200266-76-8
Chemical Structure
PNU-107484A
- CAS No.: 200266-76-8
- Formula:C18H23ClN6
- Molecular Weight:358.87
IUPAC Name: 9-methyl-2,4-di(pyrrolidin-1-yl)-9H-pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine hydrochloride
InChIKey: NUPWOBTZHLNAGL-UHFFFAOYSA-N
SMILES: CN1C2=NC(N3CCCC3)=NC(N4CCCC4)=C2C5=C1C=CN=C5.Cl
Biological Activity: PNU-107484A is a GABAA receptor ligand that exhibits target activity mechanisms dependent on α isoforms. In the α1β2γ2 subtype, PNU-107484A acts as a positive allosteric modulator, enhancing GABA-induced Cl- currents, while it inhibits the currents in the α3β2γ2 and α6β2γ2 subtypes. The half-maximal concentrations for the α1β2γ2, α3β2γ2, and α6β2γ2 subtypes are 3.1, 4.2, and 3.5 μM, respectively. PNU-107484A can be used as a probe to investigate the physiological roles of different α isoform subtypes[1].
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PNU-107484A | PNU-107484A is a GABAA receptor ligand that exhibits target activity mechanisms dependent on α isoforms. In the α1β2γ2 subtype, PNU-107484A acts as a positive allosteric modulator, enhancing GABA-induced Cl- currents, while it inhibits the currents in the α3β2γ2 and α6β2γ2 subtypes. The half-maximal concentrations for the α1β2γ2, α3β2γ2, and α6β2γ2 subtypes are 3.1, 4.2, and 3.5 μM, respectively. PNU-107484A can be used as a probe to investigate the physiological roles of different α isoform subtypes. | |||||||||||||||||||||
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Keywords
