14907-98-3
Chemical Structure
Brusatol
Synonym(s): NSC 172924
- CAS No.: 14907-98-3
- Formula:C26H32O11
- Molecular Weight:520.53
IUPAC Name: methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate
InChIKey: ZZZYHIMVKOHVIH-VILODJCFSA-N
SMILES: CC([C@](C[C@@](O1)2[H])3[H])=C(O)C(C[C@]3(C)[C@]4([H])[C@]2(CO[C@@]5([C@@H](O)[C@@H]4O)C(OC)=O)[C@@]5([H])[C@@H](OC(/C=C(C)/C)=O)C1=O)=O
Biological Activity: Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent[1]. Brusatol increases cellular apoptosis[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Brusatol | 99.94% | Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent. Brusatol increases cellular apoptosis. | ||||||||||||||||||||
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Brusatol (Standard) | ≥98% | Brusatol (Standard) is the analytical standard of Brusatol (HY-19543). This product is intended for research and analytical applications. Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent. Brusatol increases cellular apoptosis. | ||||||||||||||||||||
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Similarity Score 0.92
HY-N0840Bruceantin -
Similarity Score 0.90
HY-N3013Bruceine B -
Similarity Score 0.88
HY-N0841Bruceine A -
Similarity Score 0.86
HY-N8146Bruceantinol -
Similarity Score 0.84
HY-N13474Bruceantinol B -
Similarity Score 0.81
HY-N10897Bruceantinol A -
Similarity Score 0.76
HY-N17946Dehydrobrusatol -
Similarity Score 0.74
HY-N20733Bruceoside B -
Similarity Score 0.71
HY-N7549Dehydrobruceantin -
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References
- [1]. Dongmei Ren, et al. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1433-8. [Content Brief]
- [2]. Hai-Ming Chen, et al. Synergistic antitumor effect of brusatol combined with cisplatin on colorectal cancer cells. Int J Mol Med. 2018 Mar;41(3):1447-1454. [Content Brief]
