1443-10-3
1443-10-3
Chemical Structure
CDK2-IN-51
- CAS No.: 1443-10-3
- Formula:C18H16N4
- Molecular Weight:288.35
InChIKey: CIVYGVCDHVJCCJ-UHFFFAOYSA-N
SMILES: CC1=NC2=NN3C(C)=CC(C)=NC3=C2C(C4=CC=CC=C4)=C1
Biological Activity: CDK2-IN-51 is a pyrazolopyridine derivative, a CDK2 inhibitor with an IC50 of 23.47 nM. CDK2-IN-51 does not have a pro-apoptotic effect and had no significant effect on CDK2 protein expression. CDK2-IN-51 reduces expression of DNA replication factors (Polα, MCM7, ORC2, and ORC4) and pre-G1 cell cycle arrest. CDK2-IN-51 can be used for the research of colorectal cancer[1].
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CDK2-IN-51 | CDK2-IN-51 is a pyrazolopyridine derivative, a CDK2 inhibitor with an IC50 of 23.47 nM. CDK2-IN-51 does not have a pro-apoptotic effect and had no significant effect on CDK2 protein expression. CDK2-IN-51 reduces expression of DNA replication factors (Polα, MCM7, ORC2, and ORC4) and pre-G1 cell cycle arrest. CDK2-IN-51 can be used for the research of colorectal cancer. | |||||||||||||||||||||
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