16357-59-8
16357-59-8
Chemical Structure
EEDQ
Synonym(s): EEDQ
- CAS No.: 16357-59-8
- Formula:C14H17NO3
- Molecular Weight:247.29
IUPAC Name: ethyl 2-ethoxyquinoline-1(2H)-carboxylate
InChIKey: GKQLYSROISKDLL-UHFFFAOYSA-N
SMILES: O=C(N1C(OCC)C=CC2=C1C=CC=C2)OCC
Biological Activity: EEDQ is a carboxylate activator and irreversible antagonist of 5HT2c receptors. EEDQ reduces [3H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates (IC50 = 78.3 μM). EEDQ inhibits contralateral rotation behavior[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EEDQ | 99.97% | EEDQ is a carboxylate activator and irreversible antagonist of 5HT2c receptors. EEDQ reduces [3H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates (IC50 = 78.3 μM). EEDQ inhibits contralateral rotation behavior. | ||||||||||||||||||||
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HIV-IN-4 | HIV-IN-4 (Compound 12) is a potent inhibitor of HIV. HIV-IN-4 shows promising anti-HIV activities. | |||||||||||||||||||||
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Methamphetamine ethyl carbamate | Methamphetamine ethyl carbamate is an amphetamine. This product is intended for research and forensic applications. | |||||||||||||||||||||
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1-Boc-6-Amino-2,3-dihydroindole | 98.67% | 1-Boc-6-Amino-2,3-dihydroindole (tert-Butyl 6-aminoindoline-1-carboxylate) is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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Ethyl 4-(piperazin-1-yl)benzoate | Ethyl 4-(piperazin-1-yl)benzoate is a PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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NadD-IN-1 | NadD-IN-1 is a bacterial NadD inhibitor. NadD-IN-1 can be used for the research of bacterial infections. | |||||||||||||||||||||
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Benzyl 3-(hydroxymethyl)azetidine-1-carboxylate | 96.80% | Benzyl 3-(hydroxymethyl)azetidine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs. | ||||||||||||||||||||
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1-Cbz-Azetidine-3-CH2NH2 | 1-Cbz-Azetidine-3-CH2NH2 is a PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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References
- [1]. Hughes B P, et al. Effects of N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) on agonist-stimulated Ca2+ inflow across the hepatocyte plasma membrane. Biochemical pharmacology, 1991, 41(6-7): 1087-1090.
- [2]. Ni YG, et al. Irreversible antagonism of 5HT2c receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2715-8. [Content Brief]
- [3]. Tarazi FI, et al. Alkylation of rat dopamine transporters and blockade of dopamine uptake by EEDQ. Neuropharmacology. 2000 Aug 23;39(11):2133-8. [Content Brief]
- [4]. Goodale DB, et al. Selective protection from the inhibition by EEDQ of D1 and D2 dopamine agonist-induced rotational behavior in mice. Pharmacol Biochem Behav. 1988 Jun;30(2):457-62. [Content Brief]
- [5]. Mestlin M, et al. Ontogenetic differences in the effects of EEDQ on dopamine-mediated behaviors. Pharmacol Biochem Behav. 1993 Aug;45(4):797-802. [Content Brief]
