1380341-99-0
1380341-99-0
Chemical Structure
GAL-021
- CAS. Nr.: 1380341-99-0
- Formula:C11H22N6O
- Molecular Weight:254.33
IUPAC Name: 6-(methoxy(methyl)amino)-N2,N4-dipropyl-1,3,5-triazine-2,4-diamine
InChIKey: FJNLCHNQVJVCPY-UHFFFAOYSA-N
SMILES: CCCNC1=NC(N(OC)C)=NC(NCCC)=N1
Biological Activity: GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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GAL-021 | 99.93% | GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates. | ||||||||||||||||||||
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GAL-021 (Standard) | ≥98% | GAL-021 (Standard) is the analytical standard of GAL-021 (HY-101422). This product is intended for research and analytical applications. GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates. | ||||||||||||||||||||
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References
- [1]. Golder FJ, et al. Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator. Anesthesiology. 2015 Nov;123(5):1093-104. [Content Brief]
- [2]. J F McLeod, et al. GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers. Br J Anaesth. 2014 Nov;113(5):875-83. [Content Brief]
