965 Results for "

NSC

" in MedChemExpress (MCE) Product Catalog:
Products (965)

965 Results for "NSC" in MCE Product Catalog:

1369
Rapamycin
Rapamycin
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1369 Publications Verification
Cat. No.: HY-10219
CAS No.: 53123-88-9
Pureté:  99.94%
Synonyms: Sirolimus; AY-22989; NSC 226080
Category:  

Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Anti-aging Antibiotics Disease Research Disease Research Fields Cancer

Target:  

mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial

Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
261
Bortezomib
Bortezomib
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261 Cited Publications
Cat. No.: HY-10227
CAS No.: 179324-69-7
Pureté:  99.91%
Synonyms: PS-341; LDP-341; NSC 681239
Target:  

Proteasome NF-κB Apoptosis Autophagy TREM receptor Ligands for Target Protein for PROTAC

Domaines de recherche:  

Cancer

Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .
193
Temozolomide
Temozolomide
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193 Cited Publications
Cat. No.: HY-17364
CAS No.: 85622-93-1
Synonyms: NSC 362856; CCRG 81045; TMZ
Target:  

DNA Alkylator/Crosslinker Autophagy Apoptosis

Domaines de recherche:  

Cancer

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .
172
Decitabine
Decitabine
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172 Cited Publications
Cat. No.: HY-A0004
CAS No.: 2353-33-5
Synonyms: 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716
Target:  

DNA Methyltransferase Apoptosis Nucleoside Antimetabolite/Analog

Domaines de recherche:  

Infection Inflammation/Immunology Cancer

Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell Apoptosis. Decitabine has potent anticancer activity .
138
Erlotinib Hydrochloride
Erlotinib Hydrochloride
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138 Cited Publications
Cat. No.: HY-12008
CAS No.: 183319-69-9
Pureté:  99.94%
Synonyms: CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride
Target:  

EGFR Autophagy

Domaines de recherche:  

Cancer

Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
138
Erlotinib
Erlotinib
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138 Cited Publications
Cat. No.: HY-50896
CAS No.: 183321-74-6
Synonyms: CP-358774; NSC 718781; OSI-774
Target:  

EGFR Autophagy

Domaines de recherche:  

Cancer

Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer . Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
138
Streptozotocin
Streptozotocin
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138 Cited Publications
Cat. No.: HY-13753
CAS No.: 18883-66-4
Pureté:  99.20%
Synonyms: Streptozocin; NSC-85998; U 9889
Category:  

Microorganisms Antibiotics Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:  

DNA/RNA Synthesis DNA Alkylator/Crosslinker Autophagy Bacterial Antibiotic Apoptosis

Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells .
106
Fludarabine
Fludarabine
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106 Cited Publications
Cat. No.: HY-B0069
CAS No.: 21679-14-1
Synonyms: F-ara-A; NSC 118218
Target:  

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis STAT Apoptosis

Domaines de recherche:  

Cancer

Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes .
94
Carboplatin
Carboplatin
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94 Cited Publications
Cat. No.: HY-17393
CAS No.: 41575-94-4
Synonyms: NSC 241240
Target:  

DNA Alkylator/Crosslinker Autophagy DNA/RNA Synthesis

Domaines de recherche:  

Cancer

Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
92
Cytochalasin D
Cytochalasin D
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92 Cited Publications
Cat. No.: HY-N6682
CAS No.: 22144-77-0
Synonyms: Zygosporin A; NSC 209835
Category:  

Infection Natural Products Microorganisms Disease Research Fields

Target:  

Exosomes Arp2/3 Complex Antibiotic YAP

Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .
81
Sulfasalazine
Sulfasalazine
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81 Cited Publications
Cat. No.: HY-14655
CAS No.: 599-79-1
Pureté:  98.75%
Synonyms: NSC 667219
Target:  

NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic

Domaines de recherche:  

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .
75
Vincristine
Vincristine
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75 Cited Publications
Cat. No.: HY-N0488A
CAS No.: 57-22-7
Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
Category:  

Apocynaceae Alkaloids Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:  

Apoptosis Microtubule/Tubulin Mitosis

Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
75
Vincristine sulfate
Vincristine sulfate
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75 Cited Publications
Cat. No.: HY-N0488
CAS No.: 2068-78-2
Synonyms: Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate
Category:  

Apocynaceae Alkaloids Anti-aging Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:  

Apoptosis Microtubule/Tubulin Mitosis

Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) sulfate is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
72
Romidepsin
Romidepsin
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72 Cited Publications
Cat. No.: HY-15149
CAS No.: 128517-07-7
Pureté:  99.87%
Synonyms: FK 228; FR 901228; NSC 630176
Target:  

HDAC Apoptosis

Domaines de recherche:  

Cancer

Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .
69
Tanespimycin
Tanespimycin
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69 Cited Publications
Cat. No.: HY-10211
CAS No.: 75747-14-7
Pureté:  99.01%
Synonyms: 17-AAG; NSC 330507; CP 127374
Target:  

HSP Autophagy Mitophagy Bacterial Apoptosis Antibiotic

Domaines de recherche:  

Infection Cancer

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90 . Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression .
67
GANT 61
GANT 61
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67 Cited Publications
Cat. No.: HY-13901
CAS No.: 500579-04-4
Pureté:  99.66%
Synonyms: NSC 136476
Target:  

Gli Autophagy

Domaines de recherche:  

Cancer

GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
66
Honokiol
Honokiol
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66 Cited Publications
Cat. No.: HY-N0003
CAS No.: 35354-74-6
Synonyms: NSC 293100
Category:  

Magnolia officinalis. Rehd. et Wils. Magnoliaceae Lignans Phenylpropanoids Plants Disease Research Fields Cancer

Target:  

Akt Autophagy HCV ERK

Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier .
62
NSC 74859
NSC 74859
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62 Cited Publications
Cat. No.: HY-15146
CAS No.: 501919-59-1
Pureté:  98.35%
Synonyms: S3I-201
Target:  

STAT

Domaines de recherche:  

Cancer

NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM .
54
NSC 23766 trihydrochloride
NSC 23766 trihydrochloride
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54 Cited Publications
Cat. No.: HY-15723A
CAS No.: 1177865-17-6
Pureté:  99.41%
Target:  

Ras Apoptosis

Domaines de recherche:  

Cancer

NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.
54
NSC 23766
NSC 23766
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54 Cited Publications
Cat. No.: HY-15723
CAS No.: 733767-34-5
Pureté:  99.86%
Target:  

Ras

Domaines de recherche:  

Cancer

NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment.
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