34279-44-2
Chemical Structure
(±)-Dehydroaltenusin
- CAS No.: 34279-44-2
- Formula:C15H12O6
- Molecular Weight:288.25
IUPAC Name: 3,7-dihydroxy-9-methoxy-4a-methyl-6H-benzo[c]chromene-2,6(4aH)-dione
InChIKey: YWYZLBQRCUAQAV-UHFFFAOYSA-N
SMILES: O=C(C(O)=C1)C=C(C2=CC(OC)=CC(O)=C23)C1(C)OC3=O
Biological Activity: (±)-Dehydroaltenusin, an antibiotic, is a selective eukaryotic DNA polymerase α (pol α) inhibitor with an IC50 of 0.68 μM. (±)-Dehydroaltenusin can be isolated from fungus Alternaria tenuis. (±)-Dehydroaltenusin competitively inhibits the DNA template primer (Ki: 0.23 μM) and non-competitively suppresses the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki: 0.18 μM). (±)-Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis. (±)-Dehydroaltenusin can be used for cancers like human adenocarcinoma research[1].
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(±)-Dehydroaltenusin | (±)-Dehydroaltenusin, an antibiotic, is a selective eukaryotic DNA polymerase α (pol α) inhibitor with an IC50 of 0.68 μM. (±)-Dehydroaltenusin can be isolated from fungus Alternaria tenuis. (±)-Dehydroaltenusin competitively inhibits the DNA template primer (Ki: 0.23 μM) and non-competitively suppresses the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki: 0.18 μM). (±)-Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis. (±)-Dehydroaltenusin can be used for cancers like human adenocarcinoma research. | |||||||||||||||||||||
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Keywords
