35 Results for "

Fas receptor

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "Fas receptor" in MCE Product Catalog:

  • Targets Recommended:
4
4 Cited Publications
Cat. No.: HY-103243
CAS No.: 76150-91-9
Purity:  98.42%
Target:  

Bcl-2 Family

Research Areas:  

Cancer

TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss . TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-101849
CAS No.: 392721-37-8
Purity:  ≥98.0%
Research Areas:  

Cardiovascular Disease Cancer

Fasentin, a potent glucose uptake inhibitor, inhibits GLUT-1/GLUT-4 transporters. Fasentin preferentially inhibits GLUT4 (IC50=68 μM) over GLUT1. Fasentin is a death receptor stimuli (FAS) sensitizer and sensitizes cells to FAS-induced cell death. Fasentin is also a tumor necrosis factor (TNF) apoptosis-inducing ligand sensitizer. Fasentin blocks glucose uptake in cancer cell lines and has anti-angiogenic activity .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P10102
CAS No.: 629628-53-1
Research Areas:  

Inflammation/Immunology Cancer

Kp7-6 is a Fas mimetic peptide and also a Fas/FasL antagonist. Kp7-6 specifically binds to Fas and FasL, disrupts receptor complexes, and blocks downstream apoptosis signaling pathways. Kp7-6 inhibits the phosphorylation of ERK1-2, induces the phosphorylation of IκBα, and activates NF-κB. Kp7-6 inhibits the activation of caspase-8, caspase-3 and JNK, and suppresses human amylin-induced β-cell apoptosis. Kp7-6 inhibits FasL-induced lymphoid cytotoxicity and apoptosis. Kp7-6 reduces local tumor FasL expression, increases CD8 +Fas + T cell infiltration, and decreases tumor volume in pancreatic neuroendocrine tumor models. Kp7-6 prevents concanavalin A-induced liver injury in mice. Kp7-6 is applicable to research related to type 2 diabetes, concanavalin A-induced hepatitis and pancreatic neuroendocrine tumors .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N0686
CAS No.: 102115-79-7
Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P6440
CAS No.: 1242964-46-0
Target:  

Apoptosis Caspase

Research Areas:  

Others

Met-12 is a small peptide inhibitor of the Fas receptor. Met-12 can inhibit Fas receptor-mediated photoreceptor cell apoptosis, reduce Caspase activation. Met-12 can be used in the research of photoreceptor .
loading...
    loading...
Cat. No.: HY-P10227
CAS No.: 2040964-58-5
Synonyms: ONL-1204
Xelafaslatide (ONL-1204) is a Fas receptor antagonist. Xelafaslatide blocks the Fas receptor signaling pathway and inhibits downstream apoptosis and inflammatory pathways. Xelafaslatide suppresses neuroinflammation and microglial activation in glaucoma models, protects retinal ganglion cells and prevents axonal degeneration. Xelafaslatide is applicable to relevant research on glaucoma .
loading...
    loading...
Cat. No.: HY-108610C
CAS No.: 83542-43-2
Synonyms: (S)-ET-18-OCH3
Target:  

Apoptosis

Research Areas:  

Cancer

(S)-Edelfosine ((S)-ET-18-OCH3) is the (S)-enantiomer of Edelfosine (ET-18-OCH3) (HY-108610C). Edelfosine is a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 Death receptor .
loading...
    loading...
Cat. No.: HY-146197
CAS No.: 2490538-26-4
Target:  

Apoptosis

Research Areas:  

Cancer

Apoptotic agent-1 (Compound 8a) is an apoptotic agent with high antiproliferative activity against cancer cells and low cytotoxic effect. Apoptotic agent-1 induces over-expression of Fas receptor and Cyto C genes .
loading...
    loading...
Cat. No.: HY-101849R
CAS No.: 392721-37-8
Fasentin (Standard) is the analytical standard of Fasentin. This product is intended for research and analytical applications. Fasentin, a potent glucose uptake inhibitor, inhibits GLUT-1/GLUT-4 transporters. Fasentin preferentially inhibits GLUT4 (IC50=68 μM) over GLUT1. Fasentin is a death receptor stimuli (FAS) sensitizer and sensitizes cells to FAS-induced cell death. Fasentin is also a tumor necrosis factor (TNF) apoptosis-inducing ligand sensitizer. Fasentin blocks glucose uptake in cancer cell lines and has anti-angiogenic activity .
loading...
    loading...
Cat. No.: HY-103243R
CAS No.: 76150-91-9
Research Areas:  

Cancer

TCPOBOP (Standard) is the analytical standard of TCPOBOP. This product is intended for research and analytical applications. TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss . TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins .
loading...
    loading...
Cat. No.: HY-N0686R
CAS No.: 102115-79-7
Pseudoprotodioscin (Standard) is the analytical standard of Pseudoprotodioscin. This product is intended for research and analytical applications. Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides .
loading...
    loading...
Cat. No.: HY-168770
CAS No.: 862377-51-3
Research Areas:  

Cardiovascular Disease

Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO). Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases .
loading...
    loading...
Cat. No.: HY-174714
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human FAS mRNA encodes the human Fas cell surface death receptor (FAS) protein, a member of the TNF-receptor superfamily. FAS has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.
loading...
    loading...
Cat. No.: HY-P7169
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Fas; Fas (TNF receptor Superfamily, Member 6); Prev. TNFRSF6; Apoptosis Signaling receptor Fas; Prev. APT1; Apo-1 Antigen; Prev. Fas1; CD95 Antigen; Tumor Necrosis Factor receptor Superfamily Member 6; Mutant Tumor Necrosis receptor Superfamily Member 6;
Species:  
Human
Source:  
E. coli
loading...
    loading...
Cat. No.: HY-P7168
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Fas; Fas (TNF receptor Superfamily, Member 6); Prev. TNFRSF6; Apoptosis Signaling receptor Fas; Prev. APT1; Apo-1 Antigen; Prev. Fas1; CD95 Antigen; Tumor Necrosis Factor receptor Superfamily Member 6; Mutant Tumor Necrosis receptor Superfamily Member 6;
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P76330
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Fas; Fas (TNF receptor Superfamily, Member 6); Prev. TNFRSF6; Apoptosis Signaling receptor Fas; Prev. APT1; Apo-1 Antigen; Prev. Fas1; CD95 Antigen; Tumor Necrosis Factor receptor Superfamily Member 6; Mutant Tumor Necrosis receptor Superfamily Member 6;
Species:  
Cynomolgus
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P86549
Synonyms: Fas; APT1; Fas1; TNFRSF6; Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen Fas; FasLG receptor; CD antigen CD95

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P70329
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Fas; Fas (TNF receptor Superfamily, Member 6); Prev. TNFRSF6; Apoptosis Signaling receptor Fas; Prev. APT1; Apo-1 Antigen; Prev. Fas1; CD95 Antigen; Tumor Necrosis Factor receptor Superfamily Member 6; Mutant Tumor Necrosis receptor Superfamily Member 6;
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P70330
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Fas; Fas (TNF receptor Superfamily, Member 6); Prev. TNFRSF6; Apoptosis Signaling receptor Fas; Prev. APT1; Apo-1 Antigen; Prev. Fas1; CD95 Antigen; Tumor Necrosis Factor receptor Superfamily Member 6; Mutant Tumor Necrosis receptor Superfamily Member 6;
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P73049
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Fas; Fas (TNF receptor Superfamily, Member 6); Prev. TNFRSF6; Apoptosis Signaling receptor Fas; Prev. APT1; Apo-1 Antigen; Prev. Fas1; CD95 Antigen; Tumor Necrosis Factor receptor Superfamily Member 6; Mutant Tumor Necrosis receptor Superfamily Member 6;
Species:  
Rat
Source:  
HEK293
loading...
    loading...