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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
KIAA1363
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "KIAA1363" in MCE Product Catalog:
3
3 Cited Publications
Research Areas:
LY2183240 is a highly potent blocker of anandamide uptake (IC50= 270 pM; Ki=540 nM). LY2183240 is a potent, covalent inhibitor of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) with an IC50 of 12.4 nM. LY2183240 inactivates FAAH by carbamylation of the enzyme's serine nucleophile. LY2183240 also inhibits several other brain serine hydrolases with IC50s of 5.3, 0.09, 8.2 nM for MAG lipase, bh6 and KIAA1363, respectively .
Target:
Research Areas:
JW480 is a selective KIAA1363/AADACL1 inhibitor with oral activity, featuring IC50 values of 12 nM against human KIAA1363, 20 nM against mouse KIAA1363. JW480 blocks lipid deacetylase activity to restrain HAG metabolism and lowers retinyl ester hydrolase function in hepatic stellate cells. JW480 reduces MAGE lipid levels and inhibits migration, invasion, survival and tumor growth of prostate cancer cells. JW480 lowers PKCδ phosphorylation, facilitates HAGP accumulation, diminishes platelet aggregation, dense granule secretion and Ca 2+ flux, delays arterial thrombosis and prolongs tail bleeding time in rats. JW480 can be used for the study of prostate cancer and thrombosis .
Cat. No.: HY-165025
CAS No.: 112014-15-0
Cat. No.: HY-107582R
CAS No.: 1354359-53-7
Research Areas:
JW480 (Standard) is the analytical standard of JW480 (HY-107582). This product is intended for research and analytical applications. JW480 is a potent and selective inhibitor of a serine hydrolase enzyme KiAA1363 .
Cat. No.: HY-P705933
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NCEH1; NCEH; Prev. AADACL1; Alkylacetylglycerol Acetylhydrolase; Acetylalkylglycerol Acetylhydrolase; 2-Acetyl MAGE Hydrolase; Arylacetamide Deacetylase-Like 1; Neutral Cholesterol Ester Hydrolase 1; KIAA1363
Species:
Human
Source:
E. coli
Cat. No.: HY-10865R
CAS No.: 874902-19-9
Target:
Research Areas:
LY2183240 (Standard) is the analytical standard of LY2183240 (HY-10865). This product is intended for research and analytical applications. LY2183240 is a highly potent blocker of anandamide uptake (IC50= 270 pM; Ki=540 nM). LY2183240 is a potent, covalent inhibitor of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) with an IC50 of 12.4 nM. LY2183240 inactivates FAAH by carbamylation of the enzyme's serine nucleophile. LY2183240 also inhibits several other brain serine hydrolases with IC50s of 5.3, 0.09, 8.2 nM for MAG lipase, bh6 and KiAA1363, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
