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Pathways Recommended:	PROTAC

Results for "

PROTAC TEAD degrader1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ligands for Target Protein for PROTAC (3) E3 Ligase Ligand-Linker Conjugates (2) IAP (3) Ligands for E3 Ligase (1) PROTACs (4) SNIPERs (2) YAP (7)
By Research Areas:	Cancer (9)
Click Chemistry:	PROTAC Synthesis (2)

Inhibitors & Agonists

Click Chemistry

Targets Recommended: PROTAC-Linker Conjugates for PAC PROTAC Linkers Ligands for Target Protein for PROTAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-158342

**PROTAC TEAD degrader-1**	PROTACs YAP	Cancer
PROTAC TEAD degrader-1 is a *TEAD2* degrader and antiproliferative agent with selective activity toward *TEAD2* relative to other *TEAD* family members. PROTAC TEAD degrader-1 relies on CRBN and the proteasome system for *TEAD2* degradation; disruption of CRBN binding attenuates this activity. PROTAC TEAD degrader-1 decreases expression of YAP target genes CYR61 and CTGF. PROTAC TEAD degrader-1 can be used for the research of NF2-deficient cancer .

HY-168016

PROTAC YAP degrader-1	PROTACs YAP	Cancer
PROTAC YAP degrader-1 is a VHL-recruiting *PROTAC* degrader (DC₅₀=8.2 μM) and antiproliferative agent that targets YAP. PROTAC YAP degrader-1 recruits the E3 ligase VHL and binds to VHL to form a ternary complex containing YAP. PROTAC YAP degrader-1 inhibits the nuclear localization of YAP in cancer cells, reduces *YAP/TEAD*-mediated transcription, and induces TAZ protein degradation. PROTAC YAP degrader-1 reduces the oncogenic activity of YAP and exerts antiproliferative effects in the Huh7 xenograft mouse model. PROTAC YAP degrader-1 can be used for the research of hepatocellular carcinoma and mesothelioma .

HY-181594

**PROTAC TEAD/IAP degrader-1**	PROTACs SNIPERs YAP	Cancer
PROTAC TEAD/IAP degrader-1 is a *TEAD/IAP* *PROTAC* degrader. PROTAC TEAD/IAP degrader-1 is also a specific and Nongenetic inhibitor of apoptosis protein (IAP)-dependent protein eraser (SNIPERs). PROTAC TEAD/IAP degrader-1 recruits cIAP1 to form ternary complexes, induces ubiquitination, proteasomal *TEAD1, TEAD4* degradation. PROTAC TEAD/IAP degrader-1 inhibits TEAD transcriptional activity, reduces CTGF expression, and reduces cell proliferation. PROTAC TEAD/IAP degrader-1 can be used for the research of mesothelioma .

HY-181534

**PROTAC TEAD1/IAP degrader-1**	PROTACs YAP IAP SNIPERs	Cancer
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective *TEAD1* and cIAP1 *PROTAC* degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the *TEAD*-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

HY-158400

TEAD ligand 1	Ligands for Target Protein for PROTAC YAP	Cancer
TEAD ligand 1 is the ligand for target protein *TEAD. TEAD* ligand 1 is utilized for synthesis of PROTAC TEAD degrader-1 (HY-158342) .

HY-158343

Thalidomide-NH-PEG2-C2-CH2	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-NH-PEG2-C2-CH2 is a conjugate of E3 ligase ligand and linker. Thalidomide-NH-PEG2-C2-CH2 is utilized for synthesis of PROTAC TEAD degrader-1 (HY-158342) .

HY-181536

TEAD ligand 2	Ligands for Target Protein for PROTAC YAP	Cancer
TEAD ligand 2 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534). PROTAC TEAD1/IAP degrader-1 is a potent **TEAD1/IAP PROTAC** degrader with anti-cancer activity .

HY-181595

TEAD ligand 5	Ligands for Target Protein for PROTAC YAP	Cancer
TEAD ligand 5 (Compound S19) is a *TEAD* *PROTAC* ligand. TEAD ligand 5 can be conjugated with E3 ligase Ligand (HY-181531) and linker (HY-181608) to synthesize PROTAC TEAD/IAP degrader-1 (HY-181594) .

HY-181535

IAP ligand-Linker Conjugate 1	E3 Ligase Ligand-Linker Conjugates IAP	Others
IAP ligand-Linker Conjugate 1 is a ligand-linker conjugate targeting IAP, which can be used in the synthesis of PROTAC TEAD1/IAP degrader-1 (HY-181534) .

HY-181531

IAP ligand 7	Ligands for E3 Ligase IAP	Cancer
IAP ligand 7 is an E3 ligase ligand. IAP ligand 7 can be conjugated with TEAD ligand (HY-181595) and linker (HY-181608) to synthesize PROTAC TEAD/IAP degrader-1 (HY-181594) .

Cat. No.	Product Name		Classification

HY-181534

**PROTAC TEAD1/IAP degrader-1**		PROTAC Synthesis
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective *TEAD1* and cIAP1 *PROTAC* degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the *TEAD*-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

HY-181536

TEAD ligand 2		PROTAC Synthesis
TEAD ligand 2 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534). PROTAC TEAD1/IAP degrader-1 is a potent **TEAD1/IAP PROTAC** degrader with anti-cancer activity .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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