133 Results for "

Keap1/Nrf2

" in MedChemExpress (MCE) Product Catalog:
Products (133)

133 Results for "Keap1/Nrf2" in MCE Product Catalog:

523
RSL3
RSL3
0 Images
523 Publications Verification
Cat. No.: HY-100218A
CAS No.: 1219810-16-8
Purity:  99.90%
Synonyms: (1S,3R)-RSL3
Target:  

p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)

Research Areas:  

Cancer

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells [1].
123
Curcumin
Curcumin
0 Images
123 Cited Publications
Cat. No.: HY-N0005
CAS No.: 458-37-7
Synonyms: Diferuloylmethane; Natural Yellow 3; Turmeric yellow
Category:  

Anti-aging Plants Food Research Sunscreen Pigments Phenols Polyphenols Cosmetic Research Curcuma longa Disease Research Fields Cancer Zingiberaceae

Target:  

Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis Apoptosis

Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
87
4-Octyl itaconate
4-Octyl itaconate
0 Images
87 Cited Publications
Cat. No.: HY-112675
CAS No.: 3133-16-2
Purity:  99.92%
Synonyms: 4-OI
Target:  

Keap1-Nrf2

Research Areas:  

Inflammation/Immunology

4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 [1].
71
Sulforaphane
Sulforaphane
0 Images
71 Cited Publications
Cat. No.: HY-13755
CAS No.: 4478-93-7
Purity:  98.87%
Category:  

Natural Products other families Plants Disease Research Fields Inflammation/Immunology

Target:  

HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS)

Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties [1] [2] .
41
Brusatol
Brusatol
0 Images
41 Cited Publications
Cat. No.: HY-19543
CAS No.: 14907-98-3
Synonyms: NSC 172924
Category:  

Simaroubaceae Terpenoids Diterpenoids Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.

Target:  

Keap1-Nrf2 Apoptosis

Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent [1]. Brusatol increases cellular apoptosis [2].
23
KI696
KI696
0 Images
23 Cited Publications
Cat. No.: HY-101140
CAS No.: 1799974-70-1
Purity:  98.67%
Target:  

Keap1-Nrf2

Research Areas:  

Metabolic Disease Inflammation/Immunology

KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction [1].
11
ML334
ML334
0 Images
11 Cited Publications
Cat. No.: HY-110258
CAS No.: 1432500-66-7
Purity:  ≥99.0%
Synonyms: LH601A
Target:  

Quinone Reductase Keap1-Nrf2

Research Areas:  

Cancer

ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity [1] [2].
6
Rutaecarpine
Rutaecarpine
0 Images
6 Cited Publications
Cat. No.: HY-N0147
CAS No.: 84-26-4
Synonyms: Rutecarpine
Category:  

Alkaloids Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Cancer Indole Alkaloids

Target:  

COX Keap1-Nrf2

Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB).
6
Epmedin C
Epmedin C
0 Images
6 Cited Publications
Cat. No.: HY-N0260
CAS No.: 110642-44-9
Synonyms: Epimedin-C; Baohuoside-VI
Category:  

Flavonols Flavonoids Monophenols Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields Inflammation/Immunology

Target:  

Keap1-Nrf2 CDK Caspase

Epmedin C (Epimedin-C; Baohuoside-VI) is an orally active anti-inflammatory agent and immunomodulator that binds to multiple key proteins including UCP1, Caspase-1, CDK2 and Keap1. Epmedin C inhibits epithelial cell proliferation by disrupting the complex function of CDK2/Cyclin E. Epmedin C also upregulates Nrf2 expression, reduces ROS levels and inhibits pro-inflammatory cytokine secretion, thereby effectively restoring antibody production and alleviating tissue damage. Epmedin C has good safety with no hepatotoxicity or skin sensitization, and it has been used in studies on diseases such as obesity, Deoxynivalenol (HY-N6684)-induced immunotoxicity and mammary hyperplasia [1] [2] .
4
Citraconic acid
Citraconic acid
0 Images
4 Cited Publications
Cat. No.: HY-113298
CAS No.: 498-23-7
Purity:  98.73%
Synonyms: Methylmaleic acid
Category:  

Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)

Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) [1] [2] .
4
KEAP1 Protein, Human (sf9)
KEAP1 Protein, Human (sf9)
0 Images
4 Cited Publications
Cat. No.: HY-P75897
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; Keap1; Keap1
Species:  
Human
Source:  
Sf9 insect cells
3
Sweroside
Sweroside
0 Images
3 Cited Publications
Cat. No.: HY-N0806
CAS No.: 14215-86-2
Category:  

Monophenols Labiatae Lespedeza tomentosa (Thunb.) Siebold ex Maxim. Metabolic Disease Phenols Plants Disease Research Fields

Target:  

Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP

Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields [1] [2] .
3
CBR-470-1
CBR-470-1
0 Images
3 Cited Publications
Cat. No.: HY-134205A
CAS No.: 2416095-06-0
Purity:  98.02%
Target:  

Keap1-Nrf2

Research Areas:  

Neurological Disease Metabolic Disease

CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP +-induced cytotoxicity through activation of the Keap1-Nrf2 cascade [1] [2].
3
(1R,3R)-RSL3
(1R,3R)-RSL3
0 Images
3 Cited Publications
Cat. No.: HY-100218C
CAS No.: 1219810-15-7
Purity:  99.52%
Target:  

Drug Isomer Ferroptosis

Research Areas:  

Cancer

(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells [1].
2
(R)-Sulforaphane
(R)-Sulforaphane
0 Images
2 Cited Publications
Cat. No.: HY-13755A
CAS No.: 142825-10-3
Purity:  99.48%
Synonyms: L-Sulforaphane
Category:  

Natural Products other families Plants Disease Research Fields Cancer

Target:  

Keap1-Nrf2 Bcl-2 Family Caspase Reactive Oxygen Species (ROS) NF-κB

(R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and AP-1. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses [1] [2] .
2
Nrf2 activator-2
Nrf2 activator-2
0 Images
2 Cited Publications
Cat. No.: HY-145879
CAS No.: 2770448-53-6
Purity:  99.20%
Target:  

Keap1-Nrf2

Research Areas:  

Cancer

Nrf2 activator-2 is an Nrf2 activator with binding affinity for Keap1, with an EC50 of 2.9 μM. Nrf2 activator-2 binds to Keap1, stabilizes the protein, inhibits the Keap1-Nrf2 interaction, and reduces the ubiquitination level of Nrf2. Nrf2 activator-2 can be used in cancer-related research [1].
2
KEAP1 Protein, Mouse (His, SUMO)
KEAP1 Protein, Mouse (His, SUMO)
0 Images
2 Cited Publications
Cat. No.: HY-P702829
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; Keap1; Keap1
Species:  
Mouse
Source:  
E. coli
2
Vialinin A
Vialinin A
0 Images
2 Cited Publications
Cat. No.: HY-103435
CAS No.: 858134-23-3
Purity:  99.90%
Synonyms: Terrestrin A
Target:  

Deubiquitinase TNF Receptor E1/E2/E3 Enzyme Keap1-Nrf2

Research Areas:  

Inflammation/Immunology Cancer

Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke [1] [2] .
2
Curcumin (Standard)
Curcumin (Standard)
0 Images
2 Cited Publications
Cat. No.: HY-N0005R
CAS No.: 458-37-7
Synonyms: Diferuloylmethane (Standard); Natural Yellow 3 (Standard); Turmeric yellow (Standard)
Category:  

Microorganisms Phenols Polyphenols Plants Curcuma longa Zingiberaceae

Target:  

Reference Standards Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis

Curcumin (Standard) is the analytical standard of Curcumin (HY-N0005). This product is intended for research and analytical applications. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
2
Curdione
Curdione
0 Images
2 Cited Publications
Cat. No.: HY-N0353
CAS No.: 13657-68-6
Synonyms: (+)-Curdione
Category:  

Terpenoids Sesquiterpenes Other Diseases Plants Curcuma phaeocaulis Valeton Disease Research Fields Zingiberaceae

Target:  

Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)

Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC50 = 1.1 μM) and cyclooxygenase 2 expression [1] [2] .
Assay Types