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PTCs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (1) Apoptosis (5) Autophagy (5) Bacterial (2) Biochemical Assay Reagents (2) BMI1 (5) Casein Kinase (1) CFTR (5) Cytochrome P450 (1) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (2) Endogenous Metabolite (1) Environmental Pollutants (1) Eukaryotic Initiation Factor (eIF) (1) Ferroptosis (2) Flavivirus (1) Glucose-6-Phosphate Isomerase (GPI) (1) HCV (1) Huntingtin (2) Interleukin Related (1) Isotope-Labeled Compounds (1) JNK (1) Lipoxygenase (1) Mitochondrial Metabolism (1) mTOR (1) p38 MAPK (1) PI3K (1) Raf (1) Reference Standards (2) RET (1) Ribosomal S6 Kinase (RSK) (1) Src (1) VEGFR (1) Virus Protease (1) α-synuclein (1)
By Research Areas:	Cancer (16) Infection (5) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (5)

By Targets:

Akt (1)

Antibiotic (1)

Apoptosis (5)

Autophagy (5)

Bacterial (2)

Biochemical Assay Reagents (2)

BMI1 (5)

Casein Kinase (1)

CFTR (5)

Cytochrome P450 (1)

Dihydroorotate Dehydrogenase (1)

DNA/RNA Synthesis (2)

Endogenous Metabolite (1)

Environmental Pollutants (1)

Eukaryotic Initiation Factor (eIF) (1)

Ferroptosis (2)

Flavivirus (1)

Glucose-6-Phosphate Isomerase (GPI) (1)

HCV (1)

Huntingtin (2)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

JNK (1)

Lipoxygenase (1)

Mitochondrial Metabolism (1)

mTOR (1)

p38 MAPK (1)

PI3K (1)

Raf (1)

Reference Standards (2)

RET (1)

Ribosomal S6 Kinase (RSK) (1)

Src (1)

VEGFR (1)

Virus Protease (1)

α-synuclein (1)

By Research Areas:

Cancer (16)

Infection (5)

Inflammation/Immunology (3)

Metabolic Disease (3)

Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150090

SRI-41315 1 Publications Verification	CFTR	Inflammation/Immunology
SRI-41315 induces a prolonged pause at stop codons and suppresses *PTCs* (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity .

HY-15888

PTC-209 Maximum Cited Publications 16 Publications Verification	BMI1 Autophagy	Cancer
PTC-209 is a specific BMI-1 inhibitor with an IC₅₀ of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment .

HY-124593

PTC299 5 Publications Verification Emvododstat	VEGFR Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Cancer
PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies .

HY-14832

Ataluren 5+ Cited Publications PTC124	CFTR Autophagy	Metabolic Disease Cancer
Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

HY-112041

Unesbulin 3 Publications Verification PTC596	BMI1 Apoptosis	Cancer
Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity .

HY-16772

EPI-743 α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075	Mitochondrial Metabolism Ferroptosis	Neurological Disease
EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione .

HY-15898

Y-320 5 Publications Verification	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC₅₀ values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .

HY-103696

PTC-028 2 Publications Verification	BMI1 Apoptosis	Cancer
PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis .

HY-156650

Votoplam PTC518	Huntingtin	Neurological Disease
Votoplam (PTC518) (Example 37) is an HTT gene regulator with an IC₅₀ ≤ 0.1 μM. Votoplam can be used in the research of Huntington's disease .

HY-172815

IDB-001	JNK Eukaryotic Initiation Factor (eIF) p38 MAPK	Cancer
IDB-001 is a human ribosomal peptidyl transferase center (PTC) inhibitor that induces conformational changes and blocks translational elongation in specific sequence contexts through complementary interactions with Asp/Glu residues in nascent polypeptides. IDB-001 preferentially stalls ribosomes at positions containing acidic peptide motifs, thereby inhibiting cancer cell proliferation, and activates the integrated stress response via eIF2α phosphorylation at high concentrations. In addition, IDB-001 mildly triggers ribotoxic stress responses through phosphorylation of JNK and p38. IDB-001 has been applied to mechanistic studies of triple-negative breast cancer .

HY-Y0286

Ammonium carbonate, 99% Hartshorn salt, 99%	Environmental Pollutants Biochemical Assay Reagents	Others
Ammonium carbonate (Ammonium carbonate), 99% is a solid amino compound that functions as a buffer, pH regulator, pore-forming agent, and electrocatalytic oxidation substrate. Ammonium carbonate, 99% is a GRAS-grade direct food additive with no restricted daily intake specified by FAO/WHO, and it shows no acute skin toxicity, clinical signs of toxicity, or effects on body weight in rats. Ammonium carbonate, 99% undergoes electrocatalytic oxidation in alkaline solutions with a Pt/C catalyst (carbonate adsorption interferes with activity). Ammonium carbonate, 99% can serve as a fuel for low-temperature polymer fuel cells and anion exchange membrane fuel cells (with performance superior to pure ammonia), and can also form pores in the carrier-free Pt cathode catalyst layer after low-temperature decomposition, thereby enhancing catalyst activity under low-humidity conditions and the performance of proton exchange membrane fuel cells .

HY-150089

SRI-37240	CFTR	Inflammation/Immunology
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .

HY-148772

PTC258	DNA/RNA Synthesis	Neurological Disease
PTC258 is a specific and orally active splicing modulator of Elongator complex protein 1 gene (ELP1). PTC258 increases the expression of ELP1 in vitro and in vivo. PTC258 is well tolerated in mouse model .

HY-132845

Utreloxastat PTC857	α-synuclein Cytochrome P450 Ferroptosis Lipoxygenase	Neurological Disease
Utreloxastat (PTC857) is an orally active and blood-brain barrier-permeable 15-lipooxygenase inhibitor. Utreloxastat is a weak inhibitor of CYP1A2 and 2B6 with an IC₅₀ of >5.3 μM. Utreloxastat reduces oxidative stress and inhibits the consumption of reduced glutathione and ferroptosis. Utreloxastat can be used in the study of neurodegenerative diseases characterized by high levels of oxidative stress and mitochondrial pathology, such as amyotrophic lateral sclerosisc .

HY-N6841

Rhodiolin 1 Publications Verification	Glucose-6-Phosphate Isomerase (GPI) Casein Kinase Virus Protease Flavivirus PI3K Akt mTOR Apoptosis	Infection Cancer
Rhodiolin, a flavonoid, is an orally active glucose 6-phosphate isomerase (GPI) inhibitor. Rhodiolin inhibits papillary thyroid cancer (PTC) by targeting glycolysis enzyme glucose 6-phosphate isomerase GPI and suppressing PI3K/AKT/mTOR phosphorylation and induce apoptosis. Rhodiolin as a NS2B-NS3 protease inhibitor can disrupt dengue viral replication. Rhodiolin is also a potential candidate for developing anticancer strategies inhibiting CK1ε kinase. Rhodiolin can be used for the study of anti-tumor and anti-viral .

HY-15888A

PTC-209 hydrobromide Maximum Cited Publications 16 Publications Verification	BMI1 Autophagy	Cancer
PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC₅₀ of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment .

HY-14832R

Ataluren (Standard) 1 Publications Verification PTC124 (Standard)	Reference Standards CFTR Autophagy	Metabolic Disease Cancer
Ataluren (Standard) is the analytical standard of Ataluren. This product is intended for research and analytical applications. Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

HY-18507

AD57	RET Raf Ribosomal S6 Kinase (RSK) Src	Cancer
AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity .

HY-118593

A2315A Madumycin II; Antibiotic A 2315A	Antibiotic	Infection
A2315A (Madumycin II) is an alanine-containing streptogramin A antibiotic. A2315A is a potent peptidyl transferase center (PTC) inhibitor. A2315A inhibits the ribosome prior to the first cycle of peptide bond formation .

HY-156650A

Votoplam hydrochloride PTC518 hydrochloride	Huntingtin	Neurological Disease
Votoplam (PTC518) hydrochloride is an HTT gene regulator with an IC₅₀ ≤ 0.1 μM. Votoplam hydrochloride can be used in the research of Huntington's disease .

HY-137911

Sparsomycin	Bacterial	Infection Cancer
Sparsomycin is a metabolite of the bacterium Streptomyces sparsogenes. Sparsomycin inhibits protein synthesis in both eukaryotic cells and bacteria. Sparsomycin inhibits the translation extension of ribosome PTC .

HY-12732

PTC 725	HCV	Infection
PTC 725 is a potent, selective and orally active Hepatitis C Virus NS4B Protein inhibitor. PTC 725 inhibits HCV 1b (Con1) replicons .

HY-14832S1

Ataluren-13C6 PTC124-¹³C₆	Isotope-Labeled Compounds Autophagy CFTR	Metabolic Disease Cancer
Ataluren- ¹³C₆ (PTC124- ¹³C₆) is ¹³C labeled Ataluren. Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

HY-103696R

PTC-028 (Standard)	BMI1 Reference Standards Apoptosis	Cancer
PTC-028 (Standard) is the analytical standard of PTC-028 (HY-103696). This product is intended for research and analytical applications. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis .

HY-125059

PTC-510 free base	Endogenous Metabolite	Cancer
PTC-510 Free base is a compound that selectively inhibits hypoxia-induced VEGF expression in tumor cells. PTC-510 Free base demonstrates potent activity in reducing endogenous VEGF production under hypoxic conditions. PTC-510 Free base has been shown to control tumor growth effectively while minimizing toxicity. PTC-510 Free base represents a novel therapeutic strategy to address the limitations of current anti-VEGF therapies.

HY-179405

Antibacterial agent 301	Bacterial	Infection
Antibacterial agent 301 (compound 14c) is a pyridine-amide pleuromutilin derivative with broad-spectrum antibacterial and pronounced antimycoplasmal activity. Antibacterial agent 301 inhibits peptidyl transferase center (PTC), breaks down biofilms, and disrupts cell membranes in multidrug-resistant (MDR) bacteria. Antibacterial agent 301 exhibits activity in a systemic methicillin-resistant Staphylococcus aureus (MRSA) infection mouse model. Antibacterial agent 301 can be used for MDR bacterial infection research .

HY-P11766

GALA-chol GALA-cholesterol	Biochemical Assay Reagents	Cancer
GALA-chol is a cholesterol-conjugated pH-responsive fusion peptide that can serve as a delivery adjuvant. GALA-chol enhances the endocytosis of siRNA *RET/PTC1*-SQ nanoparticles, inhibits cell viability, and undergoes pH-responsive charge conversion in the acidic lysosomal environment, thereby promoting lysosomal escape of small extracellular vesicle (sEV) cargo. GALA-chol anchors to the sEV membrane and maintains the structural integrity and intrinsic homing activity of sEVs. GALA-chol can be used in studies related to adjuvant delivery .

Cat. No.	Product Name	Type

HY-Y0286

Ammonium carbonate, 99% Hartshorn salt, 99%	Biochemical Assay Reagents
Ammonium carbonate (Ammonium carbonate), 99% is a solid amino compound that functions as a buffer, pH regulator, pore-forming agent, and electrocatalytic oxidation substrate. Ammonium carbonate, 99% is a GRAS-grade direct food additive with no restricted daily intake specified by FAO/WHO, and it shows no acute skin toxicity, clinical signs of toxicity, or effects on body weight in rats. Ammonium carbonate, 99% undergoes electrocatalytic oxidation in alkaline solutions with a Pt/C catalyst (carbonate adsorption interferes with activity). Ammonium carbonate, 99% can serve as a fuel for low-temperature polymer fuel cells and anion exchange membrane fuel cells (with performance superior to pure ammonia), and can also form pores in the carrier-free Pt cathode catalyst layer after low-temperature decomposition, thereby enhancing catalyst activity under low-humidity conditions and the performance of proton exchange membrane fuel cells .

Ammonium carbonate, 99%

Hartshorn salt, 99%

Biochemical Assay Reagents

Ammonium carbonate (Ammonium carbonate), 99% is a solid amino compound that functions as a buffer, pH regulator, pore-forming agent, and electrocatalytic oxidation substrate. Ammonium carbonate, 99% is a GRAS-grade direct food additive with no restricted daily intake specified by FAO/WHO, and it shows no acute skin toxicity, clinical signs of toxicity, or effects on body weight in rats. Ammonium carbonate, 99% undergoes electrocatalytic oxidation in alkaline solutions with a Pt/C catalyst (carbonate adsorption interferes with activity). Ammonium carbonate, 99% can serve as a fuel for low-temperature polymer fuel cells and anion exchange membrane fuel cells (with performance superior to pure ammonia), and can also form pores in the carrier-free Pt cathode catalyst layer after low-temperature decomposition, thereby enhancing catalyst activity under low-humidity conditions and the performance of proton exchange membrane fuel cells .

Cat. No.	Product Name	Target	Research Area

HY-P11766

GALA-chol GALA-cholesterol	Biochemical Assay Reagents	Cancer
GALA-chol is a cholesterol-conjugated pH-responsive fusion peptide that can serve as a delivery adjuvant. GALA-chol enhances the endocytosis of siRNA *RET/PTC1*-SQ nanoparticles, inhibits cell viability, and undergoes pH-responsive charge conversion in the acidic lysosomal environment, thereby promoting lysosomal escape of small extracellular vesicle (sEV) cargo. GALA-chol anchors to the sEV membrane and maintains the structural integrity and intrinsic homing activity of sEVs. GALA-chol can be used in studies related to adjuvant delivery .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6841

Rhodiolin 1 Publications Verification	Flavonols Flavonoids Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Glucose-6-Phosphate Isomerase (GPI) Casein Kinase Virus Protease Flavivirus PI3K Akt mTOR Apoptosis
Rhodiolin, a flavonoid, is an orally active glucose 6-phosphate isomerase (GPI) inhibitor. Rhodiolin inhibits papillary thyroid cancer (PTC) by targeting glycolysis enzyme glucose 6-phosphate isomerase GPI and suppressing PI3K/AKT/mTOR phosphorylation and induce apoptosis. Rhodiolin as a NS2B-NS3 protease inhibitor can disrupt dengue viral replication. Rhodiolin is also a potential candidate for developing anticancer strategies inhibiting CK1ε kinase. Rhodiolin can be used for the study of anti-tumor and anti-viral .

HY-118593

A2315A Madumycin II; Antibiotic A 2315A	Structural Classification Natural Products Microorganisms Source Classification	Antibiotic
A2315A (Madumycin II) is an alanine-containing streptogramin A antibiotic. A2315A is a potent peptidyl transferase center (PTC) inhibitor. A2315A inhibits the ribosome prior to the first cycle of peptide bond formation .

Cat. No.	Product Name	Chemical Structure

HY-14832S1

Ataluren-13C6
Ataluren- ¹³C₆ (PTC124- ¹³C₆) is ¹³C labeled Ataluren. Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

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