Peceleganan
Based on 1 Customer Validation
Peceleganan (PL-5) is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan inhibits wound infection.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.61%
- CAS. Nr.: 850761-47-6
- Formel: C₁₃₈H₂₂₆N₃₆O₃₄
- Molecular Weight:2933.50
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Peceleganan (24 h) shows antibacterial activity with MICs of 2, 2, 4, 4, 4 and 8 μM against E. coli ATCC 25922, S. pneumonia ATCC 49619, K. pneumonia ATCC 700603, S. aureus ATCC 25923, S. epidermidis ATCC 12228 and P. aeruginosa ATCC 27853, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR male mice (20-25 g), S. aureus ATCC 25923 wound infection model[2]
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Dosage:0.4 and 0.75 mg/mL for 100 μL
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Administration:Transdermal administration, twice daily for 3 days
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Result:Significantly reduced the amount of bacteria.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 850761-47-6
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Appearance Solid
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Molecular Weight 2933.50
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Formel C₁₃₈H₂₂₆N₃₆O₃₄
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Color White to off-white
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Synonyms
PL-5
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Sequence Shortening
Ac-KWKSFLKTFKSAAKTVLHTALKAISS-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : 1.96 mg/mL (0.67 mM; ultrasonic and adjust pH to 4 with 1 M HCL; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical.
[2]. Feng Q, et al. Functional synergy of α-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):197-204. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Peceleganan Related Classifications
HY-P3383 Related Classifications
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