2770448-53-6
Chemical Structure
Nrf2 activator-2
- CAS No.: 2770448-53-6
- Formula:C20H17BrO3
- Molecular Weight:385.25
IUPAC Name: (2R,4S)-1-((S)-2-(7-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: AWBUMGZRUKQFIN-UHFFFAOYSA-N
SMILES: CC1(CCC2=C3OC(C(C4=CC=CC=C4)=CC3=CC(Br)=C2O1)=O)C
Biological Activity: Nrf2 activator-2 is an Nrf2 activator with binding affinity for Keap1, with an EC50 of 2.9 μM. Nrf2 activator-2 binds to Keap1, stabilizes the protein, inhibits the Keap1-Nrf2 interaction, and reduces the ubiquitination level of Nrf2. Nrf2 activator-2 can be used in cancer-related research[1].
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Nrf2 activator-2 | 99.20% | Nrf2 activator-2 is an Nrf2 activator with binding affinity for Keap1, with an EC50 of 2.9 μM. Nrf2 activator-2 binds to Keap1, stabilizes the protein, inhibits the Keap1-Nrf2 interaction, and reduces the ubiquitination level of Nrf2. Nrf2 activator-2 can be used in cancer-related research. | ||||||||||||||||||||
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