19 Results for "

Melittin

" in MedChemExpress (MCE) Product Catalog:
Products (19)

19 Results for "Melittin" in MCE Product Catalog:

17
17 Cited Publications
Cat. No.: HY-P0233
CAS No.: 20449-79-0
Target:  

Phospholipase

Research Areas:  

Inflammation/Immunology Cancer

Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2 .
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17
17 Cited Publications
Cat. No.: HY-P0233A
Target:  

Phospholipase

Research Areas:  

Infection Cancer

Melittin TFA is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2 .
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Cat. No.: HY-P3383
CAS No.: 850761-47-6
Synonyms: PL-5
Target:  

Bacterial

Research Areas:  

Infection

Peceleganan (PL-5) is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan inhibits wound infection .
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Cat. No.: HY-P3914
CAS No.: 157606-25-2
Synonyms: Oct-CA(1-7)M(2-9)
Target:  

Bacterial

Research Areas:  

Infection

Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides .
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Cat. No.: HY-101015A
CAS No.: 134531-42-3
Purity:  99.27%
Target:  

Phospholipase Apoptosis

Research Areas:  

Inflammation/Immunology

OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM .
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Cat. No.: HY-P3328A
Target:  

Bacterial

Research Areas:  

Infection

MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa .
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Cat. No.: HY-132604A
CAS No.: 2175009-09-1
Purity:  93.86%
Synonyms: ARO-AAT sodium
Research Areas:  

Metabolic Disease

Fazirsiran sodium is a second-generation RNAi agent. Fazirsiran sodium consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes . Fazirsiran sodium can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. AATD is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene.
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Cat. No.: HY-P3383A
Synonyms: PL-5 acetate
Target:  

Bacterial

Research Areas:  

Infection

Peceleganan (PL-5) acetate is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan acetate inhibits wound infection .
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Cat. No.: HY-P3906
CAS No.: 123168-46-7
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways .
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Cat. No.: HY-132604
CAS No.: 2175009-08-0
Synonyms: ARO-AAT
Research Areas:  

Metabolic Disease

Fazirsiran (ARO-AAT) is a second-generation RNAi agent. Fazirsiran consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively reduce Alpha1-antitrypsin (AAT) synthesis and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes . Fazirsiran can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. Alpha-1 antitrypsin deficiency (AATD) is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene.
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Cat. No.: HY-P11191
CAS No.: 590424-23-0
Target:  

Bacterial

Research Areas:  

Infection

AR-23 is a melittin-related antimicrobial peptide that can be isolated from Rana tagoi. AR-23 exhibits broad-spectrum growth inhibitory activity against aerobic bacteria, the opportunistic yeast pathogen Candida albicans and clinical isolates of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). AR-23 can be used for antimicrobial research .
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Cat. No.: HY-P5552
Target:  

Bacterial Parasite Fungal

Research Areas:  

Infection

Melimine is a hybrid antimicrobial peptide of Melittin (HY-P0233) and Protamine. Melimine is active against P. aeruginosa and S. aureus. Melimine has broad spectrum activity against bacteria, fungi and protozoa .
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Cat. No.: HY-101015
CAS No.: 221632-26-4
Target:  

Phospholipase Apoptosis

Research Areas:  

Inflammation/Immunology

(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM .
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Cat. No.: HY-P2791
CAS No.: 58694-52-3
Tertiapin (reduced) is a kind of synthesis of melittin, its Cys3-Cys14 and Cys5-Cys18 between containing a disulfide bond. Tertiapin (reduced) is a kind of inward rectifier potassium channels blockers, can block the activity of calcium activates large conductance potassium channels. Tertiapin (reduced) can be used for research in diseases such as rheumatoid arthritis and multiple sclerosis .
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Cat. No.: HY-P3328
Target:  

Bacterial

Research Areas:  

Infection

MDP1, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa .
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Cat. No.: HY-P0233AS
Research Areas:  

Infection Cancer

Melittin- 13C18, 15N3 TFA is the 15N- and 13C-labeled Melittin TFA (HY-P0233A). Melittin TFA is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.
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Cat. No.: HY-P11909
Research Areas:  

Infection

3-WP is a linear 20-peptide with a C-terminal amidation modification. 3-WP acts on lipoteichoic acid (LTA) and disrupts cell wall permeability, induces intracellular reactive oxygen species (ROS) accumulation in a dose-dependent manner, and simultaneously inhibits respiratory chain dehydrogenase activity and intracellular ATP synthesis, thereby interfering with bacterial energy metabolism and exerting Bacterial antibacterial effects. The combination of 3-WP and Melittin (HY-P0233) exerts synergistic antibacterial effects against Gram-positive bacteria, reduces the required dosage of Melittin, and thus improves the cell selectivity of Melittin. 3-WP can serve as a peptide adjuvant for Melittin in food storage scenarios. 3-WP can be used in the research of foodborne diseases caused by methicillin-resistant Staphylococcus aureus .
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Cat. No.: HY-P11784
CAS No.: 1423724-82-6
Target:  

Peptides

Research Areas:  

Others

p5RHH is an acid-activated membrane-lytic peptide derived from melittin. p5RHH, as a siRNA delivery vector, initiates synchronous disassembly of nanocomplexes and endosome lysis in response to acidic pH, and triggers the release of siRNA into the cytoplasm following macropinocytosis .
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Cat. No.: HY-D3382
Target:  

Fluorescent Dye

Research Areas:  

Others

SGC3 is a fluorescent dye with lipophilic properties. SGC3 can be used to study synaptic vesicle recycling and "kiss-and-run" exocytosis by monitoring dye efflux through nanoscale fusion pores, and its detection mechanism relies on its own lipophilic properties. SGC3 generates fluorescence when bound to lipid membranes, and a decrease in fluorescence intensity can be detected when SGC3 leaves vesicles and exists in a free state in solution .
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