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Isoforms Recommended:	Kinesin-5/Eg5/KSP

Results for "

KSP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) Apoptosis (10) Bacterial (1) Beta-lactamase (1) Drug Derivative (1) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (1) Kinesin (24) Lipoxygenase (1) Mitosis (2) PI3K (1) PROTACs (1) Reference Standards (1) VEGFR (1)
By Research Areas:	Cancer (27) Infection (1) Neurological Disease (1)
Oligonucleotides:	siRNA drugs (3) siRNAs (3)

Inhibitors & Agonists

MCE Kits

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15187

Filanesib Maximum Cited Publications 7 Publications Verification ARRY-520	Kinesin Apoptosis	Cancer
Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .

HY-50759

Ispinesib Maximum Cited Publications 7 Publications Verification SB-715992; CK-0238273	Kinesin Apoptosis	Cancer
Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

HY-12069

SB-743921 hydrochloride 5 Publications Verification	Kinesin	Cancer
SB-743921 hydrochloride is a potent inhibitor of the mitotic *kinesin KSP* (Eg5), with a K_i** of 0.1 nM.

HY-50672

MK-0731	Kinesin Apoptosis Lipoxygenase	Cancer
MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 2.2 nM and a pK_a of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy .

HY-13224

AZD4877	Kinesin Apoptosis Mitosis	Cancer
AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC₅₀ of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity .

HY-149416

Mal-PEG8-Val-Ala-PAB-SB-743921	Drug-Linker Conjugates for ADC	Cancer
Mal-PEG8-Val-Ala-PAB-SB-743921 (Compound D7) is a Drug-Linker Conjugates for ADC. Mal-PEG8-Val-Ala-PAB-SB-743921 consists of KSP inhibitor SB-743921 (HY-14661) and a linker. Mal-PEG8-Val-Ala-PAB-SB-743921 can be used for synthesis of ADCs .

HY-15187A

(R)-Filanesib (R)-ARRY-520	Kinesin	Cancer
(R)-Filanesib ((R)-ARRY-520) is the R-enantiomer of Filanesib (HY-15187). Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 6 nM.

HY-122247

PVZB1194	Kinesin	Cancer
PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC₅₀ of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC₅₀: 5.5 μM). PVZB1194 can be used in the study of tumors .

HY-14661

SB-743921 free base	Kinesin	Cancer
SB-743921 free base is a potent selective inhibitor of the mitotic *kinesin KSP* (Eg5), with a K_i** of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases .

HY-171112

KSP-1007	Beta-lactamase Bacterial	Infection
KSP-1007 is a bicyclic boronate-based broad-spectrum β-lactamase inhibitor. KSP-1007 can effectively inhibit class A, B, C and D β-lactamases, including serine-type, metallo-type (such as NDM, VIM, IMP) and Acinetobacter baumannii OXA-type enzymes. KSP-1007 can enhance the antibacterial activity of Meropenem (HY-13678), reduce its MIC value, and be effective against carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa. KSP-1007 can be used for the research of bacterial infection .

HY-124790

KSP-IA	Kinesin Mitosis	Cancer
KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC₅₀ value of 3.6 nM. KSP-IA inhibits cell mitosis .

HY-168727

KSP ligand 1	Kinesin	Cancer
KSP ligand 1 is a protein ligand that targets KSP (Kinesin), and it can be used to synthesize PROTAC KSP-IN-1 (HY-168725) for cancer research .

HY-168725

*PROTAC KSP* degrader 1**	PROTACs Kinesin Apoptosis	Cancer
PROTAC KSP degrader 1 (Compound 21) is a PROTAC Degrader for kinesin spindle protein (KSP), that degrades *KSP* in HCT-116 with DC₅₀ of 114.8 nM. PROTAC KSP degrader 1 inhibits the proliferation of HCT-116 with IC₅₀ of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP degrader 1 exhibits antitumor efficacy in mouse model . (Blue: Ligand for E3 Ligase Cereblon (HY-103596); Blank: Linker (HY-168726); Pink: Target Protein Ligand (HY-168727))

HY-177613A

ALN-12115 sodium AD12115 sodium	Kinesin	Cancer
ALN-12115 sodium is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.

HY-177613

ALN-12115 AD12115	Kinesin	Cancer
ALN-12115 is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.

HY-15187C

Filanesib hydrochloride Maximum Cited Publications 7 Publications Verification ARRY-520 hydrochloride	Kinesin Apoptosis	Neurological Disease Cancer
Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .

HY-157338

NHS-Ala-Ala-Asn-active metabolite	ADC Linker Kinesin	Cancer
NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .

HY-122130

SCH 2047069 MK-8267	Kinesin Apoptosis	Cancer
SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (K_d: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC₅₀ value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma .

HY-177614

ALN-3133 sodium AD3133 sodium	VEGFR	Cancer
ALN-3133 sodium is a siRNA that targets VEGF, and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for kinesin spindle protein (KSP) and VEGF with potential antitumor activity.

HY-10084

CK0106023	Kinesin	Cancer
CK0106023 is a potent and specific allosteric inhibitor of *KSP* with a K_i value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice .

HY-15187B

Filanesib TFA ARRY-520 TFA	Kinesin	Cancer
Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity .

HY-50759A

Ispinesib mesylate SB-715992 mesylate; CK-0238273 mesylate	Kinesin Apoptosis	Cancer
Ispinesib (SB-715992) mesylate is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

HY-162292

Anticancer agent 190	PI3K Kinesin	Cancer
Anticancer agent 190 (compound 3e) is an inhibitor targeting *KSP* (Kinesin) and PI3Kδ with activity against breast cancer .

HY-50759R

Ispinesib (Standard) SB-715992 (Standard); CK-0238273 (Standard)	Kinesin Apoptosis Reference Standards	Cancer
Ispinesib (Standard) is the analytical standard of Ispinesib. This product is intended for research and analytical applications. Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.

HY-50759S

Ispinesib-d5 SB-715992-d₅	Kinesin Apoptosis	Cancer
Ispinesib-d₅ (SB-715992-d₅) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP) .

HY-117440

4'-Methoxy-S-trityl-L-cysteinol	Kinesin	Cancer
4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4'-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 μM, showing stronger inhibitory potency than the parent molecule and monastrol.

HY-179355

KSP-IN-1	Kinesin	Cancer
KSP-IN-2 (compound 12) is a kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 450 nM .

HY-13224A

AZD4877 hydrochloride	Endogenous Metabolite	Cancer
AZD4877 hydrochloride is a synthetic dynein inhibitor with potential anti-tumor activity. AZD4877 selectively inhibits the microtubule dynein KSP (also known as kinesin-5 or Eg5), which may lead to inhibition of mitotic spindle assembly. The action of AZD4877 may activate the spindle assembly checkpoint, leading to cell cycle arrest at the mitotic stage. AZD4877 may induce cell death in actively dividing tumor cells. AZD4877 may be less likely to cause peripheral neuropathy associated with microtubule-targeted compounds as it is not involved in post-mitotic processes. AZD4877 is essential for the formation of bipolar spindles and the proper segregation of sister chromosomes .

HY-W198426

1-([1,1'-Biphenyl]-4-yl)urea Biphenyl-4-ylurea; (4-Phenylphenyl)urea	Drug Derivative	Others
1-(-4-yl) urea (compound 44) is a biphenyl urea analog .

Cat. No.	Product Name

HY-KE7005

Bcl I
MCE Bcl I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Fba I, Ksp22 I.

HY-KE7034

Sac II
MCE Sac II is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Cfr42 I, Ksp I, Sfr303 I, SgrB I.

Species:	Human (3)
Tag:	His (3)
Source:	HEK293 (2) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73507

	CDH16 Protein, Human (HEK293, His) Cadherin-16; KSP-cadherin; CDH16	Human	HEK293
	CDH16, a calcium-dependent cell adhesion protein, belongs to the cadherin family. It exhibits homophilic interactions, potentially contributing to cell-type sorting and regulating cell-cell adhesions for cellular organization. CDH16 Protein, Human (HEK293, His) is the recombinant human-derived CDH16 protein, expressed by HEK293 , with N-His labeled tag.

HY-P73507A

	CDH16 Protein, Human (HEK293, C-His) Cadherin-16; KSP-cadherin; CDH16	Human	HEK293
	CDH16, a calcium-dependent cell adhesion protein, belongs to the cadherin family. It exhibits homophilic interactions, potentially contributing to cell-type sorting and regulating cell-cell adhesions for cellular organization. CDH16 Protein, Human (HEK293, C-His) is the recombinant human-derived CDH16 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77433

	FGFBP2 Protein, Human (sf9, His) Fibroblast growth factor-binding protein 2; KSP37; HBp17-RP	Human	Sf9 insect cells
	The FGFBP2 protein is secreted by cytotoxic T lymphocytes and binds reversibly to acidic and basic fibroblast growth factors. It also binds to the basement membrane glycans. FGFBP2 is highly expressed in human malignant cells and normal tissues and is a potential prognostic biomarker for tumors. FGFBP2 Protein, Human (sf9, His) is the recombinant human-derived FGFBP2 protein, expressed by Sf9 insect cells , with C-His labeled tag.

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Ispinesib-d5
Ispinesib-d₅ (SB-715992-d₅) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP) .

Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (2) Mouse (2) human (1)
Application:	IHC-P (2) ICC/IF (2) IF-Tissue (1) IP (2) WB (2) ELISA (2)
Isotype:	IgG (1) IgG1,IgG/Kappa (1) IgG2b (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810275

	KSP37 Antibody (YA9619)	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	KSP37 Antibody (YA9619) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KSP37.

HY-P81731

	Cadherin 16 Antibody (YA1476) CDH16; Cadherin-16; Kidney-specific cadherin; KSP-cadherin	WB, IHC-P, IP	Human, Mouse
	Cadherin 16 Antibody (YA1476) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cadherin 16.

HY-P85997

	Cadherin 16 Antibody (YA5689) Cadherin-16; Kidney-specific cadherin; KSP-cadherin; Kidney specific cadherin antibody	IHC-P, ICC/IF, ELISA	Human, Mouse
	Cadherin 16 Antibody (YA5689) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cadherin 16.

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Cat. No.	Product Name		Classification

HY-177613A

ALN-12115 sodium AD12115 sodium		siRNAs siRNA drugs
ALN-12115 sodium is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.

HY-177613

ALN-12115 AD12115		siRNAs siRNA drugs
ALN-12115 is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.

HY-177614

ALN-3133 sodium AD3133 sodium		siRNAs siRNA drugs
ALN-3133 sodium is a siRNA that targets VEGF, and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for kinesin spindle protein (KSP) and VEGF with potential antitumor activity.

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