2 Results for "

Naamidine J

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Naamidine J" in MCE Product Catalog:

Cat. No.: HY-N14001
CAS No.: 2227550-73-2
Naamidine J is an imidazole-type alkaloids discovered in a sponge. Naamidine J inhibits inflammation by binding to the protein CSE1L (KD = 5.41 μM). Namidine J significantly inhibits the expression of pro-inflammatory factors such as TNF-α, IL-1β, and IL-6, and upregulates anti-inflammatory factors such as CD206 and Arg-1. Namidine J inhibits PD-L1 and shows antitumor activity. Namidine J significantly reduces pulmonary tissue edema, inflammatory cell infiltration and cytokine storm in mice. Namidine J can be used for the research on the immune microenvironment of acute lung injury and tumors .
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1
1 Cited Publications
Cat. No.: HY-149830
CAS No.: 2894733-91-4
Purity:  98.66%
Target:  

PD-1/PD-L1

Research Areas:  

Cancer

PD-L1-IN-2 is a potential tumor immunological agent by inhibiting PD-L1. PD-L1-IN-2 is a Naamidine J derivative and exerts antitumor effects in vivo by reducing PD-L1 expression and enhancing tumor-infiltrating T-cell immunity. PD-L1-IN-2 is used for colorectal cancer research .
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