1 Result for "

Lasiokaurin

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Lasiokaurin" in MCE Product Catalog:

1
Lasiokaurin
Lasiokaurin
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1 Cited Publications
Cat. No.: HY-123467
CAS No.: 28957-08-6
Purity:  99.68%
Category:  

Labiatae Erythrina sacleuxii Hua Terpenoids Diterpenoids Plants Disease Research Fields Cancer

Target:  

Apoptosis Polo-like Kinase (PLK) PDK-1 Akt mTOR STAT p38 MAPK NF-κB DNA/RNA Synthesis Autophagy

Lasiokaurin is an anticancer agent. Lasiokaurin can be isolated from Rabdosia rubescens (Hemsl.) H. Hara. Lasiokaurin inhibits the function of the PDPK1-AKT axis, with a Kd value of 75.93 μM for PDPK1. Lasiokaurin inhibits mTOR, STAT3, MAPK and NF-κB. Lasiokaurin reduces the mRNA and protein expression levels of PLK1. Lasiokaurin decreases DNA synthesis levels, induces cell Apoptosis, and regulates Autophagy processes. Lasiokaurin inhibits tumor growth in xenograft models. Lasiokaurin can be used in research related to nasopharyngeal carcinoma, triple-negative breast cancer .
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