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1 Result for "
PNU-107484A
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "PNU-107484A" in MCE Product Catalog:
Cat. No.: HY-117106
CAS No.: 200266-76-8
Target:
Research Areas:
PNU-107484A is a GABAA receptor ligand that exhibits target activity mechanisms dependent on α isoforms. In the α1β2γ2 subtype, PNU-107484A acts as a positive allosteric modulator, enhancing GABA-induced Cl - currents, while it inhibits the currents in the α3β2γ2 and α6β2γ2 subtypes. The half-maximal concentrations for the α1β2γ2, α3β2γ2, and α6β2γ2 subtypes are 3.1, 4.2, and 3.5 μM, respectively. PNU-107484A can be used as a probe to investigate the physiological roles of different α isoform subtypes .
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