410074-74-7
410074-74-7
Chemical Structure
Amitifadine hydrochloride
Synonym(s): DOV-21947 hydrochloride; EB-1010 hydrochloride
- CAS No.: 410074-74-7
- Formula:C11H12Cl3N
- Molecular Weight:264.58
IUPAC Name: (1R,5S)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride
InChIKey: KAGBHVBIOJBGBD-NINOIYOQSA-N
SMILES: ClC(C=C1[C@]2(CNC3)[C@@H]3C2)=C(C=C1)Cl.[H]Cl
Biological Activity: Amitifadine (DOV-21947; EB-1010) hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.
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Amitifadine hydrochloride | 99.64% | Amitifadine (DOV-21947; EB-1010) hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively. | ||||||||||||||||||||
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3,4-DCMC hydrochloride | 3,4-Dichloromethcathinone hydrochloride is a drug derivative. | |||||||||||||||||||||
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Centanafadine | 99.62% | Centanafadine is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. | ||||||||||||||||||||
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Centanafadine hydrochloride | 99.55% | Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. | ||||||||||||||||||||
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Amitifadine | Amitifadine (DOV-21947; EB-1010) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively. | |||||||||||||||||||||
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DOV-102,677 | DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC50 = 129 nM; Ki = 222 nM), norepinephrine (NET) (IC50 = 103 nM; Ki = 1030 nM), and serotonin (SERT) (IC50 = 133 nM; Ki = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression. | |||||||||||||||||||||
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DOV-216,303 Free Base | 98.17% | DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats. | ||||||||||||||||||||
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(3,4-Dichlorophenyl)methanol (Standard) | ≥98% | (3,4-Dichlorophenyl)methanol (Standard) is the analytical standard of (3,4-Dichlorophenyl)methanol. This product is intended for research and analytical applications. | ||||||||||||||||||||
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DOV-216,303 | DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats. | |||||||||||||||||||||
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4-(4-Chlorophenyl)pyrrolidin-2-one (Standard) | ≥98% | 4-(4-Chlorophenyl)pyrrolidin-2-one (Standard) is the analytical standard of 4-(4-Chlorophenyl)pyrrolidin-2-one. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Bicifadine | Bicifadine is an orally active serotonin/norepinephrine/dopamine triple reuptake inhibitor. Bicifadine is an effective antinociceptive in several models of acute, persistent, and chronic pain. | |||||||||||||||||||||
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