Search Result

Pathways Recommended:	PROTAC

Results for "

PROTAC TEAD/IAP degrader-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IAP (3) Ligands for Target Protein for PROTAC (2) SNIPERs (2) E3 Ligase Ligand-Linker Conjugates (1) Ligands for E3 Ligase (2) PROTACs (2) YAP (5)
By Research Areas:	Cancer (6)
Click Chemistry:	PROTAC Synthesis (3)

Inhibitors & Agonists

Click Chemistry

Targets Recommended: IAP PROTAC-Linker Conjugates for PAC PROTAC Linkers SNIPERs Ligands for Target Protein for PROTAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-181594

**PROTAC TEAD/IAP degrader-1**	PROTACs SNIPERs YAP	Cancer
PROTAC TEAD/IAP degrader-1 is a *TEAD/IAP* *PROTAC* degrader. PROTAC TEAD/IAP degrader-1 is also a specific and Nongenetic inhibitor of apoptosis protein (IAP)-dependent protein eraser (SNIPERs). PROTAC TEAD/IAP degrader-1 recruits cIAP1 to form ternary complexes, induces ubiquitination, proteasomal *TEAD1, TEAD4* degradation. PROTAC TEAD/IAP degrader-1 inhibits TEAD transcriptional activity, reduces CTGF expression, and reduces cell proliferation. PROTAC TEAD/IAP degrader-1 can be used for the research of mesothelioma .

HY-181534

**PROTAC TEAD1/IAP degrader-1**	PROTACs YAP IAP SNIPERs	Cancer
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective *TEAD1* and cIAP1 *PROTAC* degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the *TEAD*-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

HY-181536

TEAD ligand 2	Ligands for Target Protein for PROTAC YAP	Cancer
TEAD ligand 2 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534). PROTAC TEAD1/IAP degrader-1 is a potent **TEAD1/IAP PROTAC** degrader with anti-cancer activity .

HY-181530

IAP ligand 6	YAP Ligands for E3 Ligase	Cancer
IAP ligand 6 (A250) is an *IAP* ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534) .

HY-181535

IAP ligand-Linker Conjugate 1	E3 Ligase Ligand-Linker Conjugates IAP	Others
IAP ligand-Linker Conjugate 1 is a ligand-linker conjugate targeting *IAP, which can be used in the synthesis of PROTAC* TEAD1/IAP degrader-1 (HY-181534) .

HY-181531

IAP ligand 7	Ligands for E3 Ligase IAP	Cancer
IAP ligand 7 is an E3 ligase ligand. IAP ligand 7 can be conjugated with TEAD ligand (HY-181595) and linker (HY-181608) to synthesize PROTAC TEAD/IAP degrader-1 (HY-181594) .

HY-181595

TEAD ligand 5	Ligands for Target Protein for PROTAC YAP	Cancer
TEAD ligand 5 (Compound S19) is a *TEAD* *PROTAC* ligand. TEAD ligand 5 can be conjugated with E3 ligase Ligand (HY-181531) and linker (HY-181608) to synthesize PROTAC TEAD/IAP degrader-1 (HY-181594) .

Cat. No.	Product Name		Classification

HY-181534

**PROTAC TEAD1/IAP degrader-1**		PROTAC Synthesis
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective *TEAD1* and cIAP1 *PROTAC* degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the *TEAD*-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

HY-181536

TEAD ligand 2		PROTAC Synthesis
TEAD ligand 2 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534). PROTAC TEAD1/IAP degrader-1 is a potent **TEAD1/IAP PROTAC** degrader with anti-cancer activity .

HY-181530

IAP ligand 6		PROTAC Synthesis
IAP ligand 6 (A250) is an *IAP* ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534) .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

We use cookies

MedChemExpress values your privacy and your trust is important to us. We use cookies to enhance your website experience. Some cookies are necessary to run the website. Privacy and Cookie Policy

Name
Email *

	Sorry, but the email address you supplied was invalid.