113 Results for "

GH

" in MedChemExpress (MCE) Product Catalog:
Products (113)

113 Results for "GH" in MCE Product Catalog:

21
21 Publications Verification
Cat. No.: HY-13913
CAS No.: 123653-11-2
Purity:  99.71%
Target:  

COX

Research Areas:  

Inflammation/Immunology Cancer

NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
loading...
    loading...
11
11 Cited Publications
Cat. No.: HY-14734
CAS No.: 249921-19-5
Purity:  99.94%
Synonyms: RC-1291; ONO-7643
Target:  

GHSR

Research Areas:  

Endocrinology Cancer

Anamorelin (RC-1291) is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin can be used in the research of anorexia and cancer cachexia .
loading...
    loading...
11
11 Cited Publications
Cat. No.: HY-14734A
CAS No.: 861998-00-7
Purity:  99.59%
Synonyms: RC-1291 hydrochloride; ONO-7643 hydrochloride
Target:  

GHSR

Research Areas:  

Endocrinology Cancer

Anamorelin (RC-1291) hydrochloride is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin hydrochloride can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin hydrochloride can be used in the research of anorexia and cancer cachexia .
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-16381
CAS No.: 396091-73-9
Synonyms: SOM230
Target:  

Somatostatin Receptor

Research Areas:  

Endocrinology Cancer

Pasireotide (SOM230), a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide also exhibits antisecretory, antiproliferative, and proapoptotic activity .
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-101422
CAS No.: 1380341-99-0
Purity:  99.93%
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology

GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-50844
CAS No.: 159752-10-0
Synonyms: MK-677; MK-0677
Target:  

GHSR

Research Areas:  

Endocrinology

Ibutamoren Mesylate (MK-677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. Ibutamoren Mesylate is an orally active growth hormone (GH) secretagogue.
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P80091
Synonyms: PTGS2; COX 2; COX2; COX-2; Cyclooxygenase; Cyclooxygenase2; Cyclooxygenase-2; hCox 2; PGG/HS; PGH synthase 2; PGHS 2; PGHS2; PHS 2; PHS II; PHS2 ; Prostaglandin endoperoxide synthase 2; Prostaglandin G/H synthase 2 precursor; Prostaglandin G/H synthase and cyclooxygenase; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; TIS10II; PGH2_HUMAN.

Host:  

Rabbit

Application:  

WB, ICC/IF, IHC-P

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-N1939
CAS No.: 56725-99-6
Synonyms: Icarisid I
Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P80090
Synonyms: COX2, PTGS2, Prostaglandin G/H synthase 2, Cyclooxygenase-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, COX-2, PGH synthase 2, PGHS-2

Host:  

Mouse

Application:  

WB, IHC-P, FC

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-16381A
CAS No.: 396091-76-2
Synonyms: SOM230 acetate
Target:  

Somatostatin Receptor

Research Areas:  

Endocrinology Cancer

Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P70261
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rMuSomatotropin/GH; Somatotropin; Growth Hormone; GH1; GH
Species:  
Source:  
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P74222
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Prostaglandin G/H synthase 2; COX-2; PGHS-2
Species:  
Source:  
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P5645
CAS No.: 1683582-94-6
Synonyms: Human liver expressed antimicrobial peptide-2
LEAP-2 (Human liver expressed antimicrobial peptide-2) is a GHS-R1a antagonist, with an IC50 of 6.0 nM. LEAP-2 suppresses the orexigenic effect of ghrelin. LEAP-2 attenuates ghrelin-induced growth hormone (GH) release and reduces basal food intake. LEAP-2 exhibits antimicrobial activity against microbial model organisms. LEAP-2 can be used for the study of obesity and infection .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P1155
CAS No.: 91826-20-9
Synonyms: rGHRH(1-29)NH2
Target:  

GHSR

Research Areas:  

Cancer

GRF (1-29) amide (rat) is a synthetic peptide which can stimulate the growth hormone (GH) secretion.
loading...
    loading...
Cat. No.: HY-14820A
CAS No.: 945212-59-9
Purity:  98.96%
Synonyms: EP-1572 acetate; AEZS-130 acetate
Target:  

GHSR

Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS) .
loading...
    loading...
Cat. No.: HY-108905
CAS No.: 68562-41-4
Synonyms: Human IGF-I; FK 780
Target:  

IGF-1R

Research Areas:  

Metabolic Disease

Mecasermin (Human IGF-I; FK 780) is a recombinant human insulin-like growth factor I (IGF-I). Mecasermin has the potential for the study of the growth failure of growth hormone (GH) insensitivity caused by GH receptor defects or GH-inhibiting antibodies .
loading...
    loading...
Cat. No.: HY-139431
CAS No.: 179030-22-9
Purity:  98.08%
Target:  

OGA Bacterial

Research Areas:  

Infection

NAG-thiazoline is a O-GlcNAcase inhibitor with a Ki of 180 nM. NAG-thiazoline is a potent GH20 GlcNAcase (VhGlcNAcase) inhibitor with an IC50 of 11.9 μM and a Ki of 62 µM .
loading...
    loading...
Cat. No.: HY-P2866
CAS No.: 9012-33-3
β-N-Acetylhexosaminidase, Streptococcus pneumoniae is a cell surface virulence factor of Streptococcus pneumoniae, which contains two synergistically acting GH20 domains (with higher activity in GH20-2). β-N-Acetylhexosaminidase, Streptococcus pneumoniae specifically recognizes and hydrolyzes substrates with β(1,2) glycosidic bonds via Trp-443 and Tyr-482 residues. β-N-Acetylhexosaminidase, Streptococcus pneumoniae catalyzes the hydrolysis of β(1,2)-linked N-acetylglucosamine groups and related disaccharides, and promotes persistent colonization of bacteria in the airway by modifying host defense molecules and releasing monosaccharides for bacterial growth. β-N-Acetylhexosaminidase, Streptococcus pneumoniae can be used in studies related to Streptococcus pneumoniae infection, acute pneumonia, otitis media and meningitis .
loading...
    loading...
Cat. No.: HY-P2869A
CAS No.: 9031-11-2
Target:  

Glycosidase

Research Areas:  

Metabolic Disease

β1-3 Galactosidase is a GH42 exoglycosidase that specifically hydrolyzes terminal β1-3-linked galactose. β1-3 Galactosidase uses Glu164 as the acid/base catalyst and Glu324 as the catalytic nucleophile to hydrolyze β1-3 galactosidic linkages. β1-3 Galactosidase can be used for research on galactoside metabolism .
loading...
    loading...
Cat. No.: HY-D1599
CAS No.: 932013-08-6
Synonyms: R6GH
Rhodamine 6G hydrazide (R6GH) is a fluorescent dye. Rhodamine 6G hydrazide can be used in selective colorimetric and fluorescent sensing .
loading...
    loading...