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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
PROTAC PDE4 degrader-1
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "PROTAC PDE4 degrader-1" in MCE Product Catalog:
Cat. No.: HY-174405
CAS No.: 3087311-36-9
Research Areas:
PROTAC PDE4 degrader-1 is an orally active CRBN-recruiting PDE4B PROTAC degrader. PROTAC PDE4 degrader-1 shows an IC50 of 1.9 μM against PDE4B, degrades PDE4B via the ubiquitin-proteasome pathway, and shows weak activity against PDE4C. PROTAC PDE4 degrader-1 inhibits the secretion of pro-inflammatory cytokines TNF-α and IL-6, reduces the infiltration of inflammatory cells into lung tissues, protects lung tissues and alleviates acute lung injury. PROTAC PDE4 degrader-1 can be used for the research of acute lung injury .
Cat. No.: HY-174410
Research Areas:
PDE4 ligand 2 is a CRBN E3 ligase ligand. PDE4 ligand 2 can be used to synthesize PROTAC such as PDE4 degrader-1 (HY-174405). PDE4 ligand 2 can be studied in research for autoimmune and anti-inflammatory diseases .
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Protocols
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