54940-95-3
54940-95-3
Chemical Structure
Nitrocaphane
Synonym(s): At-1258; Nsc 245413
- CAS No.: 54940-95-3
- Formula:C14H19Cl2N3O4
- Molecular Weight:364.22
IUPAC Name: 2-amino-3-(2-((bis(2-chloroethyl)amino)methyl)-5-nitrophenyl)propanoic acid
InChIKey: VEBTZMUIBMIPCD-UHFFFAOYSA-N
SMILES: NC(C(O)=O)CC1=CC([N+]([O-])=O)=CC=C1CN(CCCl)CCCl
Biological Activity: Nitrocaphane (At-1258) is an antineoplastic agent whose target of action is DNA. Nitrocaphane has a broad antineoplastic spectrum. Nitrocaphane's cytotoxicity on HEp-2 cells can be enhanced by hyperthermia. Nitrocaphane can be used in the research of tumors such as malignant trophoblastic tumors[1][2].
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Nitrocaphane | Nitrocaphane (At-1258) is an antineoplastic agent whose target of action is DNA. Nitrocaphane has a broad antineoplastic spectrum. Nitrocaphane's cytotoxicity on HEp-2 cells can be enhanced by hyperthermia. Nitrocaphane can be used in the research of tumors such as malignant trophoblastic tumors. | |||||||||||||||||||||
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References
- [1]. Li LG, et al. Enhancement of nitrocaphane cytotoxicity by hyperthermia in vitro. Int J Hyperthermia. 1989 Jul-Aug;5(4):525-33. [Content Brief]
- [2]. Wang YE. [Combined treatment of malignant trophoblastic tumor with 5-fluorouracil and nitrocaphane]. Zhonghua Yi Xue Za Zhi. 1988 Dec;68(12):696-8. [Content Brief]
