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Results for "

FGF21

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

2

Inhibitory Antibodies

13

Recombinant Proteins

1

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99930
    Efruxifermin
    2 Publications Verification

    AKR-001; AMG-876

    		 FGFR Metabolic Disease
    Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis .
    Efruxifermin
  • HY-P990964
    Efimosfermin alfa

    BOS-580; LLF580

    		 FGFR Metabolic Disease Inflammation/Immunology
    Efimosfermin alfa is a genetically engineered FGF21 variant. Efimosfermin alfa exerts its function by activating the FGFR1c/β-Klotho complex. Efimosfermin alfa is applicable to researches on metabolic dysfunction-associated steatohepatitis, obesity and mild hypertriglyceridemia .
    Efimosfermin alfa
  • HY-107574
    TC-E 5003
    3 Publications Verification

    		 Histone Methyltransferase AP-1 NF-κB PKA Metabolic Disease Inflammation/Immunology Cancer
    TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 modulates the lipopolysaccharide (LPS) (HY-D1056)-induced AP-1 and NF-κB signaling pathways with anti-inflammatory properties. TC-E 5003 also upregulates the expression of Ucp1 and Fgf21, activates protein kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. TC-E 5003 is promising for research of obesity and associated metabolic disorders, oxidative stress, inflammation and cancers .
    TC-E 5003
  • HY-125366
    ARI-3099

    		FAP Metabolic Disease
    ARI-3099 is an oral fibroblast activation protein (FAP) inhibitor. ARI-3099 specifically inhibits the proteolytic activity of FAP and blocks the cleavage of human FGF-21 between residues P171 and S172. ARI-3099 extends the half-life of circulating human FGF-21 in mice. ARI-3099 can be used in the research of type 2 diabetes and metabolic disorders .
    ARI-3099
  • HY-174700
    Human FGF21 mRNA

    		mRNA Cancer
    Human FGF21 mRNA encodes the human fibroblast growth factor 21 (FGF21) protein, a member of the fibroblast growth factor (FGF) family. FGF21 is a secreted endocrine factor that functions as a major metabolic regulator. It stimulates the uptake of glucose in adipose tissue.
    Human FGF21 mRNA
  • HY-173463
    Sirtuin modulator 8

    		Sirtuin Metabolic Disease Inflammation/Immunology
    Sirtuin modulator 8 is a sirtuin modulator that can activate Sirtuin activity. Sirtuin modulator 8 significantly downregulates the expression of monocyte chemoattractant protein-1 (MCP-1) and upregulates the expression of fibroblast growth factor 21 (FGF21). Sirtuin modulator 8 regulates the expression of inflammation- and metabolism-related genes, showing potential for studying metabolic diseases (such as diabetes, obesity) and inflammatory diseases .
    Sirtuin modulator 8
  • HY-RS16539
    Fgf21 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fgf21 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fgf21 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fgf21 Mouse Pre-designed siRNA Set A
    Fgf21 Mouse Pre-designed siRNA Set A
  • HY-RS04898
    FGF21 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FGF21 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FGF21 Human Pre-designed siRNA Set A
    FGF21 Human Pre-designed siRNA Set A
  • HY-RS22971
    Fgf21 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fgf21 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fgf21 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fgf21 Rat Pre-designed siRNA Set A
    Fgf21 Rat Pre-designed siRNA Set A
  • HY-183331
    YXX0237

    		Others Infection Inflammation/Immunology
    YXX0237 is an orally active anti-hypoxic agent. YXX0237 upregulates mRNA expression of FGF21 and GDF15 via activation of the ISR/ATF4 transcriptional axis. YXX0237 exhibits low cytotoxicity. YXX0237 enhances hypoxic survival in mice. YXX0237 can be used for the research of acute mountain sickness and hypoxia-related diseases .
    YXX0237
  • HY-183332
    YXX0248

    		Others Inflammation/Immunology
    YXX0248 is an orally active anti-hypoxic agent. YXX0248 upregulates mRNA expression of FGF21 and GDF15 via activation of the ISR/ATF4 transcriptional axis. YXX0248 exhibits low cytotoxicity. YXX0248 enhances hypoxic survival in mice. YXX0248 can be used for the research of acute mountain sickness and hypoxia-related diseases .
    YXX0248
  • HY-107574R
    TC-E 5003 (Standard)

    		Reference Standards Histone Methyltransferase AP-1 NF-κB PKA Metabolic Disease Inflammation/Immunology Cancer
    TC-E 5003 (Standard) is the analytical standard of TC-E 5003 (HY-107574). This product is intended for research and analytical applications. TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 modulates the lipopolysaccharide (LPS) (HY-D1056)-induced AP-1 and NF-κB signaling pathways with anti-inflammatory properties. TC-E 5003 also upregulates the expression of Ucp1 and Fgf21, activates protein Kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. TC-E 5003 is promising for research of obesity and associated metabolic disorders, oxidative stress, inflammation and cancers .
    TC-E 5003 (Standard)

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