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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
Pol α
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "Pol α" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-W015490
CAS No.: 130-15-4
Research Areas:
1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
3
3 Cited Publications
Cat. No.: HY-P77587
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
1
1 Cited Publications
Cat. No.: HY-N2566
CAS No.: 53155-25-2
Target:
Cat. No.: HY-W015490S
CAS No.: 26473-08-5
Cat. No.: HY-100513
CAS No.: 34279-44-2
Category:
Target:
Cat. No.: HY-W015490R
CAS No.: 130-15-4
Research Areas:
1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
Cat. No.: HY-179413
CAS No.: 3050552-13-8
Target:
Research Areas:
Polθ-IN-9 is an orally active Polθ polymerase inhibitor (IC50 = 9.6 nM, Kd = 47.5 nM). Polθ-IN-9 shows remarkable selectivity with no inhibitory activity against other human DNA polymerases, including Pol α, Pol ε, Pol γ, Pol λ, and Pol μ. Polθ-IN-9 exhibits strong antiproliferative activity in DLD1 BRCA2 KO cells (IC50 = 2.9 μM), and high sensitivity to MDA-MB-436 cells (IC50 = 4.9 μM). Polθ-IN-9 increases DNA damage accumulation, induces γH2AX levels, and inhibits tumor growth in combination with Olaparib (HY-10162), in the MDA-MB-436 xenograft model. Polθ-IN-9 can be used for the research of homologous recombination (HR)-deficient cancers such as breast cancer .
CDK2-IN-51 is a pyrazolopyridine derivative, a CDK2 inhibitor with an IC50 of 23.47 nM. CDK2-IN-51 does not have a pro-apoptotic effect and had no significant effect on CDK2 protein expression. CDK2-IN-51 reduces expression of DNA replication factors (Polα, MCM7, ORC2, and ORC4) and pre-G1 cell cycle arrest. CDK2-IN-51 can be used for the research of colorectal cancer .
Cat. No.: HY-P71702
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Cat. No.: HY-P7708A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Cat. No.: HY-P7707
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Cat. No.: HY-P77586
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Cat. No.: HY-P7708
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Cat. No.: HY-P700614
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related Polypeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Species:
Source:
Cat. No.: HY-P71662
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD8A; Leu2 T-Lymphocyte Antigen; Prev. CD8; T-Cell Antigen Leu2; T-Cell Surface Glycoprotein CD8 Alpha Chain; T Cell Co-Receptor; T-Lymphocyte Differentiation Antigen T8/Leu-2; T8 T-Cell Antigen; CD8alpha; CD8a Antigen; P32; IMD116; CD8 Antigen, Alpha Pol
Cat. No.: HY-P74267
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD8A; Leu2 T-Lymphocyte Antigen; Prev. CD8; T-Cell Antigen Leu2; T-Cell Surface Glycoprotein CD8 Alpha Chain; T Cell Co-Receptor; T-Lymphocyte Differentiation Antigen T8/Leu-2; T8 T-Cell Antigen; CD8alpha; CD8a Antigen; P32; IMD116; CD8 Antigen, Alpha Pol
Cat. No.: HY-P74268
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD8A; Leu2 T-Lymphocyte Antigen; Prev. CD8; T-Cell Antigen Leu2; T-Cell Surface Glycoprotein CD8 Alpha Chain; T Cell Co-Receptor; T-Lymphocyte Differentiation Antigen T8/Leu-2; T8 T-Cell Antigen; CD8alpha; CD8a Antigen; P32; IMD116; CD8 Antigen, Alpha Pol
Cat. No.: HY-P74269
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD8A; Leu2 T-Lymphocyte Antigen; Prev. CD8; T-Cell Antigen Leu2; T-Cell Surface Glycoprotein CD8 Alpha Chain; T Cell Co-Receptor; T-Lymphocyte Differentiation Antigen T8/Leu-2; T8 T-Cell Antigen; CD8alpha; CD8a Antigen; P32; IMD116; CD8 Antigen, Alpha Pol
Cat. No.: HY-P75380
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD8A; Leu2 T-Lymphocyte Antigen; Prev. CD8; T-Cell Antigen Leu2; T-Cell Surface Glycoprotein CD8 Alpha Chain; T Cell Co-Receptor; T-Lymphocyte Differentiation Antigen T8/Leu-2; T8 T-Cell Antigen; CD8alpha; CD8a Antigen; P32; IMD116; CD8 Antigen, Alpha Pol
Cat. No.: HY-P75381
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD8A; Leu2 T-Lymphocyte Antigen; Prev. CD8; T-Cell Antigen Leu2; T-Cell Surface Glycoprotein CD8 Alpha Chain; T Cell Co-Receptor; T-Lymphocyte Differentiation Antigen T8/Leu-2; T8 T-Cell Antigen; CD8alpha; CD8a Antigen; P32; IMD116; CD8 Antigen, Alpha Pol
Species:
Source:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
