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Results for "

PM1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Adrenergic Receptor (1) Akt (2) Aldehyde Dehydrogenase (ALDH) (1) Antibiotic (2) Apoptosis (1) Aryl Hydrocarbon Receptor (1) Bacterial (1) Biochemical Assay Reagents (2) C-type Lectin-like Receptors (CTLRs) (1) Caspase (1) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) Elastase (1) Endogenous Metabolite (2) Endothelin Receptor (1) Fluorescent Dye (1) Fungal (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (1) Integrin (2) JAK (1) Kisspeptin Receptor (2) mAChR (1) Molecular Glues (1) nAChR (2) Necroptosis (1) Phosphatase (3) Phosphodiesterase (PDE) (3) Phospholipase (2) Potassium Channel (1) Prostaglandin Receptor (1) Reference Standards (3) Small Interfering RNA (siRNA) (1) STING (1) Tie (3)
By Research Areas:	Cancer (14) Cardiovascular Disease (2) Endocrinology (2) Infection (2) Inflammation/Immunology (10) Metabolic Disease (2) Neurological Disease (7)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3152

Streptavidin 5 Publications Verification	Biochemical Assay Reagents	Others
Streptavidin is a ~60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a K_D ~0.01 pM . Streptavidin has an immunosuppressive role . This product is a Streptavidin protein recombinantly expressed in an E. coli expression system.

HY-150096

Zasocitinib 1 Publications Verification NDI-034858; TAK-279	JAK	Inflammation/Immunology
Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant K_d of <200 pM .

HY-109041

Razuprotafib 4 Publications Verification AKB-9778	Phosphatase Tie	Inflammation/Immunology
Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC₅₀of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM) .

HY-121251

BI-167107 2 Publications Verification	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
BI-167107 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constant K_d of 84 pM .

HY-106101

Echinomycin 10+ Cited Publications Quinomycin A; NSC-13502	HIF/HIF Prolyl-Hydroxylase Antibiotic Bacterial	Cancer
Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC₅₀ of 29.4 pM .

HY-12456

Duocarmycin SA	Antibiotic ADC Payload DNA Alkylator/Crosslinker Necroptosis Apoptosis	Cancer
Duocarmycin SA is an orally active antitumor antibiotic with an IC₅₀ of 10 pM . Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro .

HY-P99389

Tesnatilimab JNJ-64304500; IPH-2301; NN-8555	C-type Lectin-like Receptors (CTLRs)	Inflammation/Immunology
Tesnatilimab (JNJ-64304500) is a human IgG4 monoclonal antibody targeting NKG2D, with a K_D value of 9.2 pM . Tesnatilimab blocks the binding of ligands to the NKG2D receptor, thereby inhibiting downstream proinflammatory cytokine, cytotoxic mediator signaling pathways and proinflammatory immune responses. Tesnatilimab is applicable to research related to Crohn's disease ^[1] .

HY-156404

*PM-1* 2 Publications Verification	Fluorescent Dye	Others
PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins ^[1].

HY-10425

Rizavasertib Maximum Cited Publications 12 Publications Verification A-443654	Akt	Cancer
A-443654 is a pan-Akt inhibitor and has equal potency against *Akt1, Akt2, or Akt3* within cells (K_i=160 pM) .

HY-14316A

Tebanicline dihydrochloride Ebanicline dihydrochloride; ABT-594 dihydrochloride	nAChR	Neurological Disease
Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a K_i of 37 pM .

HY-P0076A

TAK-448 acetate 3 Publications Verification MVT-602 acetate	Kisspeptin Receptor	Cancer
TAK-448 acetate (MVT-602 acetate) is a potent and full *KISS1R* agonist with an IC₅₀ of 460 pM and an EC₅₀ of 632 pM .

HY-P0076

TAK-448 3 Publications Verification MVT-602	Kisspeptin Receptor	Cancer
TAK-448 (MVT-602) is a potent and full *KISS1R* agonist with an IC₅₀ of 460 pM and an EC₅₀ of 632 pM .

HY-102004

Rilapladib 3 Publications Verification SB 659032	Phospholipase	Neurological Disease Inflammation/Immunology
Rilapladib (SB 659032) is a selective Lp-PLA₂ (lipoprotein-associated phospholipase A₂) inhibitor with an IC₅₀ of 230 pM . Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist .

HY-16465A

IRL-1620 TFA 1 Publications Verification	Endothelin Receptor	Cardiovascular Disease Neurological Disease Endocrinology
IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM .

HY-P1187

HSDVHK-NH2	Integrin	Cancer
HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM) .

HY-122641C

Deltasonamide 2 hydrochloride 1 Publications Verification	Phosphodiesterase (PDE)	Cancer
Deltasonamide 2 hydrochloride is a competitive, high affinity PDEδ inhibitor with a K_d of ~385 pM .

HY-122641B

Deltasonamide 2 TFA 1 Publications Verification	Phosphodiesterase (PDE)	Cancer
Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a K_d of ~385 pM .

HY-139972

PROTAC(H-PGDS)-7	Molecular Glues Prostaglandin Receptor	Cardiovascular Disease
PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader, with a DC₅₀ of 17.3 pM .

HY-153782

GSK878	HIV	Infection
GSK878 is a highly potent, long-acting *HIV-1* inhibitor with the EC₅₀ of 39 pM .

HY-19908B

(R)-BAY-85-8501 1 Publications Verification	Elastase	Metabolic Disease
(R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC₅₀ of 65 pM .

HY-127127

Deamino-NAD	Endogenous Metabolite	Others
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-171012

Clonixeril NSC 335504	STING	Inflammation/Immunology
Clonixeril (NSC 335504) is a non-nucleotide hSTING modulator. Clonixeril has weak agonist activity at micromolar concentrations and results in antagonism of the hSTING ^WT pathway at low femtomolar (10 ^-15 M) and in some cases even attomolar (10 ^-18 M) concentrations. Clonixeril reduces hSTING oligomerization at a concentration of 1 aM-1 pM .

HY-RS14651

TMEM11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMEM11 Human Pre-designed siRNA Set A contains three designed siRNAs for TMEM11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMEM11 Human Pre-designed siRNA Set A TMEM11 Human Pre-designed siRNA Set A

HY-122641A

Deltasonamide 2	Phosphodiesterase (PDE)	Cancer
Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a K_d of ~385 pM .

HY-P4535

Ac-Trp-Glu-His-Asp-Aldehyde	Caspase	Inflammation/Immunology
Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective *caspase-1* inhibitor with a K_i value of 56 pM .

HY-176417

Antifungal agent 132	Fungal	Infection
Antifungal agent 132 (compound 25) is a selective and potent antifungal agent. Antifungal agent 132 inhibits Cryptococcus neoformans May1 with a K_i of 180 pM .

HY-14316B

Tebanicline hydrochloride Ebanicline hydrochloride; ABT-594 hydrochloride	nAChR	Neurological Disease
Tebanicline hydrochloride (Ebanicline hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. Tebanicline hydrochloride inhibits the binding of cytisine to α4β2 neuronal nAChRs with a K_i of 37 pM .

HY-P1187A

HSDVHK-NH2 TFA	Integrin	Cancer
HSDVHK-NH2 TFA is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM) .

HY-127127A

Deamino-NAD sodium	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Metabolic Disease
Deamino-NAD sodium is a structural analog of NAD+ (HY-B0445). Deamino-NAD sodium is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-120842

RLH-033	mAChR	Neurological Disease
RLH-033 is a potent and selective ligand for the sigma 1 recognition site. RLH-033 has high affinity for sigma 1 sites labeled by [ ³H](+)-pentazocine with a K_i of 50 pM .

HY-162045

Ru-4T	Biochemical Assay Reagents	Cancer
Ru-4T is a phototherapy agent. Ru-4T has phototherapeutic efficacy (PI = 114,000) against melanoma cells (SK-MEL-28) under broad-band visible light (400-700 nm) with EC₅₀ values of 740 pM .

HY-P1274

ShK-Dap22	Potassium Channel	Inflammation/Immunology
ShK-Dap22 is a potent *Kv1.3*-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC₅₀s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively ^[1].

HY-161649

hCYP1B1-IN-2	Cytochrome P450 Aryl Hydrocarbon Receptor	Cancer
hCYP1B1-IN-2 (compound 3n) is a potent human cytochrome P450 1B1 enzyme hCYP1B1 inhibitor. hCYP1B1-IN-2 shows the extremely potent anti-hCYP1B1 activity (IC₅₀=0.040 nM) and blocks AhR transcription activity. hCYP1B1-IN-2 potently inhibits hCYP1B1 via a mix inhibition manner, showing a K_i value of 21.71 pM .

HY-10425R

Rizavasertib (Standard) A-443654 (Standard)	Reference Standards Akt	Cancer
Rizavasertib (Standard) is the analytical standard of Rizavasertib (HY-10425). This product is intended for research and analytical applications. A-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM) .

HY-102004R

Rilapladib (Standard) SB 659032 (Standard)	Reference Standards Phospholipase	Neurological Disease Inflammation/Immunology
Rilapladib (Standard) is the analytical standard of Rilapladib (HY-102004). This product is intended for research and analytical applications. Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC₅₀ of 230 pM . Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist .

HY-109041A

Razuprotafib sodium AKB-9778 sodium	Phosphatase Tie	Inflammation/Immunology
Razuprotafib (AKB-9778) sodium is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC₅₀of 17 pM. Razuprotafib sodium promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib sodium inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib sodium shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM) .

HY-109041R

Razuprotafib (Standard) AKB-9778 (Standard)	Reference Standards Phosphatase Tie	Inflammation/Immunology
Razuprotafib (Standard) is the analytical standard of Razuprotafib (HY-109041). This product is intended for research and analytical applications. Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC₅₀of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM) .

Cat. No.	Product Name	Type

HY-156404

*PM-1* 2 Publications Verification	Fluorescent Dye
PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins ^[1].

PM-1

2 Publications Verification

Fluorescent Dye

PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins ^[1].

Cat. No.	Product Name	Type

HY-P3152

Streptavidin 5 Publications Verification	Biochemical Assay Reagents
Streptavidin is a ~60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a K_D ~0.01 pM . Streptavidin has an immunosuppressive role . This product is a Streptavidin protein recombinantly expressed in an E. coli expression system.

Cat. No.	Product Name	Target	Research Area

HY-P0076A

TAK-448 acetate 3 Publications Verification MVT-602 acetate	Kisspeptin Receptor	Cancer
TAK-448 acetate (MVT-602 acetate) is a potent and full *KISS1R* agonist with an IC₅₀ of 460 pM and an EC₅₀ of 632 pM .

HY-P0076

TAK-448 3 Publications Verification MVT-602	Kisspeptin Receptor	Cancer
TAK-448 (MVT-602) is a potent and full *KISS1R* agonist with an IC₅₀ of 460 pM and an EC₅₀ of 632 pM .

HY-16465A

IRL-1620 TFA 1 Publications Verification	Endothelin Receptor	Cardiovascular Disease Neurological Disease Endocrinology
IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM .

HY-P1187

HSDVHK-NH2	Integrin	Cancer
HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM) .

HY-P4535

Ac-Trp-Glu-His-Asp-Aldehyde	Caspase	Inflammation/Immunology
Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective *caspase-1* inhibitor with a K_i value of 56 pM .

HY-P1187A

HSDVHK-NH2 TFA	Integrin	Cancer
HSDVHK-NH2 TFA is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM) .

HY-P1274

ShK-Dap22	Potassium Channel	Inflammation/Immunology
ShK-Dap22 is a potent *Kv1.3*-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC₅₀s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99389

Tesnatilimab JNJ-64304500; IPH-2301; NN-8555	C-type Lectin-like Receptors (CTLRs)	Inflammation/Immunology
Tesnatilimab (JNJ-64304500) is a human IgG4 monoclonal antibody targeting NKG2D, with a K_D value of 9.2 pM . Tesnatilimab blocks the binding of ligands to the NKG2D receptor, thereby inhibiting downstream proinflammatory cytokine, cytotoxic mediator signaling pathways and proinflammatory immune responses. Tesnatilimab is applicable to research related to Crohn's disease ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-127127

Deamino-NAD	Microorganisms Source Classification	Endogenous Metabolite
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

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PM1

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Oligonucleotides

Natural
Products