3087311-36-9
Chemical Structure
PROTAC PDE4 degrader-1
- CAS No.: 3087311-36-9
- Formula:C30H27F2N5O7S
- Molecular Weight:639.63
InChIKey: BAFLYJGTCNSPSX-UHFFFAOYSA-N
SMILES: O=C1CCC(C(N1)=O)N2C(C3=CC=CC(NCCNC(C4=CSC(C5=CC=C(C(OCC6CC6)=C5)OC(F)F)=N4)=O)=C3C2=O)=O
Biological Activity: PROTAC PDE4 degrader-1 (Compound 9m) is a selective and orally active PDE4 PROTAC degrader with a DC50 of 41.98 μM. PROTAC PDE4 degrader-1 potently inhibits the secretion of pro-inflammatory cytokines such as TNF-α and IL-6. PROTAC PDE4 degrader-1 significantly alleviates pulmonary inflammation in LPS (HY-D1056)-induced acute lung injury (ALI) mice Model[1].
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PROTAC PDE4 degrader-1 | PROTAC PDE4 degrader-1 (Compound 9m) is a selective and orally active PDE4 PROTAC degrader with a DC50 of 41.98 μM. PROTAC PDE4 degrader-1 potently inhibits the secretion of pro-inflammatory cytokines such as TNF-α and IL-6. PROTAC PDE4 degrader-1 significantly alleviates pulmonary inflammation in LPS (HY-D1056)-induced acute lung injury (ALI) mice Model. | |||||||||||||||||||||
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Keywords
