5 Results for "

Isolinderalactone

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "Isolinderalactone" in MCE Product Catalog:

1
Isolinderalactone
Isolinderalactone
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1 Cited Publications
Cat. No.: HY-N3001
CAS No.: 957-66-4
Category:  

Terpenoids Sesquiterpenes Plants Lauraceae Disease Research Fields Lindera aggregata (Sims) Kosterm. Cancer

Target:  

STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase

Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .
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Coibamide A
Coibamide A
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Cat. No.: HY-P3990
CAS No.: 1029227-48-2
Target:  

VEGFR Autophagy Apoptosis

Research Areas:  

Cancer

Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts .
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Telomycin
Telomycin
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Cat. No.: HY-P1720
CAS No.: 19246-24-3
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Telomycin is a calcium-dependent antibiotic, which can be produced by Streptomyces. Telomycin inhibits gram-positive bacteria, including multidrug-resistant (MDR) pathogens .
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Protactin
Protactin
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Cat. No.: HY-P1709
CAS No.: 141912-59-6
Category:  

Microorganisms Antibiotics Other Antibiotics

Target:  

Bacterial

Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .
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TL-119
TL-119
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Cat. No.: HY-P11022
CAS No.: 55599-68-3
Synonyms: A-3302-B
Target:  

Endogenous Metabolite HSV TRP Channel

Research Areas:  

Infection Cancer

TL-119 (A-3302-B) is a polypeptide. TL-119 can be isolated from the bacteria Micromonospora sp. MAG 9-7 and Saccharomonospora sp. CNQ-490. TL-119 inhibits TRPV-1. TL-119 exhibits antiviral activity against HSV-2. TL-119 possesses anticancer activity against gastric cancer and colorectal cancer .
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