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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
PROTAC GPX4 degrader-1
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "PROTAC GPX4 degrader-1" in MCE Product Catalog:
Research Areas:
PROTAC GPX4 degrader-1 is a glutathione peroxidase 4 (GPX4) PROTAC degrader with a DC50 of 30 nM. PROTAC GPX4 degrader-1 induces ROS accumulation and ferroptosis in cancer cells. PROTAC GPX4 degrader-1 inhibits cell growth and reduces GPX4 levels in tumor tissues. PROTAC GPX4 degrader-1 can be used in research related to various cancers including fibrosarcoma, non-small cell lung cancer, and melanoma .
Cat. No.: HY-179384
CAS No.: 3096510-51-6
Target:
ACSL Family PROTACs Ferroptosis Glutathione Peroxidase Transferrin Receptor Reactive Oxygen Species (ROS)
Research Areas:
PROTAC FSP1 degrader 1 is a highly efficient and selective PROTAC degrader targeting FSP1. PROTAC FSP1 degrader 1 significantly induces the accumulation of intracellular lipid peroxides. PROTAC FSP1 degrader 1 exhibits synergistic induction of ferroptosis with GPX4 inhibitors. PROTAC FSP1 degrader 1 can induce ROS production. PROTAC FSP1 degrader 1 upregulates the mRNA expression of ferroptosis-related proteins (GPX4, FTH1, ACSL4, TfR1, FSP1). PROTAC FSP1 degrader 1 can be used for the study of triple-negative breast cancer .
Cat. No.: HY-401204
CAS No.: 2916434-69-8
Target:
Research Areas:
GPX4 ligand-2 (M6) is a ligands for target protein for PROTAC that specifically binds to GPX4. GPX4 ligand-2 can be used to synthesize PROTAC GPX4 degrader-1 (HY-149236) .
Cat. No.: HY-175936
CAS No.: 2916434-74-5
Target:
Research Areas:
NH2-C3-piperazin-Pip-Boc is a PROTAC linker that can be used to synthesize PROTAC GPX4 degrader-1 (HY-149236).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
