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HEp-2 cell

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30

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4

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5

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N6771
    Cyclopiazonic acid
    5+ Cited Publications

    		 Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV Infection
    Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B [1][4][5].
    Cyclopiazonic acid
  • HY-D0203
    Basic green 4

    Malachite green

    		 Environmental Pollutants Fluorescent Dye Others
    Basic green 4 (Malachite green) is a cationic dye that is widely used as a bactericide in aquaculture and is also commonly used in laboratories for the determination of phosphates. Basic green 4 exhibits high cytotoxicity and carcinogenicity to mammalian cells, specifically shown by its IC50 values of 2.03 µM for HEp-2 human laryngeal cells and 13.8 µM for Caco-2 human colorectal adenocarcinoma cells, and it can promote the development of liver tumors. The maximum absorbance wavelength is 621 nm .
    Basic green 4
  • HY-P99804
    Clesrovimab
    3 Publications Verification

    MK1654

    		 RSV Infection
    Clesrovimab (MK1654) is a humanized IgG1 monoclonal antibody targeting the respiratory syncytial virus (RSV) protein F. Clesrovimab binds to pre-fusion and post-fusion forms of RSV-A fusion protein with high affinity, with corresponding KD values of 71 pM and 480 pM, respectively. Clesrovimab is applicable for the research of RSV infection .
    Clesrovimab
  • HY-134978
    (Rac)-SHIN2
    2 Publications Verification

    		 SHMT Bacterial Others
    (Rac)-SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac)-SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac)-SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus .
    (Rac)-SHIN2
  • HY-D2769
    Oregon green 488 azide

    Difluorocarboxyfluorescein azide, 6-isomer

    		 Fluorescent Dye Others
    Oregon green 488 azide (Difluorocarboxyfluorescein azide, 6-isomer) is a bright green fluorescent azide-activated probe that reacts with terminal alkynes via copper-catalyzed azide-alkyne cycloaddition (CuAAC). Oregon green 488 azide can label goat anti-mouse IgG and exhibits excellent luminescence efficiency. Oregon green 488 azide, as a streptavidin conjugate, is used for flow cytometry staining of macrophages .
    Oregon green 488 azide
  • HY-D0300
    Leucomalachite green
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    Leucomalachite green is the major reduced metabolite of malachite green (MG) and has lower cytotoxicity (such as HEp-2 and Caco-2) than malachite green. Leucomalachite green may be involved in interfering with cell metabolism or redox balance and can be used to evaluate its potential harm to human cells as a food contaminant .
    Leucomalachite green
  • HY-W008864
    Lactose octaacetate

    β-Octaacetyllactose

    		 Fungal Infection
    Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1 .
    Lactose octaacetate
  • HY-N7803
    De-O-Methyllasiodiplodin

    		Apoptosis Cancer
    De-O-Methyllasiodiplodin, a cytotoxic compound, can be isolated from Ludwigia hyssopifolia. De-O-Methyllasiodiplodin inhibits Hep-2 cell growth by inducing apoptosis .
    De-O-Methyllasiodiplodin
  • HY-121561
    Nitrocaphane

    At-1258; Nsc 245413

    		 DNA/RNA Synthesis Cancer
    Nitrocaphane (At-1258) is an antineoplastic agent whose target of action is DNA. Nitrocaphane has a broad antineoplastic spectrum. Nitrocaphane's cytotoxicity on HEp-2 cells can be enhanced by hyperthermia. Nitrocaphane can be used in the research of tumors such as malignant trophoblastic tumors .
    Nitrocaphane
  • HY-178151
    CGR-50

    		RSV Infection
    CGR-50 is a potent RSV fusion glycoprotein (F protein) inhibitor (EC50 = 32.6 nM against RSV A2 in HEp-2 cells). CGR-50 blocks RSV entry by binding to the F protein and inhibiting membrane fusion. CGR-50 can be used for RSV infection research .
    CGR-50
  • HY-W075353
    TPPS

    		Fluorescent Dye MOFs Cancer
    TPPS can be used as a non-cytotoxic probe for detecting tumor location .
    TPPS
  • HY-N10850
    Blepharotriol

    		Bacterial Cancer
    Blepharotriol is a phenolic triterpene that can be found in Maytenus blepharodes. Blepharotriol shows antimicrobial activity with a MIC value of 8-4 µg/ml for Bacillus subtilis. Blepharotriol shows cytotoxic activity with IC50s of 12.2, >20, >20 µM for HeLa, Hep-2, Vero cells, respectively .
    Blepharotriol
  • HY-D0300S1
    Leucomalachite green-d6

    		Isotope-Labeled Compounds Biochemical Assay Reagents Others
    Leucomalachite green-d6 is the deuterated derivative of Leucomalachite green (HY-D0300). Leucomalachite green is the major reduced metabolite of malachite green (MG) and has lower cytotoxicity (such as HEp-2 and Caco-2) than malachite green. Leucomalachite green may be involved in interfering with cell metabolism or redox balance and can be used to evaluate its potential harm to human cells as a food contaminant .
    Leucomalachite green-d6
  • HY-P991370
    SBT-100 (His Tag)

    		STAT Cancer
    SBT-100 (His Tag) is a human monoclonal antibody (mAb) targeting STAT3. SBT-100 (His Tag) inhibits IL-6-mediated P-STAT3 nuclear translocation in HEp-2 and PANC-1 cells. SBT-100 (His Tag) has tumor growth inhibitory effects on MDA-MB-231 .
    SBT-100 (His Tag)
  • HY-N2802
    Euptox A

    9-Oxo-10,11-dehydroageraphorone

    		 Apoptosis Caspase Parasite Infection Cancer
    Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells .
    Euptox A
  • HY-D0300S
    Leucomalachite green-d5

    		Isotope-Labeled Compounds Biochemical Assay Reagents Others
    Leucomalachite green-d5 is the deuterated derivative of Leucomalachite green (HY-D0300). Leucomalachite green is the major reduced metabolite of malachite green (MG) and has lower cytotoxicity (such as HEp-2 and Caco-2) than malachite green. Leucomalachite green may be involved in interfering with cell metabolism or redox balance and can be used to evaluate its potential harm to human cells as a food contaminant .
    Leucomalachite green-d5
  • HY-D0300R
    Leucomalachite green (Standard)

    		Biochemical Assay Reagents Reference Standards Others
    Leucomalachite green (Standard) is the analytical standard of Leucomalachite green (HY-D0300). This product is intended for research and analytical applications. Leucomalachite green is the major reduced metabolite of malachite green (MG) and has lower cytotoxicity (such as HEp-2 and Caco-2) than malachite green. Leucomalachite green may be involved in interfering with cell metabolism or redox balance and can be used to evaluate its potential harm to human cells as a food contaminant .
    Leucomalachite green (Standard)
  • HY-149632
    EGFR/HER2/DHFR-IN-2

    		EGFR Dihydrofolate reductase (DHFR) Cancer
    EGFR/HER2/DHFR-IN-2 (Compound 4b) is an inhibitor of EGFR, HER2, and DHFR (IC50: 0.248, 0.156, 0.138 μM respectively). EGFR/HER2/DHFR-IN-2 has anticancer activities against a panel of cancer cells (IC50: 9.14, 7.33, 14.18, 24.87, 20.07, 6.16 μM for Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7 cells). EGFR/HER2/DHFR-IN-2 reduce breast cancer tumor growth .
    EGFR/HER2/DHFR-IN-2
  • HY-N6771R
    Cyclopiazonic acid (Standard)

    		Reference Standards Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV Infection
    Ancitabine (hydrochloride) (Standard) is the analytical standard of Ancitabine (hydrochloride). This product is intended for research and analytical applications. 0
    Cyclopiazonic acid (Standard)
  • HY-154966
    RSV L-protein-IN-3

    		RSV Infection
    RSV L-protein-IN-3 is a wild-type RSV polymerase inhibitor with an IC50 value of 10.4 μM and an EC50 value of 2.1 μM (against RSV). RSV L-protein-IN-3 has lesser cytotoxicity than the clinical agent, Ribavirin (HY-B0434) .
    RSV L-protein-IN-3
  • HY-168889
    HRSV/hCoV-229E-IN-1

    		RSV SARS-CoV Infection
    HRSV/hCoV-229E-IN-1 (compound 8X) is a potent HRSV and hCoV-229E inhibitor with an IC50 value of 2.1 µM for hCoV-229E. HRSV/hCoV-229E-IN-1 inhibits cell viability .
    HRSV/hCoV-229E-IN-1
  • HY-162701
    Antiviral agent 58

    		SARS-CoV Influenza Virus RSV HSV Infection
    Antiviral agent 58 (Compound J1) is an orally active antiviral agent with broad-spectrum antiviral activity against enveloped viruses, including influenza A virus (IAV), respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human coronavirus OC43 (HCoV-OC43), herpes simplex virus type 1 (HSV-1), and HSV-2 .
    Antiviral agent 58
  • HY-168729
    Antibacterial agent 256

    		Bacterial Infection
    Antibacterial agent 256 (Compound C09) is an inhibitor for type I signal peptidase (SPase I). Antibacterial agent 256 inhibits gram-positive bacteria, that inhibits S. aureus ATCC 29213, E. faecium QF31, E. faecalis SF23-1 and S. suis P1/7, with MIC of 1-16 μg/mL. Antibacterial agent 256 exhibits cytotoxicity in cancer cell HEp-2 and Caco-2 with CC50 of 14.65 μg/mL and 21.93 μg/mL. Antibacterial agent 256 exhibits a hemolytic activity on mouse RBCs, with an HC50 of 13.29 μg/mL. Antibacterial agent 256 ameliorates the MRSA skin infection in mouse model .
    Antibacterial agent 256
  • HY-181603
    Antiviral agent 79

    		Enterovirus IFNAR Infection
    Antiviral agent 79 is a broad-spectrum antiviral agent. Antiviral agent 79 exhibits anti-EV71, anti-CVB3 and anti-ADV7 activities. Antiviral agent 79 activates the host type I interferon signaling pathway to enhance antiviral defense. Antiviral agent 79 can be used in research related to viral infections .
    Antiviral agent 79
  • HY-181864
    Rac1-IN-6

    		Parasite Infection
    Rac1-IN-6 (Compound 5e) is a selective Rac1 inhibitor and antimalarial agent. Rac1-IN-6 inhibits Rac1 activation induced by the Escherichia coli CNF1 toxin. Rac1-IN-6 suppresses the growth of chloroquine-sensitive Plasmodium falciparum D10 (IC50 = 76.0 nM) and chloroquine-resistant Plasmodium falciparum W2 (IC50 = 236.6 nM) .
    Rac1-IN-6
  • HY-N19297
    Endosidin1

    Prieurianin

    		 Elastase Inflammation/Immunology Cancer
    Endosidin1 (Prieurianin) is a Prieurianin with cleaved A and B rings. Endosidin1 is isolated from the roots of Aphanamixis polystachya. Endosidin1 inhibits superoxide anion production and Elastase release in neutrophils, with an IC50 >10 μg/mL. Endosidin1 exhibits mild cytotoxic activity against laryngeal cancer cells in vitro. Endosidin1 shows anti-inflammatory activity. Endosidin1 can be used in studies related to laryngeal cancer .\n
    Endosidin1
  • HY-182030
    RSV fusion protein IN-1

    		RSV Infection
    RSV fusion protein IN-1 is an orally active RSV pre-fusion F protein inhibitor with an IC50 of 0.10 nM against RSV. RSV fusion protein IN-1 forms stable hydrogen bonds and π-π stacking interactions with pre-fusion F protein to block viral fusion and entry. RSV fusion protein IN-1 suppresses RSV F protein expression in epithelial cells. RSV fusion protein IN-1 reduces viral burden in the lungs of RSV-infected murine models.RSV fusion protein IN-1 can be used for the research of respiratory syncytial virus (RSV) infection .
    RSV fusion protein IN-1
  • HY-P992301
    Anti-RSV F Antibody (R4.C6)

    		RSV Infection
    Anti-RSV F Antibody (R4.C6) is a monoclonal antibody against RSV F, with a Kd of 0.34 nM for the post-fusion RSV F trimer. Anti-RSV F Antibody (R4.C6) recognizes a unique neutralizing epitope spanning epitopes II and IV on both pre-fusion and post-fusion RSV F. Anti-RSV F Antibody (R4.C6) can be used in studies related to respiratory syncytial virus infection .
    Anti-RSV F Antibody (R4.C6)
  • HY-P992423
    NIAID RSVF2-5

    		RSV Infection
    NIAID RSVF2-5 is a human monoclonal antibody fragment. NIAID RSVF2-5 binds to conserved, distinct conformational epitopes on RSV fusion glycoprotein, and shows activity against RSV subgroup A and B strains. NIAID RSVF2-5 reduces pulmonary and lung viral titers in RSV-infected rodents. NIAID RSVF2-5 can be used for the research of respiratory syncytial virus infection .
    NIAID RSVF2-5
  • HY-P992175
    ADI-14448

    		RSV Infection
    ADI-14448 is a RSV prefusion fusion glycoprotein inhibitor and HMPV fusion glycoprotein inhibitor, with a Kd of 3.8 × 10 -10 M for RSV preF. ADI-14448 binds to epitope III of RSV preF, thereby blocking viral infection. ADI-14448 neutralizes RSV subtype A and HMPV subtype A1. ADI-14448 can be used in studies related to respiratory syncytial virus infection and metapneumovirus infection .
    ADI-14448

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