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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
GM3
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "GM3" in MCE Product Catalog:
2
2 Cited Publications
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Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .
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D-threo-PDMP hydrochloride is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids (such as GM3 and GD3) on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth. D-threo-PDMP hydrochloride inhibits the synthesis of GM3, thereby reducing the adhesion ability of B16 melanoma cells and mimicking the pathological effects of hyperglycemia/TGF-β1. D-threo-PDMP hydrochloride inhibits the synthesis of GD3, thereby protecting liver cells from apoptosis induced by TNF-α. D-threo-PDMP hydrochloride can be used to study diseases related to targeted glycosphingolipid metabolism [3] .
Cat. No.: HY-116392E
CAS No.: 109836-82-0
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D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids (such as GM3 and GD3) on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth. D-threo-PDMP inhibits the synthesis of GM3, thereby reducing the adhesion ability of B16 melanoma cells and mimicking the pathological effects of hyperglycemia/TGF-β1. D-threo-PDMP inhibits the synthesis of GD3, thereby protecting liver cells from apoptosis induced by TNF-α. D-threo-PDMP can be used to study diseases related to targeted glycosphingolipid metabolism [3] .
Cat. No.: HY-171443
CAS No.: 94458-63-6
Synonyms: Lyso-GM3
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Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analogue of Ganglioside GM3 (HY-114456) with antitumor activities. Lyso-Monosialoganglioside inhibits EGF-induced increases in EGFR kinase activity in A431 epithelial cancer cells .
Cat. No.: HY-W342441
CAS No.: 54827-14-4
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Monosialoganglioside GM3 (bovine) is a monosialoganglioside and an inhibitor of VEGFR2 and Akt. At a concentration of 20 μM, Monosialoganglioside GM3 inhibits angiogenesis and reduces the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by inhibiting VEGFR2 and Akt phosphorylation. Ganglioside GM3 also inhibits ferroptosis, providing protective effects during the formation of abdominal aortic aneurysms. Additionally, Monosialoganglioside GM3 (bovine) acts as an inhibitor of insulin signaling, inducing the dissociation of the insulin receptor (IR)-Caveolin-1 complex from lipid microdomains and causing insulin resistance in adipocytes. Monosialoganglioside GM3 (bovine) can be used in cancer and metabolic disease research .
Cat. No.: HY-165160
CAS No.: 69345-49-9
Synonyms: GM3-Neugc ammonium; NeuGc-GM3 ammonium
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N-Glycolyl-ganglioside GM3 ammonium is a biochemical reagent.
Cat. No.: HY-173643
Synonyms: Biotin-C6:0-GM3 ammonium; N-Hexanoyl-biotin-monosialoganglioside GM3 ammonium
Cat. No.: HY-114456AS
CAS No.: 2260669-91-6
Cat. No.: HY-W127324
CAS No.: 1046791-63-2
Synonyms: NeuAcα(2-3)Galβ(1-4)Glc-ceramide (phyto-type)
Cat. No.: HY-N15822
CAS No.: 851608-39-4
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Cat. No.: HY-179778
CAS No.: 2260795-48-8
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C11-BODIPY 505/515 GM3 ammonium is a C11-BODIPY 505/515-labeled GM3 ammonium that can be used to prepare lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).
Cat. No.: HY-114456S
Cat. No.: HY-152002S
CAS No.: 2692623-85-9
Cat. No.: HY-N15844
CAS No.: 1408313-38-1
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Cat. No.: HY-165665S
Cat. No.: HY-112488
CAS No.: 1239893-96-9
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EXEL-0346 is an orally active glucosylceramide synthase (GCS) inhibitor, with an IC50 of 2 nM. EXEL-0346 combined with insulin increases pAkt. EXEL-0346 effectively reduces the levels of Glucosylceramide, Lactosylceramide and GM3. EXEL-0346 improves obesity and diabetes .
Cat. No.: HY-131701
CAS No.: 109785-20-8
Synonyms: C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine; Lyso-Lactosylceramide (synthetic)
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Lactosyl-C18-sphingosine (C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine) is a bioactive sphingolipid that is a form of lactosylceramide but lacks the fatty acyl group. Lysolactosylceramide (1-50 μM) reduces the viability of human neutrophils in a concentration-dependent manner. Unlike lactosylceramide, Lactosyl-C18-sphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes. Lactosyl-C18-sphingosine is a lysoganglioside GM3.
Cat. No.: HY-E70049
CAS No.: 67338-98-1
Synonyms: GM2/GD2 synthase
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beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) (GM2/GD2 synthase) is a key enzyme which catalyzes the conversion of GM3, GD3 and lactosylceramide (LacCer) to GM2, GD2 and asialo-GM2 (GA2), respectively. beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) is a key enzyme to control the synthesis of brain-enriched complex gangliosides .
Cat. No.: HY-N15906
CAS No.: 94458-61-4
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Cat. No.: HY-RS05835
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Grm6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grm6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
