*s of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine* reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity .

Bupropion morpholinol	Dopamine Transporter nAChR	Neurological Disease
Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits *Dopamine, Norepinephrine transporters* and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities .

MPP+-d3iodide	Mitochondrial Metabolism	Neurological Disease
MPP+-d₃ (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .

4-Methylamphetamine hydrochloride 4-MA hydrochloride	5-HT Receptor Monoamine Transporter Dopamine Receptor	Neurological Disease
4-Methylamphetamine hydrochloride is a 5-HT1A receptor agonist that induces hypothermia in rats by binding to the 5-HT1A receptor. Additionally, 4-Methylamphetamine hydrochloride acts on norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters to increase the extracellular levels of these neurotransmitters. 4-Methylamphetamine hydrochloride can be used in the study of neurological disorders .

(S)-CE-123	Dopamine Transporter	Neurological Disease
(S)-CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC₅₀ of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S)-CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S)-CE-123 improves cognitive and motivational processes in experimental animals .

Z1078601926	Dopamine Transporter	Neurological Disease
Z1078601926 is an allosterical inhibitor of human dopamine transporter (hDAT). Z1078601926 has synergistic effect with Nomifensine (HY-B1110) .

JJC8-088	Dopamine Transporter	Neurological Disease
JJC8-088, a Modafinil-derived ligand, is a dopamine transporter (DAT) inhibitor with a K_i of 2.53 nM. JJC8-088 dioxalate can be to study psychostimulant use disorders .

Escitalopram-d6 oxalate	Serotonin Transporter	Neurological Disease
Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

Ampreloxetine hydrochloride TD-9855 hydrochloride	Serotonin Transporter	Neurological Disease
Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not **Dopamine transporter** (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC₅₀ values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma .

JJC8-089	Dopamine Transporter	Neurological Disease
JJC8-089 is a dopamine transporter (DAT) inhibitor that may improve motivational dysfunction and increase effortful behavior in goal-directed activities. JJC8-089 significantly reversed the low-effort effects induced by the VMAT-2 inhibitor Tetrabenazine (HY-B0590) in rats and increased the choice of high-effort fixed-ratio 5-bar presses versus food intake. .

DOV-102,677	Dopamine Transporter Adrenergic Receptor 5-HT Receptor	Neurological Disease
DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC₅₀ = 129 nM; K_i = 222 nM), norepinephrine (NET) (IC₅₀ = 103 nM; K_i = 1030 nM), and serotonin (SERT) (IC₅₀ = 133 nM; K_i = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression .

Cendifensine	Monoamine Transporter Serotonin Transporter Dopamine Transporter	Neurological Disease
Cendifensine is the inhibitor for monoamine reuptake that inhibits the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14258

Escitalopram 10+ Cited Publications (S)-Citalopram; (S)-(+)-Citalopram	Natural Products Endogenous metabolite Source Classification	Serotonin Transporter
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-B0927

Hydrastine (-)-β-Hydrastine; (1R,9S)-β-Hydrastine	Alkaloids Piperidine Alkaloids Classification of Application Fields Ranunculaceae Other Diseases Plants Disease Research Fields	Tyrosine Hydroxylase Dopamine Receptor OAT
Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting *dopamine* biosynthesis (IC₅₀=20.7 μM, PC12 cells). Hydrastine also inhibits the *organic cation transporter* OCT1 (IC₅₀=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis** when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .

HY-N2003

D-Tetrahydropalmatine 1 Publications Verification	Alkaloids Corydalis yanhusuo W. T. Wang Classification of Application Fields Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Dopamine Receptor
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis . D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent *organic cation transporter* 1 (OCT1)** inhibitor .

HY-N7506

13-Hydroxyisobakuchiol Delta3,2-Hydroxylbakuchiol	Structural Classification Monophenols Leguminosae Phenols Psoralea corylifolia L. Plants Source Classification	Monoamine Transporter Dopamine Transporter
13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) that can be isolated from Psoralea corylifolia (L.), is a potent selective monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC₅₀ = 0.58 μM) and norepinephrine transporter (NET) (IC₅₀ = 0.69 μM) than for the serotonin transporter (SERT) (IC₅₀ = 312.02 μM). 13-Hydroxyisobakuchiol increases the activity of intact mice and improves the decreased activity of reserpinized mice in vivo. 13-Hydroxyisobakuchiol can be used for the research of disorders such as Parkinson's disease and depression .

HY-111928

5,7-Dimethoxyluteolin	Flavonoids Flavones Phenols Polyphenols Plants Bauhinia purpurea L. Compositae Source Classification	Dopamine Transporter
5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin derivative, is a dopamine transporter (DAT) activator with an EC₅₀ of 3.417 μM .

HY-N0927

(-)-Isocorypalmine Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine	Alkaloids Structural Classification Monophenols other families Classification of Application Fields Other Diseases Phenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Dopamine Receptor
(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research .

HY-14258R

Escitalopram (Standard) (S)-Citalopram (Standard); (S)-(+)-Citalopram (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Serotonin Transporter Reference Standards
Escitalopram (Standard) is the analytical standard of Escitalopram. This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-N2426R

Clerodendrin (Standard)	Clerodendrum trichotomum Thunb. Flavonoids Verbenaceae Plants Isoflavones	Reference Standards Interleukin Related
Desvenlafaxine (Standard) is the analytical standard of Desvenlafaxine. This product is intended for research and analytical applications. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-B0927R

Hydrastine (Standard) (-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard)	Structural Classification Alkaloids Piperidine Alkaloids Ranunculaceae Plants	Reference Standards Tyrosine Hydroxylase Dopamine Receptor OAT
Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting *dopamine* biosynthesis (IC₅₀=20.7 μM, PC12 cells). Hydrastine also inhibits the *organic cation transporter* OCT1 (IC₅₀=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis** when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .

Cat. No.	Product Name	Chemical Structure

HY-12766S

Bupropion morpholinol-d6
Bupropion morpholinol-d6 is the deuterated form of Bupropion morpholinol. Bupropion morpholinol is a major metabolite of Bupropion. Bupropion morpholinol inhibits *Dopamine, Norepinephrine transporters* and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities .

HY-W008719S

MPP+-d3iodide

MPP+-d₃ (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .

HY-14258AS

Escitalopram-d6 oxalate

Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-B0457S

Clomipramine-d3 hydrochloride
Clomipramine-d₃ (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-B0457AS

Clomipramine-d3
Clomipramine-d₃ is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-14258AS1

Escitalopram-d4 oxalate

Escitalopram-d₄ (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-B0602S2

Desvenlafaxine-d6

Desvenlafaxine-d₆ is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC₅₀ values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-B0602S3

Desvenlafaxine-d10

Desvenlafaxine-d₁₀ is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC₅₀ values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-107370S

Atomoxetine-d7

Atomoxetine-d₇ (Tomoxetine-d₇) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .

HY-107370S1

Atomoxetine-d5

Atomoxetine-d₅ (Tomoxetine-d₅) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .

HY-100966S

BD-1008-d5 dihydrobromide

BD-1008-d₅ dihydrobromide is the deuterium labeled BD-1008 dihydrobromide (HY-100966). BD-1008 dihydrobromide is a nonselective σ receptor antagonist with K_is against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 dihydrobromide has an extremely low affinity for the D2 receptor (K_i = 1112 nM) and dopamine transporter (DAT) (K_i > 10,000 nM). BD-1008 dihydrobromide significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 dihydrobromide blocks the self-administration behavior of σ agonists.BD-1008 dihydrobromide can be used for the study of addiction therapy that target the σ receptor .

HY-W748758

(Z)-Thiothixene-d8

(Z)-Thiothixene-d₈ (NSC 108165-d₈; Navan-d₈; Navane-d₈) is the deuterium labeled Thiothixene (HY-A0139). Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.

HY-17385S1

Atomoxetine-d7 hydrochloride

Atomoxetine-d₇ hydrochloride (Tomoxetine-d₇ hydrochloride) is the deuterium labeled Atomoxetine hydrochloride (HY-17385). Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with K_i values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .

Host:	Rat (1) Rabbit (3)
Reactivity:	Human (1) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (1) IP (1) IHC-F (3) WB (3) FC (1) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (4)
Clonality:	Polyclonal (1) Monoclonal (2) Recombinant (3)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81165

	Dopamine Transporter Antibody DA Transporter; DAT 1; DAT; DAT1; SC6A3_HUMAN; SLC6A3; Sodium dependent Dopamine Transporter; Sodium-dependent Dopamine Transporter; Solute carrier family 6 (neurotransmitter Transporter Dopamine), member 3; Solute carrier family 6 member 3; Variable number tandem repeat (VNTR); Dopamine Transporter; ADAT 1; Adenosine deaminase tRNA specific 1; HADAT1; tRNA specific adenosine deaminase 1.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	Dopamine Transporter Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Dopamine Transporter.

HY-P88026

	Dopamine Transporter Antibody (YA7711)	FC, IP
	Dopamine Transporter Antibody (YA7711) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dopamine Transporter.

HY-P86855

	Dopamine Transporter Antibody (YA6548) DA Transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine Transporter 1 antibody; Dopamine Transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent Dopamine Transporter antibody; DA Transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine Transporter 1 antibody; Dopamine Transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent Dopamine Transporter antibody; Sodium-dependent Dopamine Transporter antibody; Solute carrier family 6 (neurotransmitter Transporter Dopamine), member 3 antibody; Solute carrier family 6 (neurotransmitter Transporter), member 3 antibody; Solute carrier family 6 member 3 antibody; Variable number tandem repeat (VNTR) antibody;	IHC-F, IHC-P, WB	Mouse, Rat
	Dopamine Transporter Antibody (YA6548) is a Rat -derived and non-conjugated monoclonal antibody, targeting to Dopamine Transporter.

HY-P86856

	Dopamine Transporter Antibody (YA6549) DA Transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine Transporter 1 antibody; Dopamine Transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent Dopamine Transporter antibody; DA Transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine Transporter 1 antibody; Dopamine Transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent Dopamine Transporter antibody; Sodium-dependent Dopamine Transporter antibody; Solute carrier family 6 (neurotransmitter Transporter Dopamine), member 3 antibody; Solute carrier family 6 (neurotransmitter Transporter), member 3 antibody; Solute carrier family 6 member 3 antibody; Variable number tandem repeat (VNTR) antibody;	WB, IHC-F, IHC-P	Mouse, Rat
	Dopamine Transporter Antibody (YA6549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dopamine Transporter.

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