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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
E. coli GyrB
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "E. coli GyrB" in MCE Product Catalog:
Cat. No.: HY-182936
Target:
Research Areas:
Antibacterial agent 338 (Compound 65) is an antibacterial agent and GyrB inhibitor, with an IC50 of 12.60 nM against GyrB from E. coli. Antibacterial agent 338 binds to the ATP-binding domain of E. coli GyrB, thereby inhibiting the ATPase activity of GyrB. Antibacterial agent 338 exhibits broad-spectrum antibacterial activity against multidrug-resistant Gram-negative bacteria. Antibacterial agent 338 reduces bacterial load in a neutropenic mouse thigh infection model. Antibacterial agent 338 can be used for the research of Acinetobacter baumannii infection .
Cat. No.: HY-P701907
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DNA gyrase subunit B; EC:5.6.2.2; Type IIA topoisomerase subunit GyrB; GyrB; acrB; cou; himB; hisU; nalC; parA; pcbA; b3699; JW5625
Species:
E.coli
Source:
E. coli
Cat. No.: HY-P701908
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DNA gyrase subunit B; EC:5.6.2.2; Type IIA topoisomerase subunit GyrB; GyrB; acrB; cou; himB; hisU; nalC; parA; pcbA; b3699; JW5625
Species:
E.coli
Source:
E. coli
Cat. No.: HY-187561
Antibacterial agent 365 is a benzothiazole-based antibacterial agent that primarily exerts its effects by disrupting bacterial cell membranes. Antibacterial agent 365 exhibits a MIC of 4 μg/mL against Staphylococcus aureus ATCC 29213, MRSA ATCC BAA41 and MRSA ATCC 43300. Antibacterial agent 365 can be used in studies of MRSA infection, bacterial cell membrane disruption, biofilm formation and antimicrobial resistance .
Cat. No.: HY-189125
Target:
Anticancer agent 360 is a broad-spectrum antibacterial agent. Anticancer agent 360 binds to the ATP pocket of the GyrB subunit of DNA gyrase via an Arg84 salt bridge, interfering with gyrase-dependent DNA supercoiling. Anticancer agent 360 disrupts bacterial biofilms and inhibits the metabolic activity of respiratory chain dehydrogenases. Anticancer agent 360 exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and fungal strains. Anticancer agent 360 exerts selective cytotoxicity against liver cancer cells. Anticancer agent 360 can be used in studies related to bacterial infections and liver cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
