1239893-96-9
Chemical Structure
EXEL-0346
- CAS No.: 1239893-96-9
- Formula:C27H29BrF3N3O3
- Molecular Weight:580.44
IUPAC Name: N-((2S)-1-(3-amino-8-azabicyclo[3.2.1]octan-8-yl)-3-(4-bromophenyl)-1-oxopropan-2-yl)-1-(4-(trifluoromethoxy)phenyl)cyclopropane-1-carboxamide
InChIKey: TUDINUHHPSENND-FTKYIGPGSA-N
SMILES: O=C(C1(C2=CC=C(OC(F)(F)F)C=C2)CC1)N[C@@H](CC3=CC=C(Br)C=C3)C(N4C5CC(N)CC4CC5)=O
Biological Activity: EXEL-0346 is an orally active glucosylceramide synthase (GCS) inhibitor, with an IC50 of 2 nM. EXEL-0346 combined with insulin increases pAkt. EXEL-0346 effectively reduces the levels of Glucosylceramide, Lactosylceramide and GM3. EXEL-0346 improves obesity and diabetes[1].
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EXEL-0346 | EXEL-0346 is an orally active glucosylceramide synthase (GCS) inhibitor, with an IC50 of 2 nM. EXEL-0346 combined with insulin increases pAkt. EXEL-0346 effectively reduces the levels of Glucosylceramide, Lactosylceramide and GM3. EXEL-0346 improves obesity and diabetes. | |||||||||||||||||||||
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