926657-43-4
926657-43-4
Chemical Structure
AS115
- CAS No.: 926657-43-4
- Formula:C21H32FNO4
- Molecular Weight:381.48
IUPAC Name: 2-fluorophenyl (2-(((1R,2S)-2-(butoxymethyl)cyclohexyl)methoxy)ethyl)carbamate
InChIKey: BTYYXSHZANWPEB-MSOLQXFVSA-N
SMILES: FC(C=CC=C1)=C1OC(NCCOC[C@H]2[C@H](CCCC2)COCCCC)=O
Biological Activity: AS115 is a potent and selective KIAA1363 inactivator with IC50 value of 150 nM. KIAA1363 is a 2-acetyl monoacylglycerol ether (MAGE) hydrolase that is upregulated in aggressive cancers of various tissues[1][2].
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AS115 | AS115 is a potent and selective KIAA1363 inactivator with IC50 value of 150 nM. KIAA1363 is a 2-acetyl monoacylglycerol ether (MAGE) hydrolase that is upregulated in aggressive cancers of various tissues. | |||||||||||||||||||||
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References
- [1]. Chiang KP, et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol. 2006 Oct;13(10):1041-50. [Content Brief]
- [2]. Jessani N, et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10335-40. [Content Brief]
Keywords
