16357-59-8
16357-59-8
Chemical Structure
EEDQ
Synonym(s): EEDQ
- CAS No.: 16357-59-8
- Formula:C14H17NO3
- Molecular Weight:247.29
IUPAC Name: ethyl 2-ethoxyquinoline-1(2H)-carboxylate
InChIKey: GKQLYSROISKDLL-UHFFFAOYSA-N
SMILES: O=C(N1C(OCC)C=CC2=C1C=CC=C2)OCC
Biological Activity: EEDQ is a carboxylate activator and irreversible antagonist of 5HT2c receptors. EEDQ reduces [3H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates (IC50 = 78.3 μM). EEDQ inhibits contralateral rotation behavior[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EEDQ | 99.97% | EEDQ is a carboxylate activator and irreversible antagonist of 5HT2c receptors. EEDQ reduces [3H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates (IC50 = 78.3 μM). EEDQ inhibits contralateral rotation behavior. | ||||||||||||||||||||
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References
- [1]. Hughes B P, et al. Effects of N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) on agonist-stimulated Ca2+ inflow across the hepatocyte plasma membrane. Biochemical pharmacology, 1991, 41(6-7): 1087-1090.
- [2]. Ni YG, et al. Irreversible antagonism of 5HT2c receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2715-8. [Content Brief]
- [3]. Tarazi FI, et al. Alkylation of rat dopamine transporters and blockade of dopamine uptake by EEDQ. Neuropharmacology. 2000 Aug 23;39(11):2133-8. [Content Brief]
- [4]. Goodale DB, et al. Selective protection from the inhibition by EEDQ of D1 and D2 dopamine agonist-induced rotational behavior in mice. Pharmacol Biochem Behav. 1988 Jun;30(2):457-62. [Content Brief]
- [5]. Mestlin M, et al. Ontogenetic differences in the effects of EEDQ on dopamine-mediated behaviors. Pharmacol Biochem Behav. 1993 Aug;45(4):797-802. [Content Brief]
Keywords
